Yu Li

He Cao, Zijing Liu, Xingyu Lu et al.

The rapid evolution of artificial intelligence in drug discovery encounters challenges with generalization and extensive training, yet Large Language Models (LLMs) offer promise in reshaping interactions with complex molecular data. Our novel contribution, InstructMol, a multi-modal LLM, effectively aligns molecular structures with natural language via an instruction-tuning approach, utilizing a two-stage training strategy that adeptly combines limited domain-specific data with molecular and textual information. InstructMol showcases substantial performance improvements in drug discovery-related molecular tasks, surpassing leading LLMs and significantly reducing the gap with specialized models, thereby establishing a robust foundation for a versatile and dependable drug discovery assistant.

Yu Li, Chun-Yen Chen, Dian Yu et al.

This paper reports on progress towards building an online language learning tool to provide learners with conversational experience by using dialog systems as conversation practice partners. Our system can adapt to users' language proficiency on the fly. We also provide automatic grammar error feedback to help users learn from their mistakes. According to our first adopters, our system is entertaining and useful. Furthermore, we will provide the learning technology community a large-scale conversation dataset on language learning and grammar correction. Our next step is to make our system more adaptive to user profile information by using reinforcement learning algorithms.

Wenti Yin, Huaxin Zhang, Xiang Wang et al.

Recent advancements in weakly-supervised video anomaly detection have achieved remarkable performance by applying the multiple instance learning paradigm based on multimodal foundation models such as CLIP to highlight anomalous instances and classify categories. However, their objectives may tend to detect the most salient response segments, while neglecting to mine diverse normal patterns separated from anomalies, and are prone to category confusion due to similar appearance, leading to unsatisfactory fine-grained classification results. Therefore, we propose a novel Disentangled Semantic Alignment Network (DSANet) to explicitly separate abnormal and normal features from coarse-grained and fine-grained aspects, enhancing the distinguishability. Specifically, at the coarse-grained level, we introduce a self-guided normality modeling branch that reconstructs input video features under the guidance of learned normal prototypes, encouraging the model to exploit normality cues inherent in the video, thereby improving the temporal separation of normal patterns and anomalous events. At the fine-grained level, we present a decoupled contrastive semantic alignment mechanism, which first temporally decomposes each video into event-centric and background-centric components using frame-level anomaly scores and then applies visual-language contrastive learning to enhance class-discriminative representations. Comprehensive experiments on two standard benchmarks, namely XD-Violence and UCF-Crime, demonstrate that DSANet outperforms existing state-of-the-art methods.

Qiming Zou, Ke Lu, Yu Li

Owing to the rapid growth number of vehicles, urban traffic congestion has become more and more severe in the last decades. As an effective approach, Model Predictive Control (MPC) has been applied to urban traffic signal control system. However, the potentially high online computation burden may limit its further application for real scenarios. In this paper, a new approach based on online active set strategy is proposed to improve the real-time performance of MPC-based traffic controller by reducing the online computing time. This approach divides one control cycle into several sequential sampling intervals. In each interval, online active set method is applied to solve quadratic programming (QP) of traffic signal control model, by searching the optimal solution starting at the optimal solution of previous interval in the feasible region. The most appealing property of this approach lies in that it can distribute the computational complexity into several sample intervals, instead of imposing heavy computation burden at each end of control cycle. The simulation experiments show that this breakthrough approach can obviously reduce the online computational complexity, and increase the applicability of the MPC in real-life traffic networks.

Yu Wang, Xiaogeng Liu, Yu Li et al.

With the advent and widespread deployment of Multimodal Large Language Models (MLLMs), the imperative to ensure their safety has become increasingly pronounced. However, with the integration of additional modalities, MLLMs are exposed to new vulnerabilities, rendering them prone to structured-based jailbreak attacks, where semantic content (e.g., "harmful text") has been injected into the images to mislead MLLMs. In this work, we aim to defend against such threats. Specifically, we propose \textbf{Ada}ptive \textbf{Shield} Prompting (\textbf{AdaShield}), which prepends inputs with defense prompts to defend MLLMs against structure-based jailbreak attacks without fine-tuning MLLMs or training additional modules (e.g., post-stage content detector). Initially, we present a manually designed static defense prompt, which thoroughly examines the image and instruction content step by step and specifies response methods to malicious queries. Furthermore, we introduce an adaptive auto-refinement framework, consisting of a target MLLM and a LLM-based defense prompt generator (Defender). These components collaboratively and iteratively communicate to generate a defense prompt. Extensive experiments on the popular structure-based jailbreak attacks and benign datasets show that our methods can consistently improve MLLMs' robustness against structure-based jailbreak attacks without compromising the model's general capabilities evaluated on standard benign tasks. Our code is available at https://github.com/rain305f/AdaShield.

Li Yu, Hongchao Zhong, Longkun Zou et al.

Recent progress of semantic point clouds analysis is largely driven by synthetic data (e.g., the ModelNet and the ShapeNet), which are typically complete, well-aligned and noisy free. Therefore, representations of those ideal synthetic point clouds have limited variations in the geometric perspective and can gain good performance on a number of 3D vision tasks such as point cloud classification. In the context of unsupervised domain adaptation (UDA), representation learning designed for synthetic point clouds can hardly capture domain invariant geometric patterns from incomplete and noisy point clouds. To address such a problem, we introduce a novel scheme for induced geometric invariance of point cloud representations across domains, via regularizing representation learning with two self-supervised geometric augmentation tasks. On one hand, a novel pretext task of predicting translation distances of augmented samples is proposed to alleviate centroid shift of point clouds due to occlusion and noises. On the other hand, we pioneer an integration of the relational self-supervised learning on geometrically-augmented point clouds in a cascade manner, utilizing the intrinsic relationship of augmented variants and other samples as extra constraints of cross-domain geometric features. Experiments on the PointDA-10 dataset demonstrate the effectiveness of the proposed method, achieving the state-of-the-art performance.

Di Wu, Shicai Fan, Xue Zhou et al.

Reconstruction-based methods have been commonly used for unsupervised anomaly detection, in which a normal image is reconstructed and compared with the given test image to detect and locate anomalies. Recently, diffusion models have shown promising applications for anomaly detection due to their powerful generative ability. However, these models lack strict mathematical support for normal image reconstruction and unexpectedly suffer from low reconstruction quality. To address these issues, this paper proposes a novel and highly-interpretable method named Masked Diffusion Posterior Sampling (MDPS). In MDPS, the problem of normal image reconstruction is mathematically modeled as multiple diffusion posterior sampling for normal images based on the devised masked noisy observation model and the diffusion-based normal image prior under Bayesian framework. Using a metric designed from pixel-level and perceptual-level perspectives, MDPS can effectively compute the difference map between each normal posterior sample and the given test image. Anomaly scores are obtained by averaging all difference maps for multiple posterior samples. Exhaustive experiments on MVTec and BTAD datasets demonstrate that MDPS can achieve state-of-the-art performance in normal image reconstruction quality as well as anomaly detection and localization.

Yu Li, Hu Wang, Juanjuan Liu

With the increase of the nonlinearity and dimension, it is difficult for the present popular metamodeling techniques to construct reliable metamodels. To address this problem, Convolutional Neural Network (CNN) is introduced to construct a highly accurate metamodel efficiently. Considering the inherent characteristics of the CNN, it is a potential modeling tool to handle highly nonlinear and dimensional problems (hundreds-dimensional problems) with the limited training samples. In order to evaluate the proposed CNN metamodel for hundreds-dimensional and strong nonlinear problems, CNN is compared with other metamodeling techniques. Furthermore, several high-dimensional analytical functions are also employed to test the CNN metamodel. Testing and comparisons confirm the efficiency and capability of the CNN metamodel for hundreds-dimensional and strong nonlinear problems. Moreover, the proposed CNN metamodel is also applied to IsoGeometric Analysis (IGA)-based optimization successfully.