Lei He

Jiawei Yang, Yao Zhang, Yuan Liang et al.

Deep learning models are notoriously data-hungry. Thus, there is an urging need for data-efficient techniques in medical image analysis, where well-annotated data are costly and time consuming to collect. Motivated by the recently revived "Copy-Paste" augmentation, we propose TumorCP, a simple but effective object-level data augmentation method tailored for tumor segmentation. TumorCP is online and stochastic, providing unlimited augmentation possibilities for tumors' subjects, locations, appearances, as well as morphologies. Experiments on kidney tumor segmentation task demonstrate that TumorCP surpasses the strong baseline by a remarkable margin of 7.12% on tumor Dice. Moreover, together with image-level data augmentation, it beats the current state-of-the-art by 2.32% on tumor Dice. Comprehensive ablation studies are performed to validate the effectiveness of TumorCP. Meanwhile, we show that TumorCP can lead to striking improvements in extremely low-data regimes. Evaluated with only 10% labeled data, TumorCP significantly boosts tumor Dice by 21.87%. To the best of our knowledge, this is the very first work exploring and extending the "Copy-Paste" design in medical imaging domain. Code is available at: https://github.com/YaoZhang93/TumorCP.

Yinqiu Liu, Kai Qian, Jianli Chen et al.

As an emerging technology, blockchain has achieved great success in numerous application scenarios, from intelligent healthcare to smart cities. However, a long-standing bottleneck hindering its further development is the massive resource consumption attributed to the distributed storage and computation methods. This makes blockchain suffer from insufficient performance and poor scalability. Here, we analyze the recent blockchain techniques and demonstrate that the potential of widely-adopted consensus-based scaling is seriously limited, especially in the current era when Moore's law-based hardware scaling is about to end. We achieve this by developing an open-source benchmarking tool, called Prism, for investigating the key factors causing low resource efficiency and then discuss various topology and hardware innovations which could help to scale up blockchain. To the best of our knowledge, this is the first in-depth study that explores the next-generation scaling strategies by conducting large-scale and comprehensive benchmarking.

Yichen Shi, Zhuofu Tao, Yuhao Gao et al.

Current multimodal large language models (MLLMs) struggle to understand circuit schematics due to their limited recognition capabilities. This could be attributed to the lack of high-quality schematic-netlist training data. Existing work such as AMSnet applies schematic parsing to generate netlists. However, these methods rely on hard-coded heuristics and are difficult to apply to complex or noisy schematics in this paper. We therefore propose a novel net detection mechanism based on segmentation with high robustness. The proposed method also recovers positional information, allowing digital reconstruction of schematics. We then expand AMSnet dataset with schematic images from various sources and create AMSnet 2.0. AMSnet 2.0 contains 2,686 circuits with schematic images, Spectre-formatted netlists, OpenAccess digital schematics, and positional information for circuit components and nets, whereas AMSnet only includes 792 circuits with SPICE netlists but no digital schematics.

Yuan Liang, Weinan Song, Jiawei Yang et al.

3D teeth reconstruction from X-ray is important for dental diagnosis and many clinical operations. However, no existing work has explored the reconstruction of teeth for a whole cavity from a single panoramic radiograph. Different from single object reconstruction from photos, this task has the unique challenge of constructing multiple objects at high resolutions. To conquer this task, we develop a novel ConvNet X2Teeth that decomposes the task into teeth localization and single-shape estimation. We also introduce a patch-based training strategy, such that X2Teeth can be end-to-end trained for optimal performance. Extensive experiments show that our method can successfully estimate the 3D structure of the cavity and reflect the details for each tooth. Moreover, X2Teeth achieves a reconstruction IoU of 0.681, which significantly outperforms the encoder-decoder method by $1.71X and the retrieval-based method by $1.52X. Our method can also be promising for other multi-anatomy 3D reconstruction tasks.

Yuan Liang, Weinan Song, Jiawei Yang et al.

Convolutional networks (ConvNets) have achieved promising accuracy for various anatomical segmentation tasks. Despite the success, these methods can be sensitive to data appearance variations. Considering the large variability of scans caused by artifacts, pathologies, and scanning setups, robust ConvNets are vital for clinical applications, while have not been fully explored. In this paper, we propose to mitigate the challenge by enabling ConvNets' awareness of the underlying anatomical invariances among imaging scans. Specifically, we introduce a fully convolutional Constraint Adoption Module (CAM) that incorporates probabilistic atlas priors as explicit constraints for predictions over a locally connected Conditional Random Field (CFR), which effectively reinforces the anatomical consistency of the labeling outputs. We design the CAM to be flexible for boosting various ConvNet, and compact for co-optimizing with ConvNets for fusion parameters that leads to the optimal performance. We show the advantage of such atlas priors fusion is two-fold with two brain parcellation tasks. First, our models achieve state-of-the-art accuracy among ConvNet-based methods on both datasets, by significantly reducing structural abnormalities of predictions. Second, we can largely boost the robustness of existing ConvNets, proved by: (i) testing on scans with synthetic pathologies, and (ii) training and evaluation on scans of different scanning setups across datasets. Our method is proposing to be easily adopted to existing ConvNets by fine-tuning with CAM plugged in for accuracy and robustness boosts.

Jiawei Yang, Yuan Liang, Yao Zhang et al.

The ability of deep learning to predict with uncertainty is recognized as key for its adoption in clinical routines. Moreover, performance gain has been enabled by modelling uncertainty according to empirical evidence. While previous work has widely discussed the uncertainty estimation in segmentation and classification tasks, its application on bounding-box-based detection has been limited, mainly due to the challenge of bounding box aligning. In this work, we explore to augment a 2.5D detection CNN with two different bounding-box-level (or instance-level) uncertainty estimates, i.e., predictive variance and Monte Carlo (MC) sample variance. Experiments are conducted for lung nodule detection on LUNA16 dataset, a task where significant semantic ambiguities can exist between nodules and non-nodules. Results show that our method improves the evaluating score from 84.57% to 88.86% by utilizing a combination of both types of variances. Moreover, we show the generated uncertainty enables superior operating points compared to using the probability threshold only, and can further boost the performance to 89.52%. Example nodule detections are visualized to further illustrate the advantages of our method.

Weinan Song, Yuan Liang, Jiawei Yang et al.

Panoramic X-ray (PX) provides a 2D picture of the patient's mouth in a panoramic view to help dentists observe the invisible disease inside the gum. However, it provides limited 2D information compared with cone-beam computed tomography (CBCT), another dental imaging method that generates a 3D picture of the oral cavity but with more radiation dose and a higher price. Consequently, it is of great interest to reconstruct the 3D structure from a 2D X-ray image, which can greatly explore the application of X-ray imaging in dental surgeries. In this paper, we propose a framework, named Oral-3D, to reconstruct the 3D oral cavity from a single PX image and prior information of the dental arch. Specifically, we first train a generative model to learn the cross-dimension transformation from 2D to 3D. Then we restore the shape of the oral cavity with a deformation module with the dental arch curve, which can be obtained simply by taking a photo of the patient's mouth. To be noted, Oral-3D can restore both the density of bony tissues and the curved mandible surface. Experimental results show that Oral-3D can efficiently and effectively reconstruct the 3D oral structure and show critical information in clinical applications, e.g., tooth pulling and dental implants. To the best of our knowledge, we are the first to explore this domain transformation problem between these two imaging methods.

Yuan Liang, Weinan Song, J. P. Dym et al.

Label propagation is a popular technique for anatomical segmentation. In this work, we propose a novel deep framework for label propagation based on non-local label fusion. Our framework, named CompareNet, incorporates subnets for both extracting discriminating features, and learning the similarity measure, which lead to accurate segmentation. We also introduce the voxel-wise classification as an unary potential to the label fusion function, for alleviating the search failure issue of the existing non-local fusion strategies. Moreover, CompareNet is end-to-end trainable, and all the parameters are learnt together for the optimal performance. By evaluating CompareNet on two public datasets IBSRv2 and MICCAI 2012 for brain segmentation, we show it outperforms state-of-the-art methods in accuracy, while being robust to pathologies.

Shuai Han, Sai Xu, Weixiao Meng et al.

An artificial-noise (AN)-aided beamformer specific to correlated main and wiretap channels is designed in this paper. We consider slow-fading multiple-input-single-output (MISO) wiretap channels with a passive single-antenna eavesdropper, in which independent transmitter-side and correlated receiver-side are assumed. Additionally, the source has accurate main channel information and statistical wiretap channel information. To reduce the secrecy loss due to receiver-side correlation, this paper proposes the scheme of channel-correlation-enabled transmit optimization. Particularly, the correlation is viewed as a resource to acquire more knowledge about wiretap channel. Based on this, the statistical distribution of wiretap channel is described more precisely. Then, the power of AN in the null space of main channel is placed more reasonably instead of simple uniform distribution and an elaborate beamformer for the information-bearing signal is designed. Finally, an efficient algorithm for power allocation between the information-bearing signal and the AN is developed. Simulation results show that the secrecy rate under transmit power and secrecy outage constraint is improved.

Haohan Guo, Frank K. Soong, Lei He et al.

End-to-end, autoregressive model-based TTS has shown significant performance improvements over the conventional one. However, the autoregressive module training is affected by the exposure bias, or the mismatch between the different distributions of real and predicted data. While real data is available in training, but in testing, only predicted data is available to feed the autoregressive module. By introducing both real and generated data sequences in training, we can alleviate the effects of the exposure bias. We propose to use Generative Adversarial Network (GAN) along with the key idea of Professor Forcing in training. A discriminator in GAN is jointly trained to equalize the difference between real and predicted data. In AB subjective listening test, the results show that the new approach is preferred over the standard transfer learning with a CMOS improvement of 0.1. Sentence level intelligibility tests show significant improvement in a pathological test set. The GAN-trained new model is also more stable than the baseline to produce better alignments for the Tacotron output.