Xingguang Wang

Ziqi Yang, Zhongyu Li, Chen Liu et al.

Convolutional neural networks excel in histopathological image classification, yet their pixel-level focus hampers explainability. Conversely, emerging graph convolutional networks spotlight cell-level features and medical implications. However, limited by their shallowness and suboptimal use of high-dimensional pixel data, GCNs underperform in multi-class histopathological image classification. To make full use of pixel-level and cell-level features dynamically, we propose an asymmetric co-training framework combining a deep graph convolutional network and a convolutional neural network for multi-class histopathological image classification. To improve the explainability of the entire framework by embedding morphological and topological distribution of cells, we build a 14-layer deep graph convolutional network to handle cell graph data. For the further utilization and dynamic interactions between pixel-level and cell-level information, we also design a co-training strategy to integrate the two asymmetric branches. Notably, we collect a private clinically acquired dataset termed LUAD7C, including seven subtypes of lung adenocarcinoma, which is rare and more challenging. We evaluated our approach on the private LUAD7C and public colorectal cancer datasets, showcasing its superior performance, explainability, and generalizability in multi-class histopathological image classification.

Senhao Wang, Chenghao Cai, Haitao Hu et al.

Reinforcement learning (RL) has achieved strong results in improving large language models (LLMs) on tasks with stationary, verifiable rewards, such as mathematical reasoning and code execution. In these settings, the environment follows fixed rules and does not adapt strategically to the agent. Strategic dialogue differs in this respect: the environment is another agent that adapts to the policy, and success depends on the interaction between the two sides. Despite this interactive nature, current RL approaches typically train a target agent against a fixed counterpart or simulator. We find that this training paradigm encourages the policy to exploit counterpart-specific regularities rather than learn strategies that generalize across counterparts. We call this problem the static-counterpart mismatch, which we quantify directly in our experiments. To address it, we propose Isolated Bilateral Reinforcement Learning (IB-RL), in which the two roles coevolve through joint rollouts while each role optimizes its own reward through fully independent advantages, action masks, and update paths. We evaluate frozen policies against fully independent held-out counterparts in both domains. On Vehicle TeleSales, IB-RL achieves 89.6% Success@1, compared to 84.6% for the best unilateral RL baseline. On Deal-or-NoDeal, it reaches 98.4% agreement against DeepSeek V4 Pro, compared to 86.4% for the best unilateral baseline. These results indicate that jointly training both roles with strict peragent isolation produces policies that generalize more effectively to unseen counterparts.