Shuang Zhou

Shuang Zhou, Xiao Huang, Ninghao Liu et al.

Graph anomaly detection (GAD) is a vital task since even a few anomalies can pose huge threats to benign users. Recent semi-supervised GAD methods, which can effectively leverage the available labels as prior knowledge, have achieved superior performances than unsupervised methods. In practice, people usually need to identify anomalies on new (sub)graphs to secure their business, but they may lack labels to train an effective detection model. One natural idea is to directly adopt a trained GAD model to the new (sub)graph for testing. However, we find that existing semi-supervised GAD methods suffer from poor generalization issue, i.e., well-trained models could not perform well on an unseen area (i.e., not accessible in training) of the same graph. It may cause great troubles. In this paper, we base on the phenomenon and propose a general and novel research problem of generalized graph anomaly detection that aims to effectively identify anomalies on both the training-domain graph and unseen testing graph to eliminate potential dangers. Nevertheless, it is a challenging task since only limited labels are available, and the normal background may differ between training and testing data. Accordingly, we propose a data augmentation method named \textit{AugAN} (\uline{Aug}mentation for \uline{A}nomaly and \uline{N}ormal distributions) to enrich training data and boost the generalizability of GAD models. Experiments verify the effectiveness of our method in improving model generalizability.

Zhu Wang, Junnan Dong, Shuang Zhou et al.

Graph anomaly detection (GAD) is widely applied in many areas, such as financial fraud detection and social spammer detection. Anomalous nodes in the graph not only impact their own communities but also create a ripple effect on neighbors throughout the graph structure. Detecting anomalous nodes in complex graphs has been a challenging task. While existing GAD methods assume all labels are correct, real-world scenarios often involve inaccurate annotations. These noisy labels can severely degrade GAD performance because, with anomalies representing a minority class, even a small number of mislabeled instances can disproportionately interfere with detection models. Cutting edges to mitigate the negative effects of noisy labels is a good option; however, it has both positive and negative influences and also presents an issue of weak supervision. To perform effective GAD with noisy labels, we propose REinforced Graph Anomaly Detector (REGAD) by pruning the edges of candidate nodes potentially with mistaken labels. Moreover, we design the performance feedback based on strategically crafted confident labels to guide the cutting process, ensuring optimal results. Specifically, REGAD contains two novel components. (i) A tailored policy network, which involves two-step actions to remove negative effect propagation step by step. (ii) A policy-in-the-loop mechanism to identify suitable edge removal strategies that control the propagation of noise on the graph and estimate the updated structure to obtain reliable pseudo labels iteratively. Experiments on three real-world datasets demonstrate that REGAD outperforms all baselines under different noisy ratios.

Shuang Zhou, Jiashuo Wang, Zidu Xu et al.

Explainable disease diagnosis, which leverages patient information (e.g., signs and symptoms) and computational models to generate probable diagnoses and reasonings, offers clear clinical values. However, when clinical notes encompass insufficient evidence for a definite diagnosis, such as the absence of definitive symptoms, diagnostic uncertainty usually arises, increasing the risk of misdiagnosis and adverse outcomes. Although explicitly identifying and explaining diagnostic uncertainties is essential for trustworthy diagnostic systems, it remains under-explored. To fill this gap, we introduce ConfiDx, an uncertainty-aware large language model (LLM) created by fine-tuning open-source LLMs with diagnostic criteria. We formalized the task and assembled richly annotated datasets that capture varying degrees of diagnostic ambiguity. Evaluating ConfiDx on real-world datasets demonstrated that it excelled in identifying diagnostic uncertainties, achieving superior diagnostic performance, and generating trustworthy explanations for diagnoses and uncertainties. To our knowledge, this is the first study to jointly address diagnostic uncertainty recognition and explanation, substantially enhancing the reliability of automatic diagnostic systems.

Zaifu Zhan, Jun Wang, Shuang Zhou et al.

Objective: To optimize in-context learning in biomedical natural language processing by improving example selection. Methods: We introduce a novel multi-mode retrieval-augmented generation (MMRAG) framework, which integrates four retrieval strategies: (1) Random Mode, selecting examples arbitrarily; (2) Top Mode, retrieving the most relevant examples based on similarity; (3) Diversity Mode, ensuring variation in selected examples; and (4) Class Mode, selecting category-representative examples. This study evaluates MMRAG on three core biomedical NLP tasks: Named Entity Recognition (NER), Relation Extraction (RE), and Text Classification (TC). The datasets used include BC2GM for gene and protein mention recognition (NER), DDI for drug-drug interaction extraction (RE), GIT for general biomedical information extraction (RE), and HealthAdvice for health-related text classification (TC). The framework is tested with two large language models (Llama2-7B, Llama3-8B) and three retrievers (Contriever, MedCPT, BGE-Large) to assess performance across different retrieval strategies. Results: The results from the Random mode indicate that providing more examples in the prompt improves the model's generation performance. Meanwhile, Top mode and Diversity mode significantly outperform Random mode on the RE (DDI) task, achieving an F1 score of 0.9669, a 26.4% improvement. Among the three retrievers tested, Contriever outperformed the other two in a greater number of experiments. Additionally, Llama 2 and Llama 3 demonstrated varying capabilities across different tasks, with Llama 3 showing a clear advantage in handling NER tasks. Conclusion: MMRAG effectively enhances biomedical in-context learning by refining example selection, mitigating data scarcity issues, and demonstrating superior adaptability for NLP-driven healthcare applications.

Zaifu Zhan, Shuang Zhou, Xiaoshan Zhou et al.

Objectives: We aim to dynamically retrieve informative demonstrations, enhancing in-context learning in multimodal large language models (MLLMs) for disease classification. Methods: We propose a Retrieval-Augmented In-Context Learning (RAICL) framework, which integrates retrieval-augmented generation (RAG) and in-context learning (ICL) to adaptively select demonstrations with similar disease patterns, enabling more effective ICL in MLLMs. Specifically, RAICL examines embeddings from diverse encoders, including ResNet, BERT, BioBERT, and ClinicalBERT, to retrieve appropriate demonstrations, and constructs conversational prompts optimized for ICL. We evaluated the framework on two real-world multi-modal datasets (TCGA and IU Chest X-ray), assessing its performance across multiple MLLMs (Qwen, Llava, Gemma), embedding strategies, similarity metrics, and varying numbers of demonstrations. Results: RAICL consistently improved classification performance. Accuracy increased from 0.7854 to 0.8368 on TCGA and from 0.7924 to 0.8658 on IU Chest X-ray. Multi-modal inputs outperformed single-modal ones, with text-only inputs being stronger than images alone. The richness of information embedded in each modality will determine which embedding model can be used to get better results. Few-shot experiments showed that increasing the number of retrieved examples further enhanced performance. Across different similarity metrics, Euclidean distance achieved the highest accuracy while cosine similarity yielded better macro-F1 scores. RAICL demonstrated consistent improvements across various MLLMs, confirming its robustness and versatility. Conclusions: RAICL provides an efficient and scalable approach to enhance in-context learning in MLLMs for multimodal disease classification.