Naomi Sagan

Erica Zhang, Naomi Sagan, Danny Tse et al.

We introduce Statsformer, a principled framework for integrating large language model (LLM)-derived knowledge into supervised statistical learning. Existing approaches are limited in adaptability and scope: they either inject LLM guidance as an unvalidated heuristic, which is sensitive to LLM hallucination, or embed semantic information within a single fixed learner. Statsformer overcomes both limitations through a guardrailed ensemble architecture. We embed LLM-derived feature priors within an ensemble of linear and nonlinear learners, adaptively calibrating their influence via cross-validation. This design yields a flexible system with an oracle-style guarantee that it performs no worse than any convex combination of its in-library base learners, up to statistical error. Empirically, informative priors yield consistent performance improvements, while uninformative or misspecified LLM guidance is automatically downweighted, mitigating the impact of hallucinations across a diverse range of prediction tasks.An open-source implementation of Statsformer is available at https://github.com/pilancilab/statsformer.

Erica Zhang, Ryunosuke Goto, Naomi Sagan et al.

We introduce LLM-Lasso, a novel framework that leverages large language models (LLMs) to guide feature selection in Lasso $\ell_1$ regression. Unlike traditional methods that rely solely on numerical data, LLM-Lasso incorporates domain-specific knowledge extracted from natural language, enhanced through a retrieval-augmented generation (RAG) pipeline, to seamlessly integrate data-driven modeling with contextual insights. Specifically, the LLM generates penalty factors for each feature, which are converted into weights for the Lasso penalty using a simple, tunable model. Features identified as more relevant by the LLM receive lower penalties, increasing their likelihood of being retained in the final model, while less relevant features are assigned higher penalties, reducing their influence. Importantly, LLM-Lasso has an internal validation step that determines how much to trust the contextual knowledge in our prediction pipeline. Hence it addresses key challenges in robustness, making it suitable for mitigating potential inaccuracies or hallucinations from the LLM. In various biomedical case studies, LLM-Lasso outperforms standard Lasso and existing feature selection baselines, all while ensuring the LLM operates without prior access to the datasets. To our knowledge, this is the first approach to effectively integrate conventional feature selection techniques directly with LLM-based domain-specific reasoning.

Atindra Jha, Naomi Sagan, Keisuke Kamahori et al.

We are entering a new era of composite model architectures that integrate diverse components such as vision encoders, language backbones, diffusion and flow heads, audio codecs, action generators, and world-model predictors. Such architectures underpin a broad class of multimodal models, including unified multimodal models, omni models, speech-language models, vision-language-action policies, and world models. However, existing model serving frameworks were built on narrow assumptions about model structure, making them ill-suited to accommodate this new architectural diversity. Here we present M*, a universal serving system for efficient serving of composite AI models. M* represents models as dataflow graphs, processing requests spanning diverse modalities and tasks as traversals over these graphs. The core insight is a modular abstraction that supports arbitrary composition of model components, flexible placement onto a physical cluster, and model-agnostic optimizations within a distributed runtime. We call this abstraction the Walk Graph and show how it can concisely capture composite models from a broad range of families. We instantiate M* on representative models and find that it achieves, on average, 20% lower end-to-end latency than vLLM-Omni for text-to-image workloads on BAGEL, while delivering up to 2.9x lower real-time factor and 2.7x higher throughput for text-to-speech workloads on Qwen3-Omni. M* also outperforms the V-JEPA 2-AC rollout baseline for robotic planning by up to 12.5x. Thus, our work paves the road towards more efficient serving of complex models with minimal developer effort.