Yi Zhang

Tianshu Zheng, Cong Sun, Weihao Zheng et al.

Diffusion magnetic resonance imaging (dMRI) is an important tool in characterizing tissue microstructure based on biophysical models, which are complex and highly non-linear. Resolving microstructures with optimization techniques is prone to estimation errors and requires dense sampling in the q-space. Deep learning based approaches have been proposed to overcome these limitations. Motivated by the superior performance of the Transformer, in this work, we present a learning-based framework based on Transformer, namely, a Microstructure Estimation Transformer with Sparse Coding (METSC) for dMRI-based microstructure estimation with downsampled q-space data. To take advantage of the Transformer while addressing its limitation in large training data requirements, we explicitly introduce an inductive bias - model bias into the Transformer using a sparse coding technique to facilitate the training process. Thus, the METSC is composed with three stages, an embedding stage, a sparse representation stage, and a mapping stage. The embedding stage is a Transformer-based structure that encodes the signal to ensure the voxel is represented effectively. In the sparse representation stage, a dictionary is constructed by solving a sparse reconstruction problem that unfolds the Iterative Hard Thresholding (IHT) process. The mapping stage is essentially a decoder that computes the microstructural parameters from the output of the second stage, based on the weighted sum of normalized dictionary coefficients where the weights are also learned. We tested our framework on two dMRI models with downsampled q-space data, including the intravoxel incoherent motion (IVIM) model and the neurite orientation dispersion and density imaging (NODDI) model. The proposed method achieved up to 11.25 folds of acceleration in scan time and outperformed the other state-of-the-art learning-based methods.

Yiqun Chen, Lingyong Yan, Weiwei Sun et al.

Retrieval-augmented generation (RAG) is widely utilized to incorporate external knowledge into large language models, thereby enhancing factuality and reducing hallucinations in question-answering (QA) tasks. A standard RAG pipeline consists of several components, such as query rewriting, document retrieval, document filtering, and answer generation. However, these components are typically optimized separately through supervised fine-tuning, which can lead to misalignments between the objectives of individual components and the overarching aim of generating accurate answers. Although recent efforts have explored using reinforcement learning (RL) to optimize specific RAG components, these approaches often focus on simple pipelines with only two components or do not adequately address the complex interdependencies and collaborative interactions among the modules. To overcome these limitations, we propose treating the complex RAG pipeline with multiple components as a multi-agent cooperative task, in which each component can be regarded as an RL agent. Specifically, we present MMOA-RAG, Multi-Module joint Optimization Algorithm for RAG, which employs multi-agent reinforcement learning to harmonize all agents' goals toward a unified reward, such as the F1 score of the final answer. Experiments conducted on various QA benchmarks demonstrate that MMOA-RAG effectively boost the overall performance of the pipeline and outperforms existing baselines. Furthermore, comprehensive ablation studies validate the contributions of individual components and demonstrate MMOA-RAG can be adapted to different RAG pipelines and benchmarks.