Yue Wu

CV
h-index20
21papers
1,179citations
Novelty47%
AI Score50

21 Papers

42.8CVMay 30, 2022Code
Prompt-aligned Gradient for Prompt Tuning

Beier Zhu, Yulei Niu, Yucheng Han et al.

Thanks to the large pre-trained vision-language models (VLMs) like CLIP, we can craft a zero-shot classifier by "prompt", e.g., the confidence score of an image being "[CLASS]" can be obtained by using the VLM provided similarity measure between the image and the prompt sentence "a photo of a [CLASS]". Therefore, prompt shows a great potential for fast adaptation of VLMs to downstream tasks if we fine-tune the prompt-based similarity measure. However, we find a common failure that improper fine-tuning may not only undermine the prompt's inherent prediction for the task-related classes, but also for other classes in the VLM vocabulary. Existing methods still address this problem by using traditional anti-overfitting techniques such as early stopping and data augmentation, which lack a principled solution specific to prompt. We present Prompt-aligned Gradient, dubbed ProGrad, to prevent prompt tuning from forgetting the the general knowledge learned from VLMs. In particular, ProGrad only updates the prompt whose gradient is aligned (or non-conflicting) to the "general direction", which is represented as the gradient of the KL loss of the pre-defined prompt prediction. Extensive experiments demonstrate the stronger few-shot generalization ability of ProGrad over state-of-the-art prompt tuning methods. Codes are available at https://github.com/BeierZhu/Prompt-align.

21.0LGDec 2, 2022Code
Avoiding spurious correlations via logit correction

Sheng Liu, Xu Zhang, Nitesh Sekhar et al. · amazon-science

Empirical studies suggest that machine learning models trained with empirical risk minimization (ERM) often rely on attributes that may be spuriously correlated with the class labels. Such models typically lead to poor performance during inference for data lacking such correlations. In this work, we explicitly consider a situation where potential spurious correlations are present in the majority of training data. In contrast with existing approaches, which use the ERM model outputs to detect the samples without spurious correlations and either heuristically upweight or upsample those samples, we propose the logit correction (LC) loss, a simple yet effective improvement on the softmax cross-entropy loss, to correct the sample logit. We demonstrate that minimizing the LC loss is equivalent to maximizing the group-balanced accuracy, so the proposed LC could mitigate the negative impacts of spurious correlations. Our extensive experimental results further reveal that the proposed LC loss outperforms state-of-the-art solutions on multiple popular benchmarks by a large margin, an average 5.5\% absolute improvement, without access to spurious attribute labels. LC is also competitive with oracle methods that make use of the attribute labels. Code is available at https://github.com/shengliu66/LC.

12.1CVJun 15, 2023
Exploring the Application of Large-scale Pre-trained Models on Adverse Weather Removal

Zhentao Tan, Yue Wu, Qiankun Liu et al.

Image restoration under adverse weather conditions (e.g., rain, snow and haze) is a fundamental computer vision problem and has important indications for various downstream applications. Different from early methods that are specially designed for specific type of weather, most recent works tend to remove various adverse weather effects simultaneously through either spatial feature representation learning or semantic information embedding. Inspired by the various successful applications of large-scale pre-trained models (e.g, CLIP), in this paper, we explore the potential benefits of them for this task through both spatial feature representation learning and semantic information embedding aspects: 1) for spatial feature representation learning, we design a Spatially-Adaptive Residual (\textbf{SAR}) Encoder to extract degraded areas adaptively. To facilitate its training, we propose a Soft Residual Distillation (\textbf{CLIP-SRD}) strategy to transfer the spatial knowledge from CLIP between clean and adverse weather images; 2) for semantic information embedding, we propose a CLIP Weather Prior (\textbf{CWP}) embedding module to make the network handle different weather conditions adaptively. This module integrates the sample specific weather prior extracted by CLIP image encoder together with the distribution specific information learned by a set of parameters, and embeds them through a cross attention mechanism. Extensive experiments demonstrate that our proposed method can achieve state-of-the-art performance under different and challenging adverse weather conditions. Code will be made available.

9.6LGJul 10, 2022Code
Graph Generative Model for Benchmarking Graph Neural Networks

Minji Yoon, Yue Wu, John Palowitch et al.

As the field of Graph Neural Networks (GNN) continues to grow, it experiences a corresponding increase in the need for large, real-world datasets to train and test new GNN models on challenging, realistic problems. Unfortunately, such graph datasets are often generated from online, highly privacy-restricted ecosystems, which makes research and development on these datasets hard, if not impossible. This greatly reduces the amount of benchmark graphs available to researchers, causing the field to rely only on a handful of publicly-available datasets. To address this problem, we introduce a novel graph generative model, Computation Graph Transformer (CGT) that learns and reproduces the distribution of real-world graphs in a privacy-controlled way. More specifically, CGT (1) generates effective benchmark graphs on which GNNs show similar task performance as on the source graphs, (2) scales to process large-scale graphs, (3) incorporates off-the-shelf privacy modules to guarantee end-user privacy of the generated graph. Extensive experiments across a vast body of graph generative models show that only our model can successfully generate privacy-controlled, synthetic substitutes of large-scale real-world graphs that can be effectively used to benchmark GNN models.

18.2CVJun 27, 2022Code
Optimizing Video Prediction via Video Frame Interpolation

Yue Wu, Qiang Wen, Qifeng Chen

Video prediction is an extrapolation task that predicts future frames given past frames, and video frame interpolation is an interpolation task that estimates intermediate frames between two frames. We have witnessed the tremendous advancement of video frame interpolation, but the general video prediction in the wild is still an open question. Inspired by the photo-realistic results of video frame interpolation, we present a new optimization framework for video prediction via video frame interpolation, in which we solve an extrapolation problem based on an interpolation model. Our video prediction framework is based on optimization with a pretrained differentiable video frame interpolation module without the need for a training dataset, and thus there is no domain gap issue between training and test data. Also, our approach does not need any additional information such as semantic or instance maps, which makes our framework applicable to any video. Extensive experiments on the Cityscapes, KITTI, DAVIS, Middlebury, and Vimeo90K datasets show that our video prediction results are robust in general scenarios, and our approach outperforms other video prediction methods that require a large amount of training data or extra semantic information.

22.5CVOct 12, 2022Code
AniFaceGAN: Animatable 3D-Aware Face Image Generation for Video Avatars

Yue Wu, Yu Deng, Jiaolong Yang et al.

Although 2D generative models have made great progress in face image generation and animation, they often suffer from undesirable artifacts such as 3D inconsistency when rendering images from different camera viewpoints. This prevents them from synthesizing video animations indistinguishable from real ones. Recently, 3D-aware GANs extend 2D GANs for explicit disentanglement of camera pose by leveraging 3D scene representations. These methods can well preserve the 3D consistency of the generated images across different views, yet they cannot achieve fine-grained control over other attributes, among which facial expression control is arguably the most useful and desirable for face animation. In this paper, we propose an animatable 3D-aware GAN for multiview consistent face animation generation. The key idea is to decompose the 3D representation of the 3D-aware GAN into a template field and a deformation field, where the former represents different identities with a canonical expression, and the latter characterizes expression variations of each identity. To achieve meaningful control over facial expressions via deformation, we propose a 3D-level imitative learning scheme between the generator and a parametric 3D face model during adversarial training of the 3D-aware GAN. This helps our method achieve high-quality animatable face image generation with strong visual 3D consistency, even though trained with only unstructured 2D images. Extensive experiments demonstrate our superior performance over prior works. Project page: https://yuewuhkust.github.io/AniFaceGAN

26.7CLJun 19, 2023Code
Preserving Commonsense Knowledge from Pre-trained Language Models via Causal Inference

Junhao Zheng, Qianli Ma, Shengjie Qiu et al.

Fine-tuning has been proven to be a simple and effective technique to transfer the learned knowledge of Pre-trained Language Models (PLMs) to downstream tasks. However, vanilla fine-tuning easily overfits the target data and degrades the generalization ability. Most existing studies attribute it to catastrophic forgetting, and they retain the pre-trained knowledge indiscriminately without identifying what knowledge is transferable. Motivated by this, we frame fine-tuning into a causal graph and discover that the crux of catastrophic forgetting lies in the missing causal effects from the pretrained data. Based on the causal view, we propose a unified objective for fine-tuning to retrieve the causality back. Intriguingly, the unified objective can be seen as the sum of the vanilla fine-tuning objective, which learns new knowledge from target data, and the causal objective, which preserves old knowledge from PLMs. Therefore, our method is flexible and can mitigate negative transfer while preserving knowledge. Since endowing models with commonsense is a long-standing challenge, we implement our method on commonsense QA with a proposed heuristic estimation to verify its effectiveness. In the experiments, our method outperforms state-of-the-art fine-tuning methods on all six commonsense QA datasets and can be implemented as a plug-in module to inflate the performance of existing QA models.

9.1CVFeb 12, 2023
Video Waterdrop Removal via Spatio-Temporal Fusion in Driving Scenes

Qiang Wen, Yue Wu, Qifeng Chen

The waterdrops on windshields during driving can cause severe visual obstructions, which may lead to car accidents. Meanwhile, the waterdrops can also degrade the performance of a computer vision system in autonomous driving. To address these issues, we propose an attention-based framework that fuses the spatio-temporal representations from multiple frames to restore visual information occluded by waterdrops. Due to the lack of training data for video waterdrop removal, we propose a large-scale synthetic dataset with simulated waterdrops in complex driving scenes on rainy days. To improve the generality of our proposed method, we adopt a cross-modality training strategy that combines synthetic videos and real-world images. Extensive experiments show that our proposed method can generalize well and achieve the best waterdrop removal performance in complex real-world driving scenes.

5.3LGMar 19, 2023
Elastic Interaction Energy-Based Generative Model: Approximation in Feature Space

Chuqi Chen, Yue Wu, Yang Xiang

In this paper, we propose a novel approach to generative modeling using a loss function based on elastic interaction energy (EIE), which is inspired by the elastic interaction between defects in crystals. The utilization of the EIE-based metric presents several advantages, including its long range property that enables consideration of global information in the distribution. Moreover, its inclusion of a self-interaction term helps to prevent mode collapse and captures all modes of distribution. To overcome the difficulty of the relatively scattered distribution of high-dimensional data, we first map the data into a latent feature space and approximate the feature distribution instead of the data distribution. We adopt the GAN framework and replace the discriminator with a feature transformation network to map the data into a latent space. We also add a stabilizing term to the loss of the feature transformation network, which effectively addresses the issue of unstable training in GAN-based algorithms. Experimental results on popular datasets, such as MNIST, FashionMNIST, CIFAR-10, and CelebA, demonstrate that our EIEG GAN model can mitigate mode collapse, enhance stability, and improve model performance.

4.2CRNov 17, 2024Code
BackdoorMBTI: A Backdoor Learning Multimodal Benchmark Tool Kit for Backdoor Defense Evaluation

Haiyang Yu, Tian Xie, Jiaping Gui et al.

Over the past few years, the emergence of backdoor attacks has presented significant challenges to deep learning systems, allowing attackers to insert backdoors into neural networks. When data with a trigger is processed by a backdoor model, it can lead to mispredictions targeted by attackers, whereas normal data yields regular results. The scope of backdoor attacks is expanding beyond computer vision and encroaching into areas such as natural language processing and speech recognition. Nevertheless, existing backdoor defense methods are typically tailored to specific data modalities, restricting their application in multimodal contexts. While multimodal learning proves highly applicable in facial recognition, sentiment analysis, action recognition, visual question answering, the security of these models remains a crucial concern. Specifically, there are no existing backdoor benchmarks targeting multimodal applications or related tasks. In order to facilitate the research in multimodal backdoor, we introduce BackdoorMBTI, the first backdoor learning toolkit and benchmark designed for multimodal evaluation across three representative modalities from eleven commonly used datasets. BackdoorMBTI provides a systematic backdoor learning pipeline, encompassing data processing, data poisoning, backdoor training, and evaluation. The generated poison datasets and backdoor models enable detailed evaluation of backdoor defenses. Given the diversity of modalities, BackdoorMBTI facilitates systematic evaluation across different data types. Furthermore, BackdoorMBTI offers a standardized approach to handling practical factors in backdoor learning, such as issues related to data quality and erroneous labels. We anticipate that BackdoorMBTI will expedite future research in backdoor defense methods within a multimodal context. Code is available at https://github.com/SJTUHaiyangYu/BackdoorMBTI.

2.0CVNov 25, 2023
Precision Agriculture: Crop Mapping using Machine Learning and Sentinel-2 Satellite Imagery

Kui Zhao, Siyang Wu, Chang Liu et al.

Food security has grown in significance due to the changing climate and its warming effects. To support the rising demand for agricultural products and to minimize the negative impact of climate change and mass cultivation, precision agriculture has become increasingly important for crop cultivation. This study employs deep learning and pixel-based machine learning methods to accurately segment lavender fields for precision agriculture, utilizing various spectral band combinations extracted from Sentinel-2 satellite imagery. Our fine-tuned final model, a U-Net architecture, can achieve a Dice coefficient of 0.8324. Additionally, our investigation highlights the unexpected efficacy of the pixel-based method and the RGB spectral band combination in this task.

20.4CVOct 16, 2025Code
Knowledge-based Visual Question Answer with Multimodal Processing, Retrieval and Filtering

Yuyang Hong, Jiaqi Gu, Qi Yang et al.

Knowledge-based visual question answering (KB-VQA) requires visual language models (VLMs) to integrate visual understanding with external knowledge retrieval. Although retrieval-augmented generation (RAG) achieves significant advances in this task by combining knowledge-base querying, it still struggles with the quality of multimodal queries and the relevance of retrieved results. To overcome these challenges, we propose a novel three-stage method, termed Wiki-PRF, including Processing, Retrieval and Filtering stages. The processing stage dynamically invokes visual tools to extract precise multimodal information for retrieval. The retrieval stage integrates visual and text features to achieve multimodal knowledge retrieval. The filtering stage performs relevance filtering and concentration on retrieval results. To this end, we introduce a visual language model trained with answer accuracy and format consistency as reward signals via a reinforcement learning manner. This enhances the model's reasoning, tool invocation for accurate queries, and filtering of irrelevant content. Experiments on benchmark datasets (E-VQA and InfoSeek) show significant improvements~(36.0 and 42.8) in answer quality, achieving state-of-the-art performance. Code is available at https://github.com/cqu-student/Wiki-PRF

10.2CVOct 13, 2025Code
ExpVid: A Benchmark for Experiment Video Understanding & Reasoning

Yicheng Xu, Yue Wu, Jiashuo Yu et al.

Multimodal Large Language Models (MLLMs) hold promise for accelerating scientific discovery by interpreting complex experimental procedures. However, their true capabilities are poorly understood, as existing benchmarks neglect the fine-grained and long-horizon nature of authentic laboratory work, especially in wet-lab settings. To bridge this gap, we introduce ExpVid, the first benchmark designed to systematically evaluate MLLMs on scientific experiment videos. Curated from peer-reviewed video publications, ExpVid features a new three-level task hierarchy that mirrors the scientific process: (1) Fine-grained Perception of tools, materials, and actions; (2) Procedural Understanding of step order and completeness; and (3) Scientific Reasoning that connects the full experiment to its published conclusions. Our vision-centric annotation pipeline, combining automated generation with multi-disciplinary expert validation, ensures that tasks require visual grounding. We evaluate 19 leading MLLMs on ExpVid and find that while they excel at coarse-grained recognition, they struggle with disambiguating fine details, tracking state changes over time, and linking experimental procedures to scientific outcomes. Our results reveal a notable performance gap between proprietary and open-source models, particularly in high-order reasoning. ExpVid not only provides a diagnostic tool but also charts a roadmap for developing MLLMs capable of becoming trustworthy partners in scientific experimentation.

11.0CVMay 18, 2023Code
Multi-spectral Class Center Network for Face Manipulation Detection and Localization

Changtao Miao, Qi Chu, Zhentao Tan et al.

As deepfake content proliferates online, advancing face manipulation forensics has become crucial. To combat this emerging threat, previous methods mainly focus on studying how to distinguish authentic and manipulated face images. Although impressive, image-level classification lacks explainability and is limited to specific application scenarios, spurring recent research on pixel-level prediction for face manipulation forensics. However, existing forgery localization methods suffer from exploring frequency-based forgery traces in the localization network. In this paper, we observe that multi-frequency spectrum information is effective for identifying tampered regions. To this end, a novel Multi-Spectral Class Center Network (MSCCNet) is proposed for face manipulation detection and localization. Specifically, we design a Multi-Spectral Class Center (MSCC) module to learn more generalizable and multi-frequency features. Based on the features of different frequency bands, the MSCC module collects multi-spectral class centers and computes pixel-to-class relations. Applying multi-spectral class-level representations suppresses the semantic information of the visual concepts which is insensitive to manipulated regions of forgery images. Furthermore, we propose a Multi-level Features Aggregation (MFA) module to employ more low-level forgery artifacts and structural textures. Meanwhile, we conduct a comprehensive localization benchmark based on pixel-level FF++ and Dolos datasets. Experimental results quantitatively and qualitatively demonstrate the effectiveness and superiority of the proposed MSCCNet. We expect this work to inspire more studies on pixel-level face manipulation localization. The codes are available (https://github.com/miaoct/MSCCNet).

39.6LGFeb 10, 2025
MATH-Perturb: Benchmarking LLMs' Math Reasoning Abilities against Hard Perturbations

Kaixuan Huang, Jiacheng Guo, Zihao Li et al.

Large language models have demonstrated impressive performance on challenging mathematical reasoning tasks, which has triggered the discussion of whether the performance is achieved by true reasoning capability or memorization. To investigate this question, prior work has constructed mathematical benchmarks when questions undergo simple perturbations -- modifications that still preserve the underlying reasoning patterns of the solutions. However, no work has explored hard perturbations, which fundamentally change the nature of the problem so that the original solution steps do not apply. To bridge the gap, we construct MATH-P-Simple and MATH-P-Hard via simple perturbation and hard perturbation, respectively. Each consists of 279 perturbed math problems derived from level-5 (hardest) problems in the MATH dataset (Hendrycksmath et. al., 2021). We observe significant performance drops on MATH-P-Hard across various models, including o1-mini (-16.49%) and gemini-2.0-flash-thinking (-12.9%). We also raise concerns about a novel form of memorization where models blindly apply learned problem-solving skills without assessing their applicability to modified contexts. This issue is amplified when using original problems for in-context learning. We call for research efforts to address this challenge, which is critical for developing more robust and reliable reasoning models.

27.7AIDec 17, 2023Code
A Survey of Reasoning with Foundation Models

Jiankai Sun, Chuanyang Zheng, Enze Xie et al.

Reasoning, a crucial ability for complex problem-solving, plays a pivotal role in various real-world settings such as negotiation, medical diagnosis, and criminal investigation. It serves as a fundamental methodology in the field of Artificial General Intelligence (AGI). With the ongoing development of foundation models, e.g., Large Language Models (LLMs), there is a growing interest in exploring their abilities in reasoning tasks. In this paper, we introduce seminal foundation models proposed or adaptable for reasoning, highlighting the latest advancements in various reasoning tasks, methods, and benchmarks. We then delve into the potential future directions behind the emergence of reasoning abilities within foundation models. We also discuss the relevance of multimodal learning, autonomous agents, and super alignment in the context of reasoning. By discussing these future research directions, we hope to inspire researchers in their exploration of this field, stimulate further advancements in reasoning with foundation models, and contribute to the development of AGI.

12.5LGOct 17, 2024Code
A Common Pitfall of Margin-based Language Model Alignment: Gradient Entanglement

Hui Yuan, Yifan Zeng, Yue Wu et al.

Reinforcement Learning from Human Feedback (RLHF) has become the predominant approach for language model (LM) alignment. At its core, RLHF uses a margin-based loss for preference optimization, specifying ideal LM behavior only by the difference between preferred and dispreferred responses. In this paper, we identify a common pitfall of margin-based methods -- the under-specification of ideal LM behavior on preferred and dispreferred responses individually, which leads to two unintended consequences as the margin increases: (1) The probability of dispreferred (e.g., unsafe) responses may increase, resulting in potential safety alignment failures. (2) The probability of preferred responses may decrease, even when those responses are ideal. We demystify the reasons behind these problematic behaviors: margin-based losses couple the change in the preferred probability to the gradient of the dispreferred one, and vice versa, often preventing the preferred probability from increasing while the dispreferred one decreases, and thus causing a synchronized increase or decrease in both probabilities. We term this effect, inherent in margin-based objectives, gradient entanglement. Formally, we derive conditions for general margin-based alignment objectives under which gradient entanglement becomes concerning: the inner product of the gradients of preferred and dispreferred log-probabilities is large relative to the individual gradient norms. We theoretically investigate why such inner products can be large when aligning language models and empirically validate our findings. Empirical implications of our framework extend to explaining important differences in the training dynamics of various preference optimization algorithms, and suggesting potential algorithm designs to mitigate the under-specification issue of margin-based methods and thereby improving language model alignment.

6.1CLJun 1, 2024
Enhancing Text Authenticity: A Novel Hybrid Approach for AI-Generated Text Detection

Ye Zhang, Qian Leng, Mengran Zhu et al.

The rapid advancement of Large Language Models (LLMs) has ushered in an era where AI-generated text is increasingly indistinguishable from human-generated content. Detecting AI-generated text has become imperative to combat misinformation, ensure content authenticity, and safeguard against malicious uses of AI. In this paper, we propose a novel hybrid approach that combines traditional TF-IDF techniques with advanced machine learning models, including Bayesian classifiers, Stochastic Gradient Descent (SGD), Categorical Gradient Boosting (CatBoost), and 12 instances of Deberta-v3-large models. Our approach aims to address the challenges associated with detecting AI-generated text by leveraging the strengths of both traditional feature extraction methods and state-of-the-art deep learning models. Through extensive experiments on a comprehensive dataset, we demonstrate the effectiveness of our proposed method in accurately distinguishing between human and AI-generated text. Our approach achieves superior performance compared to existing methods. This research contributes to the advancement of AI-generated text detection techniques and lays the foundation for developing robust solutions to mitigate the challenges posed by AI-generated content.

18.3AIMay 24, 2023Code
SPRING: Studying the Paper and Reasoning to Play Games

Yue Wu, Shrimai Prabhumoye, So Yeon Min et al.

Open-world survival games pose significant challenges for AI algorithms due to their multi-tasking, deep exploration, and goal prioritization requirements. Despite reinforcement learning (RL) being popular for solving games, its high sample complexity limits its effectiveness in complex open-world games like Crafter or Minecraft. We propose a novel approach, SPRING, to read the game's original academic paper and use the knowledge learned to reason and play the game through a large language model (LLM). Prompted with the LaTeX source as game context and a description of the agent's current observation, our SPRING framework employs a directed acyclic graph (DAG) with game-related questions as nodes and dependencies as edges. We identify the optimal action to take in the environment by traversing the DAG and calculating LLM responses for each node in topological order, with the LLM's answer to final node directly translating to environment actions. In our experiments, we study the quality of in-context "reasoning" induced by different forms of prompts under the setting of the Crafter open-world environment. Our experiments suggest that LLMs, when prompted with consistent chain-of-thought, have great potential in completing sophisticated high-level trajectories. Quantitatively, SPRING with GPT-4 outperforms all state-of-the-art RL baselines, trained for 1M steps, without any training. Finally, we show the potential of games as a test bed for LLMs.

3.4CVMay 7, 2019Code
Spatially Constrained GAN for Face and Fashion Synthesis

Songyao Jiang, Hongfu Liu, Yue Wu et al.

Image generation has raised tremendous attention in both academic and industrial areas, especially for the conditional and target-oriented image generation, such as criminal portrait and fashion design. Although the current studies have achieved preliminary results along this direction, they always focus on class labels as the condition where spatial contents are randomly generated from latent vectors. Edge details are usually blurred since spatial information is difficult to preserve. In light of this, we propose a novel Spatially Constrained Generative Adversarial Network (SCGAN), which decouples the spatial constraints from the latent vector and makes these constraints feasible as additional controllable signals. To enhance the spatial controllability, a generator network is specially designed to take a semantic segmentation, a latent vector and an attribute-level label as inputs step by step. Besides, a segmentor network is constructed to impose spatial constraints on the generator. Experimentally, we provide both visual and quantitative results on CelebA and DeepFashion datasets, and demonstrate that the proposed SCGAN is very effective in controlling the spatial contents as well as generating high-quality images.

5.2CVFeb 24, 2018
Generating retinal flow maps from structural optical coherence tomography with artificial intelligence

Cecilia S. Lee, Ariel J. Tyring, Yue Wu et al.

Despite significant advances in artificial intelligence (AI) for computer vision, its application in medical imaging has been limited by the burden and limits of expert-generated labels. We used images from optical coherence tomography angiography (OCTA), a relatively new imaging modality that measures perfusion of the retinal vasculature, to train an AI algorithm to generate vasculature maps from standard structural optical coherence tomography (OCT) images of the same retinae, both exceeding the ability and bypassing the need for expert labeling. Deep learning was able to infer perfusion of microvasculature from structural OCT images with similar fidelity to OCTA and significantly better than expert clinicians (P < 0.00001). OCTA suffers from need of specialized hardware, laborious acquisition protocols, and motion artifacts; whereas our model works directly from standard OCT which are ubiquitous and quick to obtain, and allows unlocking of large volumes of previously collected standard OCT data both in existing clinical trials and clinical practice. This finding demonstrates a novel application of AI to medical imaging, whereby subtle regularities between different modalities are used to image the same body part and AI is used to generate detailed and accurate inferences of tissue function from structure imaging.