Hang Wu

CV
h-index28
22papers
441citations
Novelty55%
AI Score59

22 Papers

AIFeb 5, 2025Code
BFS-Prover: Scalable Best-First Tree Search for LLM-based Automatic Theorem Proving

Ran Xin, Chenguang Xi, Jie Yang et al.

Recent advancements in large language models (LLMs) have spurred growing interest in automatic theorem proving using Lean4, where effective tree search methods are crucial for navigating the underlying large proof search spaces. While the existing approaches primarily rely on value functions and/or Monte Carlo Tree Search (MCTS), the potential of simpler methods like Best-First Tree Search (BFS) remains underexplored. In this paper, we investigate whether BFS can achieve competitive performance in large-scale theorem proving tasks. We present BFS-Prover, a scalable expert iteration framework, featuring three key innovations. First, we implement strategic data filtering at each expert iteration round, excluding problems solvable via beam search node expansion to focus on harder cases. Second, we improve the sample efficiency of BFS through Direct Preference Optimization (DPO) applied to state-tactic pairs automatically annotated with compiler error feedback, refining the LLM's policy to prioritize productive expansions. Third, we employ length normalization in BFS to encourage exploration of deeper proof paths. BFS-Prover achieves a state-of-the-art score of $72.95\%$ on the MiniF2F test set and therefore challenges the perceived necessity of complex tree search methods, demonstrating that BFS can achieve competitive performance when properly scaled. To facilitate further research and development in this area, we have open-sourced our model at https://huggingface.co/ByteDance-Seed/BFS-Prover-V1-7B.

CVJan 30
CamReasoner: Reinforcing Camera Movement Understanding via Structured Spatial Reasoning

Hang Wu, Yujun Cai, Zehao Li et al.

Understanding camera dynamics is a fundamental pillar of video spatial intelligence. However, existing multimodal models predominantly treat this task as a black-box classification, often confusing physically distinct motions by relying on superficial visual patterns rather than geometric cues. We present CamReasoner, a framework that reformulates camera movement understanding as a structured inference process to bridge the gap between perception and cinematic logic. Our approach centers on the Observation-Thinking-Answer (O-T-A) paradigm, which compels the model to decode spatio-temporal cues such as trajectories and view frustums within an explicit reasoning block. To instill this capability, we construct a Large-scale Inference Trajectory Suite comprising 18k SFT reasoning chains and 38k RL feedback samples. Notably, we are the first to employ RL for logical alignment in this domain, ensuring motion inferences are grounded in physical geometry rather than contextual guesswork. By applying Reinforcement Learning to the Observation-Think-Answer (O-T-A) reasoning paradigm, CamReasoner effectively suppresses hallucinations and achieves state-of-the-art performance across multiple benchmarks.

CVJul 11, 2024
MapLocNet: Coarse-to-Fine Feature Registration for Visual Re-Localization in Navigation Maps

Hang Wu, Zhenghao Zhang, Siyuan Lin et al.

Robust localization is the cornerstone of autonomous driving, especially in challenging urban environments where GPS signals suffer from multipath errors. Traditional localization approaches rely on high-definition (HD) maps, which consist of precisely annotated landmarks. However, building HD map is expensive and challenging to scale up. Given these limitations, leveraging navigation maps has emerged as a promising low-cost alternative for localization. Current approaches based on navigation maps can achieve highly accurate localization, but their complex matching strategies lead to unacceptable inference latency that fails to meet the real-time demands. To address these limitations, we propose a novel transformer-based neural re-localization method. Inspired by image registration, our approach performs a coarse-to-fine neural feature registration between navigation map and visual bird's-eye view features. Our method significantly outperforms the current state-of-the-art OrienterNet on both the nuScenes and Argoverse datasets, which is nearly 10%/20% localization accuracy and 30/16 FPS improvement on single-view and surround-view input settings, separately. We highlight that our research presents an HD-map-free localization method for autonomous driving, offering cost-effective, reliable, and scalable performance in challenging driving environments.

CVJul 11, 2024
BLOS-BEV: Navigation Map Enhanced Lane Segmentation Network, Beyond Line of Sight

Hang Wu, Zhenghao Zhang, Siyuan Lin et al.

Bird's-eye-view (BEV) representation is crucial for the perception function in autonomous driving tasks. It is difficult to balance the accuracy, efficiency and range of BEV representation. The existing works are restricted to a limited perception range within 50 meters. Extending the BEV representation range can greatly benefit downstream tasks such as topology reasoning, scene understanding, and planning by offering more comprehensive information and reaction time. The Standard-Definition (SD) navigation maps can provide a lightweight representation of road structure topology, characterized by ease of acquisition and low maintenance costs. An intuitive idea is to combine the close-range visual information from onboard cameras with the beyond line-of-sight (BLOS) environmental priors from SD maps to realize expanded perceptual capabilities. In this paper, we propose BLOS-BEV, a novel BEV segmentation model that incorporates SD maps for accurate beyond line-of-sight perception, up to 200m. Our approach is applicable to common BEV architectures and can achieve excellent results by incorporating information derived from SD maps. We explore various feature fusion schemes to effectively integrate the visual BEV representations and semantic features from the SD map, aiming to leverage the complementary information from both sources optimally. Extensive experiments demonstrate that our approach achieves state-of-the-art performance in BEV segmentation on nuScenes and Argoverse benchmark. Through multi-modal inputs, BEV segmentation is significantly enhanced at close ranges below 50m, while also demonstrating superior performance in long-range scenarios, surpassing other methods by over 20% mIoU at distances ranging from 50-200m.

CVNov 14, 2025
PAS: A Training-Free Stabilizer for Temporal Encoding in Video LLMs

Bowen Sun, Yujun Cai, Ming-Hsuan Yang et al.

Video LLMs suffer from temporal inconsistency: small shifts in frame timing can flip attention and suppress relevant frames. We trace this instability to the common extension of Rotary Position Embeddings to video through multimodal RoPE. The induced inverse Fourier time kernel exhibits frame-scale ripples that multiply adjacent frames by different factors, which perturbs attention that should otherwise be governed by the raw query key inner product. We present Phase Aggregated Smoothing (PAS), a simple, training-free mechanism that applies small opposed phase offsets across heads and then aggregates their outputs. PAS preserves the per-head spectrum magnitude, while the aggregation effectively smooths the temporal kernel and reduces phase sensitivity without changing the positional encoding structure. Our analysis shows that the RoPE rotated logit can be approximated as a content dot product scaled by a time kernel; smoothing this kernel yields Lipschitz stability of attention to small temporal shifts; multi phase averaging attenuates high frequency ripples while preserving per-head spectra under Nyquist-valid sampling. Experiments on multiple video understanding benchmarks under matched token budgets show consistent improvements with negligible computational overhead. PAS provides a plug and play upgrade for robust temporal encoding in Video LLMs.

CLMar 4, 2024Code
Balancing Enhancement, Harmlessness, and General Capabilities: Enhancing Conversational LLMs with Direct RLHF

Chen Zheng, Ke Sun, Hang Wu et al.

In recent advancements in Conversational Large Language Models (LLMs), a concerning trend has emerged, showing that many new base LLMs experience a knowledge reduction in their foundational capabilities following Supervised Fine-Tuning (SFT). This process often leads to issues such as forgetting or a decrease in the base model's abilities. Moreover, fine-tuned models struggle to align with user preferences, inadvertently increasing the generation of toxic outputs when specifically prompted. To overcome these challenges, we adopted an innovative approach by completely bypassing SFT and directly implementing Harmless Reinforcement Learning from Human Feedback (RLHF). Our method not only preserves the base model's general capabilities but also significantly enhances its conversational abilities, while notably reducing the generation of toxic outputs. Our approach holds significant implications for fields that demand a nuanced understanding and generation of responses, such as customer service. We applied this methodology to Mistral, the most popular base model, thereby creating Mistral-Plus. Our validation across 11 general tasks demonstrates that Mistral-Plus outperforms similarly sized open-source base models and their corresponding instruct versions. Importantly, the conversational abilities of Mistral-Plus were significantly improved, indicating a substantial advancement over traditional SFT models in both safety and user preference alignment.

CVDec 1, 2025
M4-BLIP: Advancing Multi-Modal Media Manipulation Detection through Face-Enhanced Local Analysis

Hang Wu, Ke Sun, Jiayi Ji et al.

In the contemporary digital landscape, multi-modal media manipulation has emerged as a significant societal threat, impacting the reliability and integrity of information dissemination. Current detection methodologies in this domain often overlook the crucial aspect of localized information, despite the fact that manipulations frequently occur in specific areas, particularly in facial regions. In response to this critical observation, we propose the M4-BLIP framework. This innovative framework utilizes the BLIP-2 model, renowned for its ability to extract local features, as the cornerstone for feature extraction. Complementing this, we incorporate local facial information as prior knowledge. A specially designed alignment and fusion module within M4-BLIP meticulously integrates these local and global features, creating a harmonious blend that enhances detection accuracy. Furthermore, our approach seamlessly integrates with Large Language Models (LLM), significantly improving the interpretability of the detection outcomes. Extensive quantitative and visualization experiments validate the effectiveness of our framework against the state-of-the-art competitors.

CLJun 4, 2025Code
MedAgentGym: A Scalable Agentic Training Environment for Code-Centric Reasoning in Biomedical Data Science

Ran Xu, Yuchen Zhuang, Yishan Zhong et al. · gatech

We introduce MedAgentGym, a scalable and interactive training environment designed to enhance coding-based biomedical reasoning capabilities in large language model (LLM) agents. MedAgentGym comprises 72,413 task instances across 129 categories derived from 12 authentic real-world biomedical scenarios. Tasks are encapsulated within executable sandbox environments, each featuring detailed task specifications, interactive feedback mechanisms, verifiable ground truth annotations, and scalable training trajectory generation. Extensive benchmarking of 29 LLMs reveals substantial performance disparities in biomedical data science between commercial and open-source LLMs. Leveraging efficient multi-threaded and multi-turn trajectory sampling in MedAgentGym, Med-Copilot achieves performance gains of +43.02% and +45.28% from offline and online reinforcement learning, respectively, demonstrating MedAgentGym as an effective training ground while establishing itself as a cost-effective, privacy-preserving alternative competitive with proprietary LLMs (gpt-4o). By offering a unified execution environment with a comprehensive benchmark and accessible, extensible training resources, MedAgentGym delivers an integrated platform to develop LLM-based coding assistants for advanced biomedical data science.

CLJan 13, 2024
EHRAgent: Code Empowers Large Language Models for Few-shot Complex Tabular Reasoning on Electronic Health Records

Wenqi Shi, Ran Xu, Yuchen Zhuang et al. · gatech

Large language models (LLMs) have demonstrated exceptional capabilities in planning and tool utilization as autonomous agents, but few have been developed for medical problem-solving. We propose EHRAgent, an LLM agent empowered with a code interface, to autonomously generate and execute code for multi-tabular reasoning within electronic health records (EHRs). First, we formulate an EHR question-answering task into a tool-use planning process, efficiently decomposing a complicated task into a sequence of manageable actions. By integrating interactive coding and execution feedback, EHRAgent learns from error messages and improves the originally generated code through iterations. Furthermore, we enhance the LLM agent by incorporating long-term memory, which allows EHRAgent to effectively select and build upon the most relevant successful cases from past experiences. Experiments on three real-world multi-tabular EHR datasets show that EHRAgent outperforms the strongest baseline by up to 29.6% in success rate. EHRAgent leverages the emerging few-shot learning capabilities of LLMs, enabling autonomous code generation and execution to tackle complex clinical tasks with minimal demonstrations.

91.4CVMay 8
Semantic-Aware Adaptive Visual Memory for Streaming Video Understanding

Hang Wu, Sherin Mary Mathews, Yujun Cai et al.

Online streaming video understanding requires models to process continuous visual inputs and respond to user queries in real time, where the unbounded stream and unpredictable query timing turn memory management into a central challenge. Existing methods typically compress visual tokens via visual similarity heuristics, or augment compression with KV-cache-level retrieval. However, compression decisions rarely incorporate semantic signals, and retrieval is often added after compression is finalized, making the two stages hard to coordinate. We present SAVEMem, a training-free dual-stage framework that brings semantic awareness into memory generation and lets the retrieval scope adapt per query. In Stage~1, SAVEMem builds a three-tier streaming memory online under a constant memory budget. A fixed pseudo-question bank provides a lightweight semantic prior, so that long-term retention is shaped by semantic salience rather than visual similarity alone. In Stage~2, SAVEMem performs query-aware retrieval over this memory. An anchor-conditioned recency gate adapts the retrieval scope from short-term to mid- and long-term memory based on whether the query targets the present or the distant past. Within this scope, late interaction between query and memory tokens selects candidate frames for answering. Applied to Qwen2.5-VL without training, SAVEMem improves the OVO-Bench overall score from 52.27 to 62.69 and yields consistent gains on StreamingBench and ODV-Bench, while reducing peak GPU memory by 48\% at 128 frames over the backbone.

CLMay 5, 2024
MedAdapter: Efficient Test-Time Adaptation of Large Language Models towards Medical Reasoning

Wenqi Shi, Ran Xu, Yuchen Zhuang et al. · gatech

Despite their improved capabilities in generation and reasoning, adapting large language models (LLMs) to the biomedical domain remains challenging due to their immense size and corporate privacy. In this work, we propose MedAdapter, a unified post-hoc adapter for test-time adaptation of LLMs towards biomedical applications. Instead of fine-tuning the entire LLM, MedAdapter effectively adapts the original model by fine-tuning only a small BERT-sized adapter to rank candidate solutions generated by LLMs. Experiments demonstrate that MedAdapter effectively adapts both white-box and black-box LLMs in biomedical reasoning, achieving average performance improvements of 25.48% and 11.31%, respectively, without requiring extensive computational resources or sharing data with third parties. MedAdapter also yields superior performance when combined with train-time adaptation, highlighting a flexible and complementary solution to existing adaptation methods. Faced with the challenges of balancing model performance, computational resources, and data privacy, MedAdapter provides an efficient, privacy-preserving, cost-effective, and transparent solution for adapting LLMs to the biomedical domain.

AIJun 12, 2025
DiMo-GUI: Advancing Test-time Scaling in GUI Grounding via Modality-Aware Visual Reasoning

Hang Wu, Hongkai Chen, Yujun Cai et al.

Grounding natural language queries in graphical user interfaces (GUIs) poses unique challenges due to the diversity of visual elements, spatial clutter, and the ambiguity of language. In this paper, we introduce DiMo-GUI, a training-free framework for GUI grounding that leverages two core strategies: dynamic visual grounding and modality-aware optimization. Instead of treating the GUI as a monolithic image, our method splits the input into textual elements and iconic elements, allowing the model to reason over each modality independently using general-purpose vision-language models. When predictions are ambiguous or incorrect, DiMo-GUI dynamically focuses attention by generating candidate focal regions centered on the model's initial predictions and incrementally zooms into subregions to refine the grounding result. This hierarchical refinement process helps disambiguate visually crowded layouts without the need for additional training or annotations. We evaluate our approach on standard GUI grounding benchmarks and demonstrate consistent improvements over baseline inference pipelines, highlighting the effectiveness of combining modality separation with region-focused reasoning.

CVOct 9, 2025
SpatialLadder: Progressive Training for Spatial Reasoning in Vision-Language Models

Hongxing Li, Dingming Li, Zixuan Wang et al.

Spatial reasoning remains a fundamental challenge for Vision-Language Models (VLMs), with current approaches struggling to achieve robust performance despite recent advances. We identify that this limitation stems from a critical gap: existing methods attempt to learn spatial reasoning directly without establishing the hierarchical foundations of perception and understanding. To address this challenge, we present a comprehensive methodology for building spatial intelligence progressively. We introduce SpatialLadder-26k, a multimodal dataset containing 26,610 samples spanning object localization, single image, multi-view, and video spatial reasoning tasks, constructed through a standardized pipeline that ensures systematic coverage across modalities. Building on this dataset, we design a three-stage progressive training framework that (1) establishes spatial perception through object localization, (2) develops spatial understanding through multi-dimensional spatial tasks, and (3) strengthens complex reasoning via reinforcement learning with verifiable rewards. This approach yields SpatialLadder, a 3B-parameter model that achieves state-of-the-art performance on spatial reasoning benchmarks, with 23.4% average improvement over the base model, surpassing GPT-4o by 20.8% and Gemini-2.0-Flash by 10.1%. Notably, SpatialLadder maintains strong generalization with 7.2% improvement on out-of-domain benchmarks, demonstrating that progressive training from perception to reasoning is essential for robust spatial intelligence.

CLJun 19, 2025
Structured Attention Matters to Multimodal LLMs in Document Understanding

Chang Liu, Hongkai Chen, Yujun Cai et al.

Document understanding remains a significant challenge for multimodal large language models (MLLMs). While previous research has primarily focused on locating evidence pages through precise multimodal queries, our work investigates a fundamental yet overlooked aspect: how input format influences document comprehension performance. Through systematic analysis, we discover that raw OCR text often impairs rather than improves MLLMs' performance, which is a counterintuitive finding we attribute to attention dispersion and structure loss. To further substantiate our hypothesis, we propose a novel structure-preserving approach that encodes document elements using the LaTex paradigm, maintaining the hierarchical organization and spatial relationships critical for comprehension. Our attention analysis reveals that structured text induces structured attention patterns on both textual and visual content, directing models to focus on semantically meaningful regions while reducing attention waste. This approach significantly enhances MLLMs' document question answering performance across diverse document types without requiring architectural modifications or additional training.

CVJun 16, 2025
STAGE: A Stream-Centric Generative World Model for Long-Horizon Driving-Scene Simulation

Jiamin Wang, Yichen Yao, Xiang Feng et al.

The generation of temporally consistent, high-fidelity driving videos over extended horizons presents a fundamental challenge in autonomous driving world modeling. Existing approaches often suffer from error accumulation and feature misalignment due to inadequate decoupling of spatio-temporal dynamics and limited cross-frame feature propagation mechanisms. To address these limitations, we present STAGE (Streaming Temporal Attention Generative Engine), a novel auto-regressive framework that pioneers hierarchical feature coordination and multi-phase optimization for sustainable video synthesis. To achieve high-quality long-horizon driving video generation, we introduce Hierarchical Temporal Feature Transfer (HTFT) and a novel multi-stage training strategy. HTFT enhances temporal consistency between video frames throughout the video generation process by modeling the temporal and denoising process separately and transferring denoising features between frames. The multi-stage training strategy is to divide the training into three stages, through model decoupling and auto-regressive inference process simulation, thereby accelerating model convergence and reducing error accumulation. Experiments on the Nuscenes dataset show that STAGE has significantly surpassed existing methods in the long-horizon driving video generation task. In addition, we also explored STAGE's ability to generate unlimited-length driving videos. We generated 600 frames of high-quality driving videos on the Nuscenes dataset, which far exceeds the maximum length achievable by existing methods.

CVSep 28, 2025
FrameMind: Frame-Interleaved Video Reasoning via Reinforcement Learning

Haonan Ge, Yiwei Wang, Kai-Wei Chang et al.

Current video understanding models rely on fixed frame sampling strategies, processing predetermined visual inputs regardless of the specific reasoning requirements of each question. This static approach limits their ability to adaptively gather visual evidence, leading to suboptimal performance on tasks that require either broad temporal coverage or fine-grained spatial detail. In this paper, we introduce FrameMind, an end-to-end framework trained with reinforcement learning that enables models to dynamically request visual information during reasoning through Frame-Interleaved Chain-of-Thought (FiCOT). Unlike traditional approaches, FrameMind operates in multiple turns where the model alternates between textual reasoning and active visual perception, using tools to extract targeted frames or video clips based on identified knowledge gaps. To train effective dynamic sampling policies, we propose Dynamic Resolution Frame Sampling (DRFS), which exposes models to diverse temporal-spatial trade-offs during learning, and DRFS-GRPO, a group-relative policy optimization algorithm that learns from outcome-based rewards without requiring frame-level annotations. Extensive experiments on challenging benchmarks like MLVU and VideoMME demonstrate that our method significantly outperforms existing models, advancing the state of the art in flexible and efficient video understanding.

LGMay 12, 2025
SpecRouter: Adaptive Routing for Multi-Level Speculative Decoding in Large Language Models

Hang Wu, Jianian Zhu, Yinghui Li et al.

Large Language Models (LLMs) present a critical trade-off between inference quality and computational cost: larger models offer superior capabilities but incur significant latency, while smaller models are faster but less powerful. Existing serving strategies often employ fixed model scales or static two-stage speculative decoding, failing to dynamically adapt to the varying complexities of user requests or fluctuations in system performance. This paper introduces \systemname{}, a novel framework that reimagines LLM inference as an adaptive routing problem solved through multi-level speculative decoding. \systemname{} dynamically constructs and optimizes inference "paths" (chains of models) based on real-time feedback, addressing the limitations of static approaches. Our contributions are threefold: (1) An \textbf{adaptive model chain scheduling} mechanism that leverages performance profiling (execution times) and predictive similarity metrics (derived from token distribution divergence) to continuously select the optimal sequence of draft and verifier models, minimizing predicted latency per generated token. (2) A \textbf{multi-level collaborative verification} framework where intermediate models within the selected chain can validate speculative tokens, reducing the verification burden on the final, most powerful target model. (3) A \textbf{synchronized state management} system providing efficient, consistent KV cache handling across heterogeneous models in the chain, including precise, low-overhead rollbacks tailored for asynchronous batch processing inherent in multi-level speculation. Preliminary experiments demonstrate the validity of our method.

ROMar 6
SuperSuit: An Isomorphic Bimodal Interface for Scalable Mobile Manipulation

Tongqing Chen, Hang Wu, Jiasen Wang et al.

High-quality, long-horizon demonstrations are essential for embodied AI, yet acquiring such data for tightly coupled wheeled mobile manipulators remains a fundamental bottleneck. Unlike fixed-base systems, mobile manipulators require continuous coordination between $SE(2)$ locomotion and precise manipulation, exposing limitations in existing teleoperation and wearable interfaces. We present \textbf{SuperSuit}, a bimodal data acquisition framework that supports both robot-in-the-loop teleoperation and active demonstration under a shared kinematic interface. Both modalities produce structurally identical joint-space trajectories, enabling direct data mixing without modifying downstream policies. For locomotion, SuperSuit maps natural human stepping to continuous planar base velocities, eliminating discrete command switches. For manipulation, it employs a strictly isomorphic wearable arm in both modes, while policy training is formulated in a shift-invariant delta-joint representation to mitigate calibration offsets and structural compliance without inverse kinematics. Real-world experiments on long-horizon mobile manipulation tasks show 2.6$\times$ higher demonstration throughput in active mode compared to a teleoperation baseline, comparable policy performance when substituting teleoperation data with active demonstrations at fixed dataset size, and monotonic performance improvement as active data volume increases. These results indicate that consistent kinematic representations across collection modalities enable scalable data acquisition for long-horizon mobile manipulation.

AIOct 2, 2025
RefineShot: Rethinking Cinematography Understanding with Foundational Skill Evaluation

Hang Wu, Yujun Cai, Haonan Ge et al.

Cinematography understanding refers to the ability to recognize not only the visual content of a scene but also the cinematic techniques that shape narrative meaning. This capability is attracting increasing attention, as it enhances multimodal understanding in real-world applications and underpins coherent content creation in film and media. As the most comprehensive benchmark for this task, ShotBench spans a wide range of cinematic concepts and VQA-style evaluations, with ShotVL achieving state-of-the-art results on it. However, our analysis reveals that ambiguous option design in ShotBench and ShotVL's shortcomings in reasoning consistency and instruction adherence undermine evaluation reliability, limiting fair comparison and hindering future progress. To overcome these issues, we systematically refine ShotBench through consistent option restructuring, conduct the first critical analysis of ShotVL's reasoning behavior, and introduce an extended evaluation protocol that jointly assesses task accuracy and core model competencies. These efforts lead to RefineShot, a refined and expanded benchmark that enables more reliable assessment and fosters future advances in cinematography understanding.

LGSep 22, 2020
Public Health Informatics: Proposing Causal Sequence of Death Using Neural Machine Translation

Yuanda Zhu, Ying Sha, Hang Wu et al.

Each year there are nearly 57 million deaths around the world, with over 2.7 million in the United States. Timely, accurate and complete death reporting is critical in public health, as institutions and government agencies rely on death reports to analyze vital statistics and to formulate responses to communicable diseases. Inaccurate death reporting may result in potential misdirection of public health policies. Determining the causes of death is, nevertheless, challenging even for experienced physicians. To facilitate physicians in accurately reporting causes of death, we present an advanced AI approach to determine a chronically ordered sequence of clinical conditions that lead to death, based on decedent's last hospital discharge record. The sequence of clinical codes on the death report is named as causal chain of death, coded in the tenth revision of International Statistical Classification of Diseases (ICD-10); in line with the ICD-9-CM Official Guidelines for Coding and Reporting, the priority-ordered clinical conditions on the discharge record are coded in ICD-9. We identify three challenges in proposing the causal chain of death: two versions of coding system in clinical codes, medical domain knowledge conflict, and data interoperability. To overcome the first challenge in this sequence-to-sequence problem, we apply neural machine translation models to generate target sequence. Along with three accuracy metrics, we evaluate the quality of generated sequences with the BLEU (BiLingual Evaluation Understudy) score and achieve 16.04 out of 100. To address the second challenge, we incorporate expert-verified medical domain knowledge as constraint in generating output sequence to exclude infeasible causal chains. Lastly, we demonstrate the usability of our work in a Fast Healthcare Interoperability Resources (FHIR) interface to address the third challenge.

IVOct 12, 2019
Improve Model Generalization and Robustness to Dataset Bias with Bias-regularized Learning and Domain-guided Augmentation

Yundong Zhang, Hang Wu, Huiye Liu et al.

Deep Learning has thrived on the emergence of biomedical big data. However, medical datasets acquired at different institutions have inherent bias caused by various confounding factors such as operation policies, machine protocols, treatment preference and etc. As the result, models trained on one dataset, regardless of volume, cannot be confidently utilized for the others. In this study, we investigated model robustness to dataset bias using three large-scale Chest X-ray datasets: first, we assessed the dataset bias using vanilla training baseline; second, we proposed a novel multi-source domain generalization model by (a) designing a new bias-regularized loss function; and (b) synthesizing new data for domain augmentation. We showed that our model significantly outperformed the baseline and other approaches on data from unseen domain in terms of accuracy and various bias measures, without retraining or finetuning. Our method is generally applicable to other biomedical data, providing new algorithms for training models robust to bias for big data analysis and applications. Demo training code is publicly available.

LGJul 6, 2014
Large-Scale Multi-Label Learning with Incomplete Label Assignments

Xiangnan Kong, Zhaoming Wu, Li-Jia Li et al.

Multi-label learning deals with the classification problems where each instance can be assigned with multiple labels simultaneously. Conventional multi-label learning approaches mainly focus on exploiting label correlations. It is usually assumed, explicitly or implicitly, that the label sets for training instances are fully labeled without any missing labels. However, in many real-world multi-label datasets, the label assignments for training instances can be incomplete. Some ground-truth labels can be missed by the labeler from the label set. This problem is especially typical when the number instances is very large, and the labeling cost is very high, which makes it almost impossible to get a fully labeled training set. In this paper, we study the problem of large-scale multi-label learning with incomplete label assignments. We propose an approach, called MPU, based upon positive and unlabeled stochastic gradient descent and stacked models. Unlike prior works, our method can effectively and efficiently consider missing labels and label correlations simultaneously, and is very scalable, that has linear time complexities over the size of the data. Extensive experiments on two real-world multi-label datasets show that our MPU model consistently outperform other commonly-used baselines.