Anthony Magliari

Riqiang Gao, Mamadou Diallo, Han Liu et al.

Radiotherapy (RT) planning is complex, subjective, and time-intensive. Advances with artificial intelligence (AI) promise to improve its precision and efficiency, but progress is often limited by the scarcity of large, standardized datasets. To address this, we introduce the Automated Iterative RT Planning (AIRTP) system, a scalable solution for generating high-quality treatment plans. This scalable solution is designed to generate substantial volumes of consistently high-quality treatment plans, overcoming a key obstacle in the advancement of AI-driven RT planning. Our AIRTP pipeline adheres to clinical guidelines and automates essential steps, including organ-at-risk (OAR) contouring, helper structure creation, beam setup, optimization, and plan quality improvement, using AI integrated with RT planning software like Varian Eclipse. Furthermore, a novel approach for determining optimization parameters to reproduce 3D dose distributions, i.e. a method to convert dose predictions to deliverable treatment plans constrained by machine limitations is proposed. A comparative analysis of plan quality reveals that our automated pipeline produces treatment plans of quality comparable to those generated manually, which traditionally require several hours of labor per plan. Committed to public research, the first data release of our AIRTP pipeline includes nine cohorts covering head-and-neck and lung cancer sites to support an AAPM 2025 challenge. To our best knowledge, this dataset features more than 10 times number of plans compared to the largest existing well-curated public dataset. Repo: https://github.com/RiqiangGao/GDP-HMM_AAPMChallenge.

Japan K. Patel, Barry D. Ganapol, Anthony Magliari et al.

This work extends our one-dimensional single-sweep neural-operator studies to two dimensions. We consider one-group transport with isotropic scattering. As in the one-dimensional work, we use Fourier neural operators (FNOs) to approximate the high-fidelity scalar flux. Additionally, we also investigate U-shaped neural operators (UNOs) in this study. We consider three surrogates. The first two map the material and source fields directly to the flux, one using an FNO and one using a UNO. The third is an FNO that additionally takes the scalar flux after one source iteration, the single-sweep approximation, as an input. Each case is solved to high fidelity with a verified discrete-ordinates solver, and an average relative L_2 error norm is used to characterize the quality of the inferred maps. We train every surrogate over three random seeds so that differences between them can be assessed against run-to-run variability. Two questions guide the study: whether the single-sweep input improves accuracy over the direct maps, and whether training on the logarithm of the flux improves accuracy in the strongly attenuated regions relevant to shielding.

Simon Arberet, Riqiang Gao, Martin Kraus et al.

Artificial intelligence-based radiation therapy (RT) planning has the potential to reduce planning time and inter-planner variability, improving efficiency and consistency in clinical workflows. Most existing automated approaches rely on multiple dose evaluations and corrections, resulting in plan generation times of several minutes. We introduce AIRT (Artificial Intelligence-based Radiotherapy), an end-to-end deep-learning framework that directly infers deliverable treatment plans from CT images and structure contours. AIRT generates single-arc VMAT prostate plans, from imaging and anatomical inputs to leaf sequencing, in under one second on a single Nvidia A100 GPU. The framework includes a differentiable dose feedback, an adversarial fluence map shaping, and a plan generation augmentation to improve plan quality and robustness. The model was trained on more than 10,000 intact prostate cases. Non-inferiority to RapidPlan Eclipse was demonstrated across target coverage and OAR sparing metrics. Target homogeneity (HI = 0.10 $\pm$ 0.01) and OAR sparing were similar to reference plans when evaluated using AcurosXB. These results represent a significant step toward ultra-fast standardized RT planning and a streamlined clinical workflow.