Rui‐Sheng Wang

Harto Saarinen, Mark Goldsmith, Rui-Sheng Wang et al.

Disease gene prioritization assigns scores to genes or proteins according to their likely relevance for a given disease based on a provided set of seed genes. Here, we describe a new algorithm for disease gene prioritization based on continuous-time quantum walks using the adjacency matrix of a protein-protein interaction (PPI) network. Our algorithm can be seen as a quantum version of a previous method known as the diffusion kernel, but, importantly, has higher performance in predicting disease genes, and also permits the encoding of seed node self-loops into the underlying Hamiltonian, which offers yet another boost in performance. We demonstrate the success of our proposed method by comparing it to several well-known gene prioritization methods on three disease sets, across seven different PPI networks. In order to compare these methods, we use cross-validation and examine the mean reciprocal ranks and recall values. We further validate our method by performing an enrichment analysis of the predicted genes for coronary artery disease. We also investigate the impact of adding self-loops to the seeds, and argue that they allow the quantum walker to remain more local to low-degree seed nodes.

Rongtao Xu, Jinzhou Lin, Jialei Zhou et al.

Camera-based occupancy prediction is a mainstream approach for 3D perception in autonomous driving, aiming to infer complete 3D scene geometry and semantics from 2D images. Almost existing methods focus on improving performance through structural modifications, such as lightweight backbones and complex cascaded frameworks, with good yet limited performance. Few studies explore from the perspective of representation fusion, leaving the rich diversity of features in 2D images underutilized. Motivated by this, we propose \textbf{CIGOcc, a two-stage occupancy prediction framework based on multi-level representation fusion. \textbf{CIGOcc extracts segmentation, graphics, and depth features from an input image and introduces a deformable multi-level fusion mechanism to fuse these three multi-level features. Additionally, CIGOcc incorporates knowledge distilled from SAM to further enhance prediction accuracy. Without increasing training costs, CIGOcc achieves state-of-the-art performance on the SemanticKITTI benchmark. The code is provided in the supplementary material and will be released https://github.com/VitaLemonTea1/CIGOcc