Toward Robust Early Detection of Alzheimer's Disease via an Integrated Multimodal Learning ApproachYifei Chen, Shenghao Zhu, Zhaojie Fang et al.
Alzheimer's Disease (AD) is a complex neurodegenerative disorder marked by memory loss, executive dysfunction, and personality changes. Early diagnosis is challenging due to subtle symptoms and varied presentations, often leading to misdiagnosis with traditional unimodal diagnostic methods due to their limited scope. This study introduces an advanced multimodal classification model that integrates clinical, cognitive, neuroimaging, and EEG data to enhance diagnostic accuracy. The model incorporates a feature tagger with a tabular data coding architecture and utilizes the TimesBlock module to capture intricate temporal patterns in Electroencephalograms (EEG) data. By employing Cross-modal Attention Aggregation module, the model effectively fuses Magnetic Resonance Imaging (MRI) spatial information with EEG temporal data, significantly improving the distinction between AD, Mild Cognitive Impairment, and Normal Cognition. Simultaneously, we have constructed the first AD classification dataset that includes three modalities: EEG, MRI, and tabular data. Our innovative approach aims to facilitate early diagnosis and intervention, potentially slowing the progression of AD. The source code and our private ADMC dataset are available at https://github.com/JustlfC03/MSTNet.
ECACL: A Holistic Framework for Semi-Supervised Domain AdaptationKai Li, Chang Liu, Handong Zhao et al.
This paper studies Semi-Supervised Domain Adaptation (SSDA), a practical yet under-investigated research topic that aims to learn a model of good performance using unlabeled samples and a few labeled samples in the target domain, with the help of labeled samples from a source domain. Several SSDA methods have been proposed recently, which however fail to fully exploit the value of the few labeled target samples. In this paper, we propose Enhanced Categorical Alignment and Consistency Learning (ECACL), a holistic SSDA framework that incorporates multiple mutually complementary domain alignment techniques. ECACL includes two categorical domain alignment techniques that achieve class-level alignment, a strong data augmentation based technique that enhances the model's generalizability and a consistency learning based technique that forces the model to be robust with image perturbations. These techniques are applied on one or multiple of the three inputs (labeled source, unlabeled target, and labeled target) and align the domains from different perspectives. ECACL unifies them together and achieves fairly comprehensive domain alignments that are much better than the existing methods: For example, ECACL raises the state-of-the-art accuracy from 68.4 to 81.1 on VisDA2017 and from 45.5 to 53.4 on DomainNet for the 1-shot setting. Our code is available at \url{https://github.com/kailigo/pacl}.
21.3AIJun 30, 2025
A Survey on Autonomy-Induced Security Risks in Large Model-Based AgentsHang Su, Jun Luo, Chang Liu et al.
Recent advances in large language models (LLMs) have catalyzed the rise of autonomous AI agents capable of perceiving, reasoning, and acting in dynamic, open-ended environments. These large-model agents mark a paradigm shift from static inference systems to interactive, memory-augmented entities. While these capabilities significantly expand the functional scope of AI, they also introduce qualitatively novel security risks - such as memory poisoning, tool misuse, reward hacking, and emergent misalignment - that extend beyond the threat models of conventional systems or standalone LLMs. In this survey, we first examine the structural foundations and key capabilities that underpin increasing levels of agent autonomy, including long-term memory retention, modular tool use, recursive planning, and reflective reasoning. We then analyze the corresponding security vulnerabilities across the agent stack, identifying failure modes such as deferred decision hazards, irreversible tool chains, and deceptive behaviors arising from internal state drift or value misalignment. These risks are traced to architectural fragilities that emerge across perception, cognition, memory, and action modules. To address these challenges, we systematically review recent defense strategies deployed at different autonomy layers, including input sanitization, memory lifecycle control, constrained decision-making, structured tool invocation, and introspective reflection. We introduce the Reflective Risk-Aware Agent Architecture (R2A2), a unified cognitive framework grounded in Constrained Markov Decision Processes (CMDPs), which incorporates risk-aware world modeling, meta-policy adaptation, and joint reward-risk optimization to enable principled, proactive safety across the agent's decision-making loop.