Pan Du

Pan Du, Mingqi Xu, Xiaozhi Zhu et al.

Accurate characterization of vascular geometry is essential for cardiovascular diagnosis and treatment planning. Traditional statistical shape modeling (SSM) methods rely on linear assumptions, limiting their expressivity and scalability to complex topologies such as multi-branch vascular structures. We introduce HUG-VAS, a Hierarchical NURBS Generative model for Vascular geometry Synthesis, which integrates NURBS surface parameterization with diffusion-based generative modeling to synthesize realistic, fine-grained aortic geometries. Trained with 21 patient-specific samples, HUG-VAS generates anatomically faithful aortas with supra-aortic branches, yielding biomarker distributions that closely match those of the original dataset. HUG-VAS adopts a hierarchical architecture comprising a denoising diffusion model that generates centerlines and a guided diffusion model that synthesizes radial profiles conditioned on those centerlines, thereby capturing two layers of anatomical variability. Critically, the framework supports zero-shot conditional generation from image-derived priors, enabling practical applications such as interactive semi-automatic segmentation, robust reconstruction under degraded imaging conditions, and implantable device optimization. To our knowledge, HUG-VAS is the first SSM framework to bridge image-derived priors with generative shape modeling via a unified integration of NURBS parameterization and hierarchical diffusion processes.

Pan Du, Wangbo Zhao, Xinai Lu et al.

Class distribution mismatch (CDM) refers to the discrepancy between class distributions in training data and target tasks. Previous methods address this by designing classifiers to categorize classes known during training, while grouping unknown or new classes into an "other" category. However, they focus on semi-supervised scenarios and heavily rely on labeled data, limiting their applicability and performance. To address this, we propose Unsupervised Learning for Class Distribution Mismatch (UCDM), which constructs positive-negative pairs from unlabeled data for classifier training. Our approach randomly samples images and uses a diffusion model to add or erase semantic classes, synthesizing diverse training pairs. Additionally, we introduce a confidence-based labeling mechanism that iteratively assigns pseudo-labels to valuable real-world data and incorporates them into the training process. Extensive experiments on three datasets demonstrate UCDM's superiority over previous semi-supervised methods. Specifically, with a 60% mismatch proportion on Tiny-ImageNet dataset, our approach, without relying on labeled data, surpasses OpenMatch (with 40 labels per class) by 35.1%, 63.7%, and 72.5% in classifying known, unknown, and new classes.