Bo Li

Boyu Chen, Peixia Li, Lei Bai et al.

Exploiting a general-purpose neural architecture to replace hand-wired designs or inductive biases has recently drawn extensive interest. However, existing tracking approaches rely on customized sub-modules and need prior knowledge for architecture selection, hindering the tracking development in a more general system. This paper presents a Simplified Tracking architecture (SimTrack) by leveraging a transformer backbone for joint feature extraction and interaction. Unlike existing Siamese trackers, we serialize the input images and concatenate them directly before the one-branch backbone. Feature interaction in the backbone helps to remove well-designed interaction modules and produce a more efficient and effective framework. To reduce the information loss from down-sampling in vision transformers, we further propose a foveal window strategy, providing more diverse input patches with acceptable computational costs. Our SimTrack improves the baseline with 2.5%/2.6% AUC gains on LaSOT/TNL2K and gets results competitive with other specialized tracking algorithms without bells and whistles.

Qiulin Wang, Lu Zhang, Bo Li

Recent success of generative adversarial networks (GAN) has made great progress on the face animation task. However, the complex scene structure of a face image still makes it a challenge to generate videos with face poses significantly deviating from the source image. On one hand, without knowing the facial geometric structure, generated face images might be improperly distorted. On the other hand, some area of the generated image might be occluded in the source image, which makes it difficult for GAN to generate realistic appearance. To address these problems, we propose a structure aware face animation (SAFA) method which constructs specific geometric structures to model different components of a face image. Following the well recognized motion based face animation technique, we use a 3D morphable model (3DMM) to model the face, multiple affine transforms to model the other foreground components like hair and beard, and an identity transform to model the background. The 3DMM geometric embedding not only helps generate realistic structure for the driving scene, but also contributes to better perception of occluded area in the generated image. Besides, we further propose to exploit the widely studied inpainting technique to faithfully recover the occluded image area. Both quantitative and qualitative experiment results have shown the superiority of our method. Code is available at https://github.com/Qiulin-W/SAFA.

Bo Li, Bob Zhang, Chengyang Zhang et al.

In the field of image-based drug discovery, capturing the phenotypic response of cells to various drug treatments and perturbations is a crucial step. However, existing methods require computationally extensive and complex multi-step procedures, which can introduce inefficiencies, limit generalizability, and increase potential errors. To address these challenges, we present PhenoProfiler, an innovative model designed to efficiently and effectively extract morphological representations, enabling the elucidation of phenotypic changes induced by treatments. PhenoProfiler is designed as an end-to-end tool that processes whole-slide multi-channel images directly into low-dimensional quantitative representations, eliminating the extensive computational steps required by existing methods. It also includes a multi-objective learning module to enhance robustness, accuracy, and generalization in morphological representation learning. PhenoProfiler is rigorously evaluated on large-scale publicly available datasets, including over 230,000 whole-slide multi-channel images in end-to-end scenarios and more than 8.42 million single-cell images in non-end-to-end settings. Across these benchmarks, PhenoProfiler consistently outperforms state-of-the-art methods by up to 20%, demonstrating substantial improvements in both accuracy and robustness. Furthermore, PhenoProfiler uses a tailored phenotype correction strategy to emphasize relative phenotypic changes under treatments, facilitating the detection of biologically meaningful signals. UMAP visualizations of treatment profiles demonstrate PhenoProfiler ability to effectively cluster treatments with similar biological annotations, thereby enhancing interpretability. These findings establish PhenoProfiler as a scalable, generalizable, and robust tool for phenotypic learning.