Ning Ding

Tianyu Yu, Zefan Wang, Chongyi Wang et al. · tsinghua

Multimodal Large Language Models (MLLMs) are undergoing rapid progress and represent the frontier of AI development. However, their training and inference efficiency have emerged as a core bottleneck in making MLLMs more accessible and scalable. To address the challenges, we present MiniCPM-V 4.5, an 8B parameter model designed for high efficiency and strong performance. We introduce three core improvements in model architecture, data strategy and training method: a unified 3D-Resampler model architecture for highly compact encoding over images and videos, a unified learning paradigm for document knowledge and text recognition without heavy data engineering, and a hybrid reinforcement learning strategy for proficiency in both short and long reasoning modes. Comprehensive experimental results in OpenCompass evaluation show that MiniCPM-V 4.5 surpasses widely used proprietary models such as GPT-4o-latest, and significantly larger open-source models such as Qwen2.5-VL 72B. Notably, the strong performance is achieved with remarkable efficiency. For example, on the widely adopted VideoMME benchmark, MiniCPM-V 4.5 achieves state-of-the-art performance among models under 30B size, using just 46.7\% GPU memory cost and 8.7\% inference time of Qwen2.5-VL 7B.

Yongqi Tian, Xueyu Sun, Haoyuan He et al.

Hand-object interaction(HOI) is the fundamental link between human and environment, yet its dexterous and complex pose significantly challenges for gesture control. Despite significant advances in AI and robotics, enabling machines to understand and simulate hand-object interactions, capturing the semantics of functional grasping tasks remains a considerable challenge. While previous work can generate stable and correct 3D grasps, they are still far from achieving functional grasps due to unconsidered grasp semantics. To address this challenge, we propose an innovative two-stage framework, Functional Grasp Synthesis Net (FGS-Net), for generating 3D HOI driven by functional text. This framework consists of a text-guided 3D model generator, Functional Grasp Generator (FGG), and a pose optimization strategy, Functional Grasp Refiner (FGR). FGG generates 3D models of hands and objects based on text input, while FGR fine-tunes the poses using Object Pose Approximator and energy functions to ensure the relative position between the hand and object aligns with human intent and remains physically plausible. Extensive experiments demonstrate that our approach achieves precise and high-quality HOI generation without requiring additional 3D annotation data.

Yuhan Chen, Shang Qu, Zhiqiang Gao et al.

Post-translational modifications (PTMs) serve as a dynamic chemical language regulating protein function, yet current proteomic methods remain blind to a vast portion of the modified proteome. Standard database search algorithms suffer from a combinatorial explosion of search spaces, limiting the identification of uncharacterized or complex modifications. Here we introduce OmniNovo, a unified deep learning framework for reference-free sequencing of unmodified and modified peptides directly from tandem mass spectra. Unlike existing tools restricted to specific modification types, OmniNovo learns universal fragmentation rules to decipher diverse PTMs within a single coherent model. By integrating a mass-constrained decoding algorithm with rigorous false discovery rate estimation, OmniNovo achieves state-of-the-art accuracy, identifying 51\% more peptides than standard approaches at a 1\% false discovery rate. Crucially, the model generalizes to biological sites unseen during training, illuminating the dark matter of the proteome and enabling unbiased comprehensive analysis of cellular regulation.