Liane S. Canas

Daniele Falcetta, Liane S. Canas, Lorenzo Suppa et al.

We present CaravelMetrics, a computational framework for automated cerebrovascular analysis that models vessel morphology through skeletonization-derived graph representations. The framework integrates atlas-based regional parcellation, centerline extraction, and graph construction to compute fifteen morphometric, topological, fractal, and geometric features. The features can be estimated globally from the complete vascular network or regionally within arterial territories, enabling multiscale characterization of cerebrovascular organization. Applied to 570 3D TOF-MRA scans from the IXI dataset (ages 20-86), CaravelMetrics yields reproducible vessel graphs capturing age- and sex-related variations and education-associated increases in vascular complexity, consistent with findings reported in the literature. The framework provides a scalable and fully automated approach for quantitative cerebrovascular feature extraction, supporting normative modeling and population-level studies of vascular health and aging.

Benjamin Murray, Eric Kerfoot, Mark S. Graham et al.

The Covid Symptom Study, a smartphone-based surveillance study on COVID-19 symptoms in the population, is an exemplar of big data citizen science. Over 4.7 million participants and 189 million unique assessments have been logged since its introduction in March 2020. The success of the Covid Symptom Study creates technical challenges around effective data curation for two reasons. Firstly, the scale of the dataset means that it can no longer be easily processed using standard software on commodity hardware. Secondly, the size of the research group means that replicability and consistency of key analytics used across multiple publications becomes an issue. We present ExeTera, an open source data curation software designed to address scalability challenges and to enable reproducible research across an international research group for datasets such as the Covid Symptom Study dataset.