Jing Qin

Haoran Zhou, Honghua Chen, Yingkui Zhang et al.

Point normal, as an intrinsic geometric property of 3D objects, not only serves conventional geometric tasks such as surface consolidation and reconstruction, but also facilitates cutting-edge learning-based techniques for shape analysis and generation. In this paper, we propose a normal refinement network, called Refine-Net, to predict accurate normals for noisy point clouds. Traditional normal estimation wisdom heavily depends on priors such as surface shapes or noise distributions, while learning-based solutions settle for single types of hand-crafted features. Differently, our network is designed to refine the initial normal of each point by extracting additional information from multiple feature representations. To this end, several feature modules are developed and incorporated into Refine-Net by a novel connection module. Besides the overall network architecture of Refine-Net, we propose a new multi-scale fitting patch selection scheme for the initial normal estimation, by absorbing geometry domain knowledge. Also, Refine-Net is a generic normal estimation framework: 1) point normals obtained from other methods can be further refined, and 2) any feature module related to the surface geometric structures can be potentially integrated into the framework. Qualitative and quantitative evaluations demonstrate the clear superiority of Refine-Net over the state-of-the-arts on both synthetic and real-scanned datasets. Our code is available at https://github.com/hrzhou2/refinenet.

Haoxin Yang, Xuemiao Xu, Cheng Xu et al.

Reversible face anonymization, unlike traditional face pixelization, seeks to replace sensitive identity information in facial images with synthesized alternatives, preserving privacy without sacrificing image clarity. Traditional methods, such as encoder-decoder networks, often result in significant loss of facial details due to their limited learning capacity. Additionally, relying on latent manipulation in pre-trained GANs can lead to changes in ID-irrelevant attributes, adversely affecting data utility due to GAN inversion inaccuracies. This paper introduces G\textsuperscript{2}Face, which leverages both generative and geometric priors to enhance identity manipulation, achieving high-quality reversible face anonymization without compromising data utility. We utilize a 3D face model to extract geometric information from the input face, integrating it with a pre-trained GAN-based decoder. This synergy of generative and geometric priors allows the decoder to produce realistic anonymized faces with consistent geometry. Moreover, multi-scale facial features are extracted from the original face and combined with the decoder using our novel identity-aware feature fusion blocks (IFF). This integration enables precise blending of the generated facial patterns with the original ID-irrelevant features, resulting in accurate identity manipulation. Extensive experiments demonstrate that our method outperforms existing state-of-the-art techniques in face anonymization and recovery, while preserving high data utility. Code is available at https://github.com/Harxis/G2Face.

Yazhou Zhang, Mengyao Wang, Youxi Wu et al.

Large language models (LLMs) and their variants have shown extraordinary efficacy across numerous downstream natural language processing (NLP) tasks, which has presented a new vision for the development of NLP. Despite their remarkable performance in natural language generating (NLG), LLMs lack a distinct focus on the emotion understanding domain. As a result, using LLMs for emotion recognition may lead to suboptimal and inadequate precision. Another limitation of LLMs is that they are typical trained without leveraging multi-modal information. To overcome these limitations, we propose DialogueLLM, a context and emotion knowledge tuned LLM that is obtained by fine-tuning LLaMA models with 13,638 multi-modal (i.e., texts and videos) emotional dialogues. The visual information is considered as the supplementary knowledge to construct high-quality instructions. We offer a comprehensive evaluation of our proposed model on three benchmarking emotion recognition in conversations (ERC) datasets and compare the results against the SOTA baselines and other SOTA LLMs. Additionally, DialogueLLM-7B can be easily trained using LoRA on a 40GB A100 GPU in 5 hours, facilitating reproducibility for other researchers.

Zhaohu Xing, Sicheng Yang, Sixiang Chen et al.

Multi-modal magnetic resonance imaging (MRI) provides rich, complementary information for analyzing diseases. However, the practical challenges of acquiring multiple MRI modalities, such as cost, scan time, and safety considerations, often result in incomplete datasets. This affects both the quality of diagnosis and the performance of deep learning models trained on such data. Recent advancements in generative adversarial networks (GANs) and denoising diffusion models have shown promise in natural and medical image-to-image translation tasks. However, the complexity of training GANs and the computational expense associated with diffusion models hinder their development and application in this task. To address these issues, we introduce a Cross-conditioned Diffusion Model (CDM) for medical image-to-image translation. The core idea of CDM is to use the distribution of target modalities as guidance to improve synthesis quality while achieving higher generation efficiency compared to conventional diffusion models. First, we propose a Modality-specific Representation Model (MRM) to model the distribution of target modalities. Then, we design a Modality-decoupled Diffusion Network (MDN) to efficiently and effectively learn the distribution from MRM. Finally, a Cross-conditioned UNet (C-UNet) with a Condition Embedding module is designed to synthesize the target modalities with the source modalities as input and the target distribution for guidance. Extensive experiments conducted on the BraTS2023 and UPenn-GBM benchmark datasets demonstrate the superiority of our method.

Ben Yao, Yazhou Zhang, Qiuchi Li et al.

Elaborating a series of intermediate reasoning steps significantly improves the ability of large language models (LLMs) to solve complex problems, as such steps would evoke LLMs to think sequentially. However, human sarcasm understanding is often considered an intuitive and holistic cognitive process, in which various linguistic, contextual, and emotional cues are integrated to form a comprehensive understanding, in a way that does not necessarily follow a step-by-step fashion. To verify the validity of this argument, we introduce a new prompting framework (called SarcasmCue) containing four sub-methods, viz. chain of contradiction (CoC), graph of cues (GoC), bagging of cues (BoC) and tensor of cues (ToC), which elicits LLMs to detect human sarcasm by considering sequential and non-sequential prompting methods. Through a comprehensive empirical comparison on four benchmarks, we highlight three key findings: (1) CoC and GoC show superior performance with more advanced models like GPT-4 and Claude 3.5, with an improvement of 3.5%. (2) ToC significantly outperforms other methods when smaller LLMs are evaluated, boosting the F1 score by 29.7% over the best baseline. (3) Our proposed framework consistently pushes the state-of-the-art (i.e., ToT) by 4.2%, 2.0%, 29.7%, and 58.2% in F1 scores across four datasets. This demonstrates the effectiveness and stability of the proposed framework.

Chenyu Lian, Hong-Yu Zhou, Dongyun Liang et al.

Medical vision-language alignment through cross-modal contrastive learning shows promising performance in image-text matching tasks, such as retrieval and zero-shot classification. However, conventional cross-modal contrastive learning (CLIP-based) methods suffer from suboptimal visual representation capabilities, which also limits their effectiveness in vision-language alignment. In contrast, although the models pretrained via multimodal masked modeling struggle with direct cross-modal matching, they excel in visual representation. To address this contradiction, we propose ALTA (ALign Through Adapting), an efficient medical vision-language alignment method that utilizes only about 8% of the trainable parameters and less than 1/5 of the computational consumption required for masked record modeling. ALTA achieves superior performance in vision-language matching tasks like retrieval and zero-shot classification by adapting the pretrained vision model from masked record modeling. Additionally, we integrate temporal-multiview radiograph inputs to enhance the information consistency between radiographs and their corresponding descriptions in reports, further improving the vision-language alignment. Experimental evaluations show that ALTA outperforms the best-performing counterpart by over 4% absolute points in text-to-image accuracy and approximately 6% absolute points in image-to-text retrieval accuracy. The adaptation of vision-language models during efficient alignment also promotes better vision and language understanding. Code is publicly available at https://github.com/DopamineLcy/ALTA.

Xing He, Zhe Zhu, Liangliang Nan et al.

Conventional methods for point cloud completion, typically trained on synthetic datasets, face significant challenges when applied to out-of-distribution real-world scans. In this paper, we propose an effective yet simple source-free domain adaptation framework for point cloud completion, termed \textbf{PointSFDA}. Unlike unsupervised domain adaptation that reduces the domain gap by directly leveraging labeled source data, PointSFDA uses only a pretrained source model and unlabeled target data for adaptation, avoiding the need for inaccessible source data in practical scenarios. Being the first source-free domain adaptation architecture for point cloud completion, our method offers two core contributions. First, we introduce a coarse-to-fine distillation solution to explicitly transfer the global geometry knowledge learned from the source dataset. Second, as noise may be introduced due to domain gaps, we propose a self-supervised partial-mask consistency training strategy to learn local geometry information in the target domain. Extensive experiments have validated that our method significantly improves the performance of state-of-the-art networks in cross-domain shape completion. Our code is available at \emph{\textcolor{magenta}{https://github.com/Starak-x/PointSFDA}}.

Haoran Zhou, Yidan Feng, Mingsheng Fang et al.

Convolution on 3D point clouds that generalized from 2D grid-like domains is widely researched yet far from perfect. The standard convolution characterises feature correspondences indistinguishably among 3D points, presenting an intrinsic limitation of poor distinctive feature learning. In this paper, we propose Adaptive Graph Convolution (AdaptConv) which generates adaptive kernels for points according to their dynamically learned features. Compared with using a fixed/isotropic kernel, AdaptConv improves the flexibility of point cloud convolutions, effectively and precisely capturing the diverse relations between points from different semantic parts. Unlike popular attentional weight schemes, the proposed AdaptConv implements the adaptiveness inside the convolution operation instead of simply assigning different weights to the neighboring points. Extensive qualitative and quantitative evaluations show that our method outperforms state-of-the-art point cloud classification and segmentation approaches on several benchmark datasets. Our code is available at https://github.com/hrzhou2/AdaptConv-master.

Quande Liu, Cheng Chen, Jing Qin et al.

Federated learning allows distributed medical institutions to collaboratively learn a shared prediction model with privacy protection. While at clinical deployment, the models trained in federated learning can still suffer from performance drop when applied to completely unseen hospitals outside the federation. In this paper, we point out and solve a novel problem setting of federated domain generalization (FedDG), which aims to learn a federated model from multiple distributed source domains such that it can directly generalize to unseen target domains. We present a novel approach, named as Episodic Learning in Continuous Frequency Space (ELCFS), for this problem by enabling each client to exploit multi-source data distributions under the challenging constraint of data decentralization. Our approach transmits the distribution information across clients in a privacy-protecting way through an effective continuous frequency space interpolation mechanism. With the transferred multi-source distributions, we further carefully design a boundary-oriented episodic learning paradigm to expose the local learning to domain distribution shifts and particularly meet the challenges of model generalization in medical image segmentation scenario. The effectiveness of our method is demonstrated with superior performance over state-of-the-arts and in-depth ablation experiments on two medical image segmentation tasks. The code is available at "https://github.com/liuquande/FedDG-ELCFS".

Zheng Han, Jun Zhou, Jialun Pei et al.

In augmented reality (AR)-guided surgical navigation, preoperative organ models are superimposed onto the patient's intraoperative anatomy to visualize critical structures such as vessels and tumors. Accurate deformation modeling is essential to maintain the reliability of AR overlays by ensuring alignment between preoperative models and the dynamically changing anatomy. Although the finite element method (FEM) offers physically plausible modeling, its high computational cost limits intraoperative applicability. Moreover, existing algorithms often fail to handle large anatomical changes, such as those induced by pneumoperitoneum or ligament dissection, leading to inaccurate anatomical correspondences and compromised AR guidance. To address these challenges, we propose a data-driven biomechanics algorithm that preserves FEM-level accuracy while improving computational efficiency. In addition, we introduce a novel human-in-the-loop mechanism into the deformation modeling process. This enables surgeons to interactively provide prompts to correct anatomical misalignments, thereby incorporating clinical expertise and allowing the model to adapt dynamically to complex surgical scenarios. Experiments on a publicly available dataset demonstrate that our algorithm achieves a mean target registration error of 3.42 mm. Incorporating surgeon prompts through the interactive framework further reduces the error to 2.78 mm, surpassing state-of-the-art methods in volumetric accuracy. These results highlight the ability of our framework to deliver efficient and accurate deformation modeling while enhancing surgeon-algorithm collaboration, paving the way for safer and more reliable computer-assisted surgeries.

Shu Yang, Fengtao Zhou, Leon Mayer et al.

Computer-Assisted Intervention (CAI) has the potential to revolutionize modern surgery, with surgical scene understanding serving as a critical component in supporting decision-making, improving procedural efficacy, and ensuring intraoperative safety. While existing AI-driven approaches alleviate annotation burdens via self-supervised spatial representation learning, their lack of explicit temporal modeling during pre-training fundamentally restricts the capture of dynamic surgical contexts, resulting in incomplete spatiotemporal understanding. In this work, we introduce the first video-level surgical pre-training framework that enables joint spatiotemporal representation learning from large-scale surgical video data. To achieve this, we constructed a large-scale surgical video dataset comprising 3,650 videos and approximately 3.55 million frames, spanning more than 20 surgical procedures and over 10 anatomical structures. Building upon this dataset, we propose SurgVISTA (Surgical Video-level Spatial-Temporal Architecture), a reconstruction-based pre-training method that captures intricate spatial structures and temporal dynamics through joint spatiotemporal modeling. Additionally, SurgVISTA incorporates image-level knowledge distillation guided by a surgery-specific expert to enhance the learning of fine-grained anatomical and semantic features. To validate its effectiveness, we established a comprehensive benchmark comprising 13 video-level datasets spanning six surgical procedures across four tasks. Extensive experiments demonstrate that SurgVISTA consistently outperforms both natural- and surgical-domain pre-trained models, demonstrating strong potential to advance intelligent surgical systems in clinically meaningful scenarios.

Yazhou Zhang, Chunwang Zou, Qimeng Liu et al.

Can multi-modal large models (MLMs) that can ``see'' an image be said to ``understand'' it? Drawing inspiration from Searle's Chinese Room, we propose the \textbf{Visual Room} argument: a system may process and describe every detail of visual inputs by following algorithmic rules, without genuinely comprehending the underlying intention. This dilemma challenges the prevailing assumption that perceptual mastery implies genuine understanding. In implementation, we introduce a two-tier evaluation framework spanning perception and cognition. The perception component evaluates whether MLMs can accurately capture the surface-level details of visual contents, where the cognitive component examines their ability to infer sarcasm polarity. To support this framework, We further introduce a high-quality multi-modal sarcasm dataset comprising both 924 static images and 100 dynamic videos. All sarcasm labels are annotated by the original authors and verified by independent reviewers to ensure clarity and consistency. We evaluate eight state-of-the-art (SoTA) MLMs. Our results highlight three key findings: (1) MLMs demonstrate high accuracy in visual perception; (2) even with correct perception, MLMs exhibit an average error rate of ~17.1\% in sarcasm understanding, revealing a significant gap between seeing and understanding; (3) this gap stems from weaknesses in context integration, emotional reasoning, and pragmatic inference. This work provides empirical grounding for the proposed Visual Room argument and offers a new evaluation paradigm for MLMs.

Yu Liu, Hao Tang, Haiqi Zhang et al.

Out-of-distribution (OOD) detection is crucial for ensuring the reliability and safety of machine learning models in real-world applications. While zero-shot OOD detection, which requires no training on in-distribution (ID) data, has become feasible with the emergence of vision-language models like CLIP, existing methods primarily focus on semantic matching and fail to fully capture distributional discrepancies. To address these limitations, we propose OT-DETECTOR, a novel framework that employs Optimal Transport (OT) to quantify both semantic and distributional discrepancies between test samples and ID labels. Specifically, we introduce cross-modal transport mass and transport cost as semantic-wise and distribution-wise OOD scores, respectively, enabling more robust detection of OOD samples. Additionally, we present a semantic-aware content refinement (SaCR) module, which utilizes semantic cues from ID labels to amplify the distributional discrepancy between ID and hard OOD samples. Extensive experiments on several benchmarks demonstrate that OT-DETECTOR achieves state-of-the-art performance across various OOD detection tasks, particularly in challenging hard-OOD scenarios.

Jingguo Qu, Xinyang Han, Man-Lik Chui et al.

Automatic lymph node segmentation is the cornerstone for advances in computer vision tasks for early detection and staging of cancer. Traditional segmentation methods are constrained by manual delineation and variability in operator proficiency, limiting their ability to achieve high accuracy. The introduction of deep learning technologies offers new possibilities for improving the accuracy of lymph node image analysis. This study evaluates the application of deep learning in lymph node segmentation and discusses the methodologies of various deep learning architectures such as convolutional neural networks, encoder-decoder networks, and transformers in analyzing medical imaging data across different modalities. Despite the advancements, it still confronts challenges like the shape diversity of lymph nodes, the scarcity of accurately labeled datasets, and the inadequate development of methods that are robust and generalizable across different imaging modalities. To the best of our knowledge, this is the first study that provides a comprehensive overview of the application of deep learning techniques in lymph node segmentation task. Furthermore, this study also explores potential future research directions, including multimodal fusion techniques, transfer learning, and the use of large-scale pre-trained models to overcome current limitations while enhancing cancer diagnosis and treatment planning strategies.

Yazhou Zhang, Qimeng Liu, Qiuchi Li et al.

Evaluating the value alignment of large language models (LLMs) has traditionally relied on single-sentence adversarial prompts, which directly probe models with ethically sensitive or controversial questions. However, with the rapid advancements in AI safety techniques, models have become increasingly adept at circumventing these straightforward tests, limiting their effectiveness in revealing underlying biases and ethical stances. To address this limitation, we propose an upgraded value alignment benchmark that moves beyond single-sentence prompts by incorporating multi-turn dialogues and narrative-based scenarios. This approach enhances the stealth and adversarial nature of the evaluation, making it more robust against superficial safeguards implemented in modern LLMs. We design and implement a dataset that includes conversational traps and ethically ambiguous storytelling, systematically assessing LLMs' responses in more nuanced and context-rich settings. Experimental results demonstrate that this enhanced methodology can effectively expose latent biases that remain undetected in traditional single-shot evaluations. Our findings highlight the necessity of contextual and dynamic testing for value alignment in LLMs, paving the way for more sophisticated and realistic assessments of AI ethics and safety.

Yazhou Zhang, Chunwang Zou, Bo Wang et al.

Multimodal sarcasm understanding is a high-order cognitive task. Although large language models (LLMs) have shown impressive performance on many downstream NLP tasks, growing evidence suggests that they struggle with sarcasm understanding. In this paper, we propose Commander-GPT, a modular decision routing framework inspired by military command theory. Rather than relying on a single LLM's capability, Commander-GPT orchestrates a team of specialized LLM agents where each agent will be selectively assigned to a focused sub-task such as context modeling, sentiment analysis, etc. Their outputs are then routed back to the commander, which integrates the information and performs the final sarcasm judgment. To coordinate these agents, we introduce three types of centralized commanders: (1) a trained lightweight encoder-based commander (e.g., multi-modal BERT); (2) four small autoregressive language models, serving as moderately capable commanders (e.g., DeepSeek-VL); (3) two large LLM-based commander (Gemini Pro and GPT-4o) that performs task routing, output aggregation, and sarcasm decision-making in a zero-shot fashion. We evaluate Commander-GPT on the MMSD and MMSD 2.0 benchmarks, comparing five prompting strategies. Experimental results show that our framework achieves 4.4% and 11.7% improvement in F1 score over state-of-the-art (SoTA) baselines on average, demonstrating its effectiveness.

Zi Wang, Fanwen Wang, Chen Qin et al.

Cardiac magnetic resonance imaging (MRI) has emerged as a clinically gold-standard technique for diagnosing cardiac diseases, thanks to its ability to provide diverse information with multiple modalities and anatomical views. Accelerated cardiac MRI is highly expected to achieve time-efficient and patient-friendly imaging, and then advanced image reconstruction approaches are required to recover high-quality, clinically interpretable images from undersampled measurements. However, the lack of publicly available cardiac MRI k-space dataset in terms of both quantity and diversity has severely hindered substantial technological progress, particularly for data-driven artificial intelligence. Here, we provide a standardized, diverse, and high-quality CMRxRecon2024 dataset to facilitate the technical development, fair evaluation, and clinical transfer of cardiac MRI reconstruction approaches, towards promoting the universal frameworks that enable fast and robust reconstructions across different cardiac MRI protocols in clinical practice. To the best of our knowledge, the CMRxRecon2024 dataset is the largest and most protocal-diverse publicly available cardiac k-space dataset. It is acquired from 330 healthy volunteers, covering commonly used modalities, anatomical views, and acquisition trajectories in clinical cardiac MRI workflows. Besides, an open platform with tutorials, benchmarks, and data processing tools is provided to facilitate data usage, advanced method development, and fair performance evaluation.

Long Lei, Jun Zhou, Jialun Pei et al.

A comprehensive guidance view for cardiac interventional surgery can be provided by the real-time fusion of the intraoperative 2D images and preoperative 3D volume based on the ultrasound frame-to-volume registration. However, cardiac ultrasound images are characterized by a low signal-to-noise ratio and small differences between adjacent frames, coupled with significant dimension variations between 2D frames and 3D volumes to be registered, resulting in real-time and accurate cardiac ultrasound frame-to-volume registration being a very challenging task. This paper introduces a lightweight end-to-end Cardiac Ultrasound frame-to-volume Registration network, termed CU-Reg. Specifically, the proposed model leverages epicardium prompt-guided anatomical clues to reinforce the interaction of 2D sparse and 3D dense features, followed by a voxel-wise local-global aggregation of enhanced features, thereby boosting the cross-dimensional matching effectiveness of low-quality ultrasound modalities. We further embed an inter-frame discriminative regularization term within the hybrid supervised learning to increase the distinction between adjacent slices in the same ultrasound volume to ensure registration stability. Experimental results on the reprocessed CAMUS dataset demonstrate that our CU-Reg surpasses existing methods in terms of registration accuracy and efficiency, meeting the guidance requirements of clinical cardiac interventional surgery.

Muhao Chen, Jing Qin

In the design of tensegrity structures, traditional form-finding methods utilize kinematic and static approaches to identify geometric configurations that achieve equilibrium. However, these methods often fall short when applied to actual physical models due to imperfections in the manufacturing of structural elements, assembly errors, and material non-linearities. In this work, we develop a deep neural network (DNN) approach to predict the geometric configurations and physical properties-such as nodal coordinates, member forces, and natural frequencies-of any tensegrity structures in equilibrium states. First, we outline the analytical governing equations for tensegrity structures, covering statics involving nodal coordinates and member forces, as well as modal information. Next, we propose a data-driven framework for training an appropriate DNN model capable of simultaneously predicting tensegrity forms and physical properties, thereby circumventing the need to solve equilibrium equations. For validation, we analyze three tensegrity structures, including a tensegrity D-bar, prism, and lander, demonstrating that our approach can identify approximation systems with relatively very small output errors. This technique is applicable to a wide range of tensegrity structures, particularly in real-world construction, and can be extended to address additional challenges in identifying structural physics information.

Cheng Chen, Qi Dou, Yueming Jin et al.

Accurate medical image segmentation commonly requires effective learning of the complementary information from multimodal data. However, in clinical practice, we often encounter the problem of missing imaging modalities. We tackle this challenge and propose a novel multimodal segmentation framework which is robust to the absence of imaging modalities. Our network uses feature disentanglement to decompose the input modalities into the modality-specific appearance code, which uniquely sticks to each modality, and the modality-invariant content code, which absorbs multimodal information for the segmentation task. With enhanced modality-invariance, the disentangled content code from each modality is fused into a shared representation which gains robustness to missing data. The fusion is achieved via a learning-based strategy to gate the contribution of different modalities at different locations. We validate our method on the important yet challenging multimodal brain tumor segmentation task with the BRATS challenge dataset. With competitive performance to the state-of-the-art approaches for full modality, our method achieves outstanding robustness under various missing modality(ies) situations, significantly exceeding the state-of-the-art method by over 16% in average for Dice on whole tumor segmentation.

Xueying Shi, Qi Dou, Cheng Xue et al.

Automated skin lesion analysis is very crucial in clinical practice, as skin cancer is among the most common human malignancy. Existing approaches with deep learning have achieved remarkable performance on this challenging task, however, heavily relying on large-scale labelled datasets. In this paper, we present a novel active learning framework for cost-effective skin lesion analysis. The goal is to effectively select and utilize much fewer labelled samples, while the network can still achieve state-of-the-art performance. Our sample selection criteria complementarily consider both informativeness and representativeness, derived from decoupled aspects of measuring model certainty and covering sample diversity. To make wise use of the selected samples, we further design a simple yet effective strategy to aggregate intra-class images in pixel space, as a new form of data augmentation. We validate our proposed method on data of ISIC 2017 Skin Lesion Classification Challenge for two tasks. Using only up to 50% of samples, our approach can achieve state-of-the-art performances on both tasks, which are comparable or exceeding the accuracies with full-data training, and outperform other well-known active learning methods by a large margin.

Qi Dou, Hao Chen, Yueming Jin et al.

In this paper, we propose a novel framework with 3D convolutional networks (ConvNets) for automated detection of pulmonary nodules from low-dose CT scans, which is a challenging yet crucial task for lung cancer early diagnosis and treatment. Different from previous standard ConvNets, we try to tackle the severe hard/easy sample imbalance problem in medical datasets and explore the benefits of localized annotations to regularize the learning, and hence boost the performance of ConvNets to achieve more accurate detections. Our proposed framework consists of two stages: 1) candidate screening, and 2) false positive reduction. In the first stage, we establish a 3D fully convolutional network, effectively trained with an online sample filtering scheme, to sensitively and rapidly screen the nodule candidates. In the second stage, we design a hybrid-loss residual network which harnesses the location and size information as important cues to guide the nodule recognition procedure. Experimental results on the public large-scale LUNA16 dataset demonstrate superior performance of our proposed method compared with state-of-the-art approaches for the pulmonary nodule detection task.