Xiang Wan

Zhihong Chen, Yuhao Du, Jinpeng Hu et al.

Medical vision-and-language pre-training provides a feasible solution to extract effective vision-and-language representations from medical images and texts. However, few studies have been dedicated to this field to facilitate medical vision-and-language understanding. In this paper, we propose a self-supervised learning paradigm with multi-modal masked autoencoders (M$^3$AE), which learn cross-modal domain knowledge by reconstructing missing pixels and tokens from randomly masked images and texts. There are three key designs to make this simple approach work. First, considering the different information densities of vision and language, we adopt different masking ratios for the input image and text, where a considerably larger masking ratio is used for images. Second, we use visual and textual features from different layers to perform the reconstruction to deal with different levels of abstraction in visual and language. Third, we develop different designs for vision and language decoders (i.e., a Transformer for vision and a multi-layer perceptron for language). To perform a comprehensive evaluation and facilitate further research, we construct a medical vision-and-language benchmark including three tasks. Experimental results demonstrate the effectiveness of our approach, where state-of-the-art results are achieved on all downstream tasks. Besides, we conduct further analysis to better verify the effectiveness of different components of our approach and various settings of pre-training. The source code is available at~\url{https://github.com/zhjohnchan/M3AE}.

Huang Huang, Fei Yu, Jianqing Zhu et al.

This paper is devoted to the development of a localized Large Language Model (LLM) specifically for Arabic, a language imbued with unique cultural characteristics inadequately addressed by current mainstream models. Significant concerns emerge when addressing cultural sensitivity and local values. To address this, the paper proposes a comprehensive solution that includes further pre-training with Arabic texts, Supervised Fine-Tuning (SFT) utilizing native Arabic instructions, and GPT-4 responses in Arabic, alongside Reinforcement Learning with AI Feedback (RLAIF) employing a reward model attuned to local culture and values. The goal is to cultivate culturally cognizant and value-aligned Arabic LLMs capable of accommodating the diverse, application-specific needs of Arabic-speaking communities. Comprehensive evaluations reveal that the resulting model, dubbed `AceGPT', sets the state-of-the-art standard for open Arabic LLMs across various benchmarks. Codes, data, and models are in https://github.com/FreedomIntelligence/AceGPT.

Zhihong Chen, Feng Jiang, Junying Chen et al.

This paper presents our efforts to democratize ChatGPT across language. We release a large language model "Phoenix", achieving competitive performance among open-source English and Chinese models while excelling in languages with limited resources (covering both Latin and non-Latin languages). We believe this work will be beneficial to make ChatGPT more accessible, especially in countries where people cannot use ChatGPT due to restrictions from OpenAI or local goverments. Our data, code, and models are available at https://github.com/FreedomIntelligence/LLMZoo.

Ruifei Zhang, Peiwen Lai, Xiang Wan et al.

Automatic and accurate polyp segmentation plays an essential role in early colorectal cancer diagnosis. However, it has always been a challenging task due to 1) the diverse shape, size, brightness and other appearance characteristics of polyps, 2) the tiny contrast between concealed polyps and their surrounding regions. To address these problems, we propose a lesion-aware dynamic network (LDNet) for polyp segmentation, which is a traditional u-shape encoder-decoder structure incorporated with a dynamic kernel generation and updating scheme. Specifically, the designed segmentation head is conditioned on the global context features of the input image and iteratively updated by the extracted lesion features according to polyp segmentation predictions. This simple but effective scheme endows our model with powerful segmentation performance and generalization capability. Besides, we utilize the extracted lesion representation to enhance the feature contrast between the polyp and background regions by a tailored lesion-aware cross-attention module (LCA), and design an efficient self-attention module (ESA) to capture long-range context relations, further improving the segmentation accuracy. Extensive experiments on four public polyp benchmarks and our collected large-scale polyp dataset demonstrate the superior performance of our method compared with other state-of-the-art approaches. The source code is available at https://github.com/ReaFly/LDNet.

Yuanfeng Ji, Haotian Bai, Jie Yang et al.

Despite the considerable progress in automatic abdominal multi-organ segmentation from CT/MRI scans in recent years, a comprehensive evaluation of the models' capabilities is hampered by the lack of a large-scale benchmark from diverse clinical scenarios. Constraint by the high cost of collecting and labeling 3D medical data, most of the deep learning models to date are driven by datasets with a limited number of organs of interest or samples, which still limits the power of modern deep models and makes it difficult to provide a fully comprehensive and fair estimate of various methods. To mitigate the limitations, we present AMOS, a large-scale, diverse, clinical dataset for abdominal organ segmentation. AMOS provides 500 CT and 100 MRI scans collected from multi-center, multi-vendor, multi-modality, multi-phase, multi-disease patients, each with voxel-level annotations of 15 abdominal organs, providing challenging examples and test-bed for studying robust segmentation algorithms under diverse targets and scenarios. We further benchmark several state-of-the-art medical segmentation models to evaluate the status of the existing methods on this new challenging dataset. We have made our datasets, benchmark servers, and baselines publicly available, and hope to inspire future research. Information can be found at https://amos22.grand-challenge.org.

Zhihong Chen, Yaling Shen, Yan Song et al.

Medical imaging plays a significant role in clinical practice of medical diagnosis, where the text reports of the images are essential in understanding them and facilitating later treatments. By generating the reports automatically, it is beneficial to help lighten the burden of radiologists and significantly promote clinical automation, which already attracts much attention in applying artificial intelligence to medical domain. Previous studies mainly follow the encoder-decoder paradigm and focus on the aspect of text generation, with few studies considering the importance of cross-modal mappings and explicitly exploit such mappings to facilitate radiology report generation. In this paper, we propose a cross-modal memory networks (CMN) to enhance the encoder-decoder framework for radiology report generation, where a shared memory is designed to record the alignment between images and texts so as to facilitate the interaction and generation across modalities. Experimental results illustrate the effectiveness of our proposed model, where state-of-the-art performance is achieved on two widely used benchmark datasets, i.e., IU X-Ray and MIMIC-CXR. Further analyses also prove that our model is able to better align information from radiology images and texts so as to help generating more accurate reports in terms of clinical indicators.

Haotian Bai, Ruimao Zhang, Jiong Wang et al.

Weakly Supervised Object Localization (WSOL), which aims to localize objects by only using image-level labels, has attracted much attention because of its low annotation cost in real applications. Recent studies leverage the advantage of self-attention in visual Transformer for long-range dependency to re-active semantic regions, aiming to avoid partial activation in traditional class activation mapping (CAM). However, the long-range modeling in Transformer neglects the inherent spatial coherence of the object, and it usually diffuses the semantic-aware regions far from the object boundary, making localization results significantly larger or far smaller. To address such an issue, we introduce a simple yet effective Spatial Calibration Module (SCM) for accurate WSOL, incorporating semantic similarities of patch tokens and their spatial relationships into a unified diffusion model. Specifically, we introduce a learnable parameter to dynamically adjust the semantic correlations and spatial context intensities for effective information propagation. In practice, SCM is designed as an external module of Transformer, and can be removed during inference to reduce the computation cost. The object-sensitive localization ability is implicitly embedded into the Transformer encoder through optimization in the training phase. It enables the generated attention maps to capture the sharper object boundaries and filter the object-irrelevant background area. Extensive experimental results demonstrate the effectiveness of the proposed method, which significantly outperforms its counterpart TS-CAM on both CUB-200 and ImageNet-1K benchmarks. The code is available at https://github.com/164140757/SCM.

Jinpeng Hu, Zhuo Li, Zhihong Chen et al.

The impression section of a radiology report summarizes the most prominent observation from the findings section and is the most important section for radiologists to communicate to physicians. Summarizing findings is time-consuming and can be prone to error for inexperienced radiologists, and thus automatic impression generation has attracted substantial attention. With the encoder-decoder framework, most previous studies explore incorporating extra knowledge (e.g., static pre-defined clinical ontologies or extra background information). Yet, they encode such knowledge by a separate encoder to treat it as an extra input to their models, which is limited in leveraging their relations with the original findings. To address the limitation, we propose a unified framework for exploiting both extra knowledge and the original findings in an integrated way so that the critical information (i.e., key words and their relations) can be extracted in an appropriate way to facilitate impression generation. In detail, for each input findings, it is encoded by a text encoder, and a graph is constructed through its entities and dependency tree. Then, a graph encoder (e.g., graph neural networks (GNNs)) is adopted to model relation information in the constructed graph. Finally, to emphasize the key words in the findings, contrastive learning is introduced to map positive samples (constructed by masking non-key words) closer and push apart negative ones (constructed by masking key words). The experimental results on OpenI and MIMIC-CXR confirm the effectiveness of our proposed method.

Yang Liu, Jinpeng Hu, Xiang Wan et al.

Few-Shot Relation Extraction aims at predicting the relation for a pair of entities in a sentence by training with a few labelled examples in each relation. Some recent works have introduced relation information (i.e., relation labels or descriptions) to assist model learning based on Prototype Network. However, most of them constrain the prototypes of each relation class implicitly with relation information, generally through designing complex network structures, like generating hybrid features, combining with contrastive learning or attention networks. We argue that relation information can be introduced more explicitly and effectively into the model. Thus, this paper proposes a direct addition approach to introduce relation information. Specifically, for each relation class, the relation representation is first generated by concatenating two views of relations (i.e., [CLS] token embedding and the mean value of embeddings of all tokens) and then directly added to the original prototype for both train and prediction. Experimental results on the benchmark dataset FewRel 1.0 show significant improvements and achieve comparable results to the state-of-the-art, which demonstrates the effectiveness of our proposed approach. Besides, further analyses verify that the direct addition is a much more effective way to integrate the relation representations and the original prototypes.

Zhanghao Chen, Yifei Sun, Wenjian Qin et al.

Chest X-rays (CXRs) are commonly utilized as a low-dose modality for lung screening. Nonetheless, the efficacy of CXRs is somewhat impeded, given that approximately 75% of the lung area overlaps with bone, which in turn hampers the detection and diagnosis of diseases. As a remedial measure, bone suppression techniques have been introduced. The current dual-energy subtraction imaging technique in the clinic requires costly equipment and subjects being exposed to high radiation. To circumvent these issues, deep learning-based image generation algorithms have been proposed. However, existing methods fall short in terms of producing high-quality images and capturing texture details, particularly with pulmonary vessels. To address these issues, this paper proposes a new bone suppression framework, termed BS-Diff, that comprises a conditional diffusion model equipped with a U-Net architecture and a simple enhancement module to incorporate an autoencoder. Our proposed network cannot only generate soft tissue images with a high bone suppression rate but also possesses the capability to capture fine image details. Additionally, we compiled the largest dataset since 2010, including data from 120 patients with high-definition, high-resolution paired CXRs and soft tissue images collected by our affiliated hospital. Extensive experiments, comparative analyses, ablation studies, and clinical evaluations indicate that the proposed BS-Diff outperforms several bone-suppression models across multiple metrics. Our code can be accessed at https://github.com/Benny0323/BS-Diff.

Zhihong Chen, Guanbin Li, Xiang Wan

Medical vision-and-language pre-training (Med-VLP) has received considerable attention owing to its applicability to extracting generic vision-and-language representations from medical images and texts. Most existing methods mainly contain three elements: uni-modal encoders (i.e., a vision encoder and a language encoder), a multi-modal fusion module, and pretext tasks, with few studies considering the importance of medical domain expert knowledge and explicitly exploiting such knowledge to facilitate Med-VLP. Although there exist knowledge-enhanced vision-and-language pre-training (VLP) methods in the general domain, most require off-the-shelf toolkits (e.g., object detectors and scene graph parsers), which are unavailable in the medical domain. In this paper, we propose a systematic and effective approach to enhance Med-VLP by structured medical knowledge from three perspectives. First, considering knowledge can be regarded as the intermediate medium between vision and language, we align the representations of the vision encoder and the language encoder through knowledge. Second, we inject knowledge into the multi-modal fusion model to enable the model to perform reasoning using knowledge as the supplementation of the input image and text. Third, we guide the model to put emphasis on the most critical information in images and texts by designing knowledge-induced pretext tasks. To perform a comprehensive evaluation and facilitate further research, we construct a medical vision-and-language benchmark including three tasks. Experimental results illustrate the effectiveness of our approach, where state-of-the-art performance is achieved on all downstream tasks. Further analyses explore the effects of different components of our approach and various settings of pre-training.

Jinpeng Hu, Yaling Shen, Yang Liu et al.

Named entity recognition (NER) is a fundamental and important task in NLP, aiming at identifying named entities (NEs) from free text. Recently, since the multi-head attention mechanism applied in the Transformer model can effectively capture longer contextual information, Transformer-based models have become the mainstream methods and have achieved significant performance in this task. Unfortunately, although these models can capture effective global context information, they are still limited in the local feature and position information extraction, which is critical in NER. In this paper, to address this limitation, we propose a novel Hero-Gang Neural structure (HGN), including the Hero and Gang module, to leverage both global and local information to promote NER. Specifically, the Hero module is composed of a Transformer-based encoder to maintain the advantage of the self-attention mechanism, and the Gang module utilizes a multi-window recurrent module to extract local features and position information under the guidance of the Hero module. Afterward, the proposed multi-window attention effectively combines global information and multiple local features for predicting entity labels. Experimental results on several benchmark datasets demonstrate the effectiveness of our proposed model.

Yuhao Du, Zhuo Li, Pengyu Cheng et al.

Despite the substantial advancements in artificial intelligence, large language models (LLMs) remain being challenged by generation safety. With adversarial jailbreaking prompts, one can effortlessly induce LLMs to output harmful content, causing unexpected negative social impacts. This vulnerability highlights the necessity for robust LLM red-teaming strategies to identify and mitigate such risks before large-scale application. To detect specific types of risks, we propose a novel red-teaming method that $\textbf{A}$ttacks LLMs with $\textbf{T}$arget $\textbf{Toxi}$c $\textbf{A}$nswers ($\textbf{Atoxia}$). Given a particular harmful answer, Atoxia generates a corresponding user query and a misleading answer opening to examine the internal defects of a given LLM. The proposed attacker is trained within a reinforcement learning scheme with the LLM outputting probability of the target answer as the reward. We verify the effectiveness of our method on various red-teaming benchmarks, such as AdvBench and HH-Harmless. The empirical results demonstrate that Atoxia can successfully detect safety risks in not only open-source models but also state-of-the-art black-box models such as GPT-4o.

Zhihong Chen, Shizhe Diao, Benyou Wang et al.

Medical vision-and-language pre-training (Med-VLP) has shown promising improvements on many downstream medical tasks owing to its applicability to extracting generic representations from medical images and texts. Practically, there exist two typical types, \textit{i.e.}, the fusion-encoder type and the dual-encoder type, depending on whether a heavy fusion module is used. The former is superior at multi-modal tasks owing to the sufficient interaction between modalities; the latter is good at uni-modal and cross-modal tasks due to the single-modality encoding ability. To take advantage of these two types, we propose an effective yet straightforward scheme named PTUnifier to unify the two types. We first unify the input format by introducing visual and textual prompts, which serve as a feature bank that stores the most representative images/texts. By doing so, a single model could serve as a \textit{foundation model} that processes various tasks adopting different input formats (\textit{i.e.}, image-only, text-only, and image-text-pair). Furthermore, we construct a prompt pool (instead of static ones) to improve diversity and scalability. Experimental results show that our approach achieves state-of-the-art results on a broad range of tasks, spanning uni-modal tasks (\textit{i.e.}, image/text classification and text summarization), cross-modal tasks (\textit{i.e.}, image-to-text generation and image-text/text-image retrieval), and multi-modal tasks (\textit{i.e.}, visual question answering), demonstrating the effectiveness of our approach. Note that the adoption of prompts is orthogonal to most existing Med-VLP approaches and could be a beneficial and complementary extension to these approaches.

Junying Chen, Xidong Wang, Ke Ji et al.

Adapting a language model into a specific domain, a.k.a `domain adaption', is a common practice when specialized knowledge, e.g. medicine, is not encapsulated in a general language model like Llama2. The challenge lies in the heterogeneity of data across the two training stages, as it varies in languages, genres, or formats. To tackle this and simplify the learning protocol, we propose to transform heterogeneous data, from the both pre-training and supervised stages, into a unified, simple input-output pair format. We validate the new protocol in the domains where proprietary LLMs like ChatGPT perform relatively poorly, such as Traditional Chinese Medicine. The developed model, HuatuoGPT-II, has shown state-of-the-art performance in Chinese medicine domain on a number of benchmarks, e.g. medical licensing exams. It even outperforms proprietary models like ChatGPT and GPT-4 in some aspects, especially in Traditional Chinese Medicine. Expert manual evaluations further validate HuatuoGPT-II's advantages over existing LLMs. Notably, HuatuoGPT-II was benchmarked in a fresh Chinese National Medical Licensing Examination where it achieved the best performance, showcasing not only its effectiveness but also its generalization capabilities.

Jinpeng Hu, Zhihong Chen, Yang Liu et al.

The impression is crucial for the referring physicians to grasp key information since it is concluded from the findings and reasoning of radiologists. To alleviate the workload of radiologists and reduce repetitive human labor in impression writing, many researchers have focused on automatic impression generation. However, recent works on this task mainly summarize the corresponding findings and pay less attention to the radiology images. In clinical, radiographs can provide more detailed valuable observations to enhance radiologists' impression writing, especially for complicated cases. Besides, each sentence in findings usually focuses on single anatomy, so they only need to be matched to corresponding anatomical regions instead of the whole image, which is beneficial for textual and visual features alignment. Therefore, we propose a novel anatomy-enhanced multimodal model to promote impression generation. In detail, we first construct a set of rules to extract anatomies and put these prompts into each sentence to highlight anatomy characteristics. Then, two separate encoders are applied to extract features from the radiograph and findings. Afterward, we utilize a contrastive learning module to align these two representations at the overall level and use a co-attention to fuse them at the sentence level with the help of anatomy-enhanced sentence representation. Finally, the decoder takes the fused information as the input to generate impressions. The experimental results on two benchmark datasets confirm the effectiveness of the proposed method, which achieves state-of-the-art results.

Chuyi Kong, Yaxin Fan, Xiang Wan et al.

The unparalleled performance of closed-sourced ChatGPT has sparked efforts towards its democratization, with notable strides made by leveraging real user and ChatGPT dialogues, as evidenced by Vicuna. However, due to challenges in gathering dialogues involving human participation, current endeavors like Baize and UltraChat rely on ChatGPT conducting roleplay to simulate humans based on instructions, resulting in overdependence on seeds, diminished human-likeness, limited topic diversity, and an absence of genuine multi-round conversational dynamics. To address the above issues, we propose a paradigm to simulate human behavior better and explore the benefits of incorporating more human-like questions in multi-turn conversations. Specifically, we directly target human questions extracted from genuine human-machine conversations as a learning goal and provide a novel user simulator called `Socratic'. The experimental results show our response model, `PlatoLM', achieves SoTA performance among LLaMA-based 7B models in MT-Bench. Our findings further demonstrate that our method introduces highly human-like questioning patterns and rich topic structures, which can teach the response model better than previous works in multi-round conversations.

Zhihong Chen, Guiming Hardy Chen, Shizhe Diao et al.

Masked language modeling (MLM) has been one of the most popular pretraining recipes in natural language processing, e.g., BERT, one of the representative models. Recently, contrastive language-image pretraining (CLIP) has also attracted attention, especially its vision models that achieve excellent performance on a broad range of vision tasks. However, few studies are dedicated to studying the text encoders learned by CLIP. In this paper, we analyze the difference between BERT-style and CLIP-style text encoders from three experiments: (i) general text understanding, (ii) vision-centric text understanding, and (iii) text-to-image generation. Experimental analyses show that although CLIP-style text encoders underperform BERT-style ones for general text understanding tasks, they are equipped with a unique ability, i.e., synesthesia, for the cross-modal association, which is more similar to the senses of humans.

Wei Lou, Xiang Wan, Guanbin Li et al.

Nuclei classification provides valuable information for histopathology image analysis. However, the large variations in the appearance of different nuclei types cause difficulties in identifying nuclei. Most neural network based methods are affected by the local receptive field of convolutions, and pay less attention to the spatial distribution of nuclei or the irregular contour shape of a nucleus. In this paper, we first propose a novel polygon-structure feature learning mechanism that transforms a nucleus contour into a sequence of points sampled in order, and employ a recurrent neural network that aggregates the sequential change in distance between key points to obtain learnable shape features. Next, we convert a histopathology image into a graph structure with nuclei as nodes, and build a graph neural network to embed the spatial distribution of nuclei into their representations. To capture the correlations between the categories of nuclei and their surrounding tissue patterns, we further introduce edge features that are defined as the background textures between adjacent nuclei. Lastly, we integrate both polygon and graph structure learning mechanisms into a whole framework that can extract intra and inter-nucleus structural characteristics for nuclei classification. Experimental results show that the proposed framework achieves significant improvements compared to the state-of-the-art methods.

Junjia Huang, Haofeng Li, Guanbin Li et al.

Self-supervised learning methods based on image patch reconstruction have witnessed great success in training auto-encoders, whose pre-trained weights can be transferred to fine-tune other downstream tasks of image understanding. However, existing methods seldom study the various importance of reconstructed patches and the symmetry of anatomical structures, when they are applied to 3D medical images. In this paper we propose a novel Attentive Symmetric Auto-encoder (ASA) based on Vision Transformer (ViT) for 3D brain MRI segmentation tasks. We conjecture that forcing the auto-encoder to recover informative image regions can harvest more discriminative representations, than to recover smooth image patches. Then we adopt a gradient based metric to estimate the importance of each image patch. In the pre-training stage, the proposed auto-encoder pays more attention to reconstruct the informative patches according to the gradient metrics. Moreover, we resort to the prior of brain structures and develop a Symmetric Position Encoding (SPE) method to better exploit the correlations between long-range but spatially symmetric regions to obtain effective features. Experimental results show that our proposed attentive symmetric auto-encoder outperforms the state-of-the-art self-supervised learning methods and medical image segmentation models on three brain MRI segmentation benchmarks.

Ridong Han, Tao Peng, Benyou Wang et al.

Document-level relation extraction faces two overlooked challenges: long-tail problem and multi-label problem. Previous work focuses mainly on obtaining better contextual representations for entity pairs, hardly address the above challenges. In this paper, we analyze the co-occurrence correlation of relations, and introduce it into DocRE task for the first time. We argue that the correlations can not only transfer knowledge between data-rich relations and data-scarce ones to assist in the training of tailed relations, but also reflect semantic distance guiding the classifier to identify semantically close relations for multi-label entity pairs. Specifically, we use relation embedding as a medium, and propose two co-occurrence prediction sub-tasks from both coarse- and fine-grained perspectives to capture relation correlations. Finally, the learned correlation-aware embeddings are used to guide the extraction of relational facts. Substantial experiments on two popular DocRE datasets are conducted, and our method achieves superior results compared to baselines. Insightful analysis also demonstrates the potential of relation correlations to address the above challenges.

Wentao Ge, Shunian Chen, Guiming Hardy Chen et al.

Multimodal large language models (MLLMs) have broadened the scope of AI applications. Existing automatic evaluation methodologies for MLLMs are mainly limited in evaluating queries without considering user experiences, inadequately addressing the nuances of creative and associative multimodal tasks. However, the open-ended and subjective nature of such tasks poses a significant challenge to the evaluation methodology, where it is difficult to define the ground-truth answers for them. To this end, in our paper, we propose a new evaluation paradigm for MLLMs, which is evaluating MLLMs with per-sample criteria using potent MLLM as the judge. To validate the feasibility and effectiveness of this paradigm, we design a benchmark, dubbed MLLM-Bench, by curating the evaluation samples across six comprehensive cognitive levels. We benchmark 21 popular MLLMs in a pairwise-comparison fashion, showing diverse performance across models. Moreover, the validity of our benchmark manifests itself in reaching 88.02% agreement with human evaluation. We contend that the proposed paradigm explores the potential of MLLMs as effective evaluation tools with the help of per-sample criteria. See online leaderboard at \url{https://mllm-bench.llmzoo.com}.

Guiming Hardy Chen, Shunian Chen, Ruifei Zhang et al.

Large vision-language models (LVLMs) have shown premise in a broad range of vision-language tasks with their strong reasoning and generalization capabilities. However, they require considerable computational resources for training and deployment. This study aims to bridge the performance gap between traditional-scale LVLMs and resource-friendly lite versions by adopting high-quality training data. To this end, we propose a comprehensive pipeline for generating a synthetic dataset. The key idea is to leverage strong proprietary models to generate (i) fine-grained image annotations for vision-language alignment and (ii) complex reasoning visual question-answering pairs for visual instruction fine-tuning, yielding 1.3M samples in total. We train a series of lite VLMs on the synthetic dataset and experimental results demonstrate the effectiveness of the proposed scheme, where they achieve competitive performance on 17 benchmarks among 4B LVLMs, and even perform on par with 7B/13B-scale models on various benchmarks. This work highlights the feasibility of adopting high-quality data in crafting more efficient LVLMs. We name our dataset \textit{ALLaVA}, and open-source it to research community for developing better resource-efficient LVLMs for wider usage.

Xuhao Shan, Xinyang Li, Ruiquan Ge et al.

Intracerebral Hemorrhage (ICH) is a severe condition resulting from damaged brain blood vessel ruptures, often leading to complications and fatalities. Timely and accurate prognosis and management are essential due to its high mortality rate. However, conventional methods heavily rely on subjective clinician expertise, which can lead to inaccurate diagnoses and delays in treatment. Artificial intelligence (AI) models have been explored to assist clinicians, but many prior studies focused on model modification without considering domain knowledge. This paper introduces a novel deep learning algorithm, GCS-ICHNet, which integrates multimodal brain CT image data and the Glasgow Coma Scale (GCS) score to improve ICH prognosis. The algorithm utilizes a transformer-based fusion module for assessment. GCS-ICHNet demonstrates high sensitivity 81.03% and specificity 91.59%, outperforming average clinicians and other state-of-the-art methods.

Xinlei Yu, Xinyang Li, Ruiquan Ge et al.

Intracerebral Hemorrhage (ICH) is the deadliest subtype of stroke, necessitating timely and accurate prognostic evaluation to reduce mortality and disability. However, the multi-factorial nature and complexity of ICH make methods based solely on computed tomography (CT) image features inadequate. Despite the capacity of cross-modal networks to fuse additional information, the effective combination of different modal features remains a significant challenge. In this study, we propose a joint-attention fusion-based 3D cross-modal network termed ICHPro that simulates the ICH prognosis interpretation process utilized by neurosurgeons. ICHPro includes a joint-attention fusion module to fuse features from CT images with demographic and clinical textual data. To enhance the representation of cross-modal features, we introduce a joint loss function. ICHPro facilitates the extraction of richer cross-modal features, thereby improving classification performance. Upon testing our method using a five-fold cross-validation, we achieved an accuracy of 89.11%, an F1 score of 0.8767, and an AUC value of 0.9429. These results outperform those obtained from other advanced methods based on the test dataset, thereby demonstrating the superior efficacy of ICHPro. The code is available at our Github: https://github.com/YU-deep/ICH.

Wei Lou, Guanbin Li, Xiang Wan et al.

Nuclei classification is a critical step in computer-aided diagnosis with histopathology images. In the past, various methods have employed graph neural networks (GNN) to analyze cell graphs that model inter-cell relationships by considering nuclei as vertices. However, they are limited by the GNN mechanism that only passes messages among local nodes via fixed edges. To address the issue, we develop a cell graph transformer (CGT) that treats nodes and edges as input tokens to enable learnable adjacency and information exchange among all nodes. Nevertheless, training the transformer with a cell graph presents another challenge. Poorly initialized features can lead to noisy self-attention scores and inferior convergence, particularly when processing the cell graphs with numerous connections. Thus, we further propose a novel topology-aware pretraining method that leverages a graph convolutional network (GCN) to learn a feature extractor. The pre-trained features may suppress unreasonable correlations and hence ease the finetuning of CGT. Experimental results suggest that the proposed cell graph transformer with topology-aware pretraining significantly improves the nuclei classification results, and achieves the state-of-the-art performance. Code and models are available at https://github.com/lhaof/CGT

Zhenhua Wu, Yanlin Jin, Liangdong Qiu et al.

Visualizing colonoscopy is crucial for medical auxiliary diagnosis to prevent undetected polyps in areas that are not fully observed. Traditional feature-based and depth-based reconstruction approaches usually end up with undesirable results due to incorrect point matching or imprecise depth estimation in realistic colonoscopy videos. Modern deep-based methods often require a sufficient number of ground truth samples, which are generally hard to obtain in optical colonoscopy. To address this issue, self-supervised and domain adaptation methods have been explored. However, these methods neglect geometry constraints and exhibit lower accuracy in predicting detailed depth. We thus propose a novel reconstruction pipeline with a bi-directional adaptation architecture named ToDER to get precise depth estimations. Furthermore, we carefully design a TNet module in our adaptation architecture to yield geometry constraints and obtain better depth quality. Estimated depth is finally utilized to reconstruct a reliable colon model for visualization. Experimental results demonstrate that our approach can precisely predict depth maps in both realistic and synthetic colonoscopy videos compared with other self-supervised and domain adaptation methods. Our method on realistic colonoscopy also shows the great potential for visualizing unobserved regions and preventing misdiagnoses.

Yuncheng Jiang, Zixun Zhang, Jun Wei et al.

AI-assisted lesion detection models play a crucial role in the early screening of cancer. However, previous image-based models ignore the inter-frame contextual information present in videos. On the other hand, video-based models capture the inter-frame context but are computationally expensive. To mitigate this contradiction, we delve into Video-to-Image knowledge distillation leveraging DEtection TRansformer (V2I-DETR) for the task of medical video lesion detection. V2I-DETR adopts a teacher-student network paradigm. The teacher network aims at extracting temporal contexts from multiple frames and transferring them to the student network, and the student network is an image-based model dedicated to fast prediction in inference. By distilling multi-frame contexts into a single frame, the proposed V2I-DETR combines the advantages of utilizing temporal contexts from video-based models and the inference speed of image-based models. Through extensive experiments, V2I-DETR outperforms previous state-of-the-art methods by a large margin while achieving the real-time inference speed (30 FPS) as the image-based model.

Hongbo Zhang, Junying Chen, Feng Jiang et al.

In this paper, we present HuatuoGPT, a large language model (LLM) for medical consultation. The core recipe of HuatuoGPT is to leverage both \textit{distilled data from ChatGPT} and \textit{real-world data from doctors} in the supervised fine-tuned stage. The responses of ChatGPT are usually detailed, well-presented and informative while it cannot perform like a doctor in many aspects, e.g. for integrative diagnosis. We argue that real-world data from doctors would be complementary to distilled data in the sense the former could tame a distilled language model to perform like doctors. To better leverage the strengths of both data, we train a reward model to align the language model with the merits that both data bring, following an RLAIF (reinforced learning from AI feedback) fashion. To evaluate and benchmark the models, we propose a comprehensive evaluation scheme (including automatic and manual metrics). Experimental results demonstrate that HuatuoGPT achieves state-of-the-art results in performing medical consultation among open-source LLMs in GPT-4 evaluation, human evaluation, and medical benchmark datasets. It is worth noting that by using additional real-world data and RLAIF, the distilled language model (i.e., HuatuoGPT) outperforms its teacher model ChatGPT in most cases. Our code, data, and models are publicly available at \url{https://github.com/FreedomIntelligence/HuatuoGPT}. The online demo is available at \url{https://www.HuatuoGPT.cn/}.

Hongbo Zhang, Xiang Wan, Benyou Wang

Pre-trained language models (PLMs) were considered to be able to store relational knowledge present in the training data. However, some relational knowledge seems to be discarded unsafely in PLMs due to \textbf{report bias}: low-frequency relational knowledge might be underexpressed compared to high-frequency one in PLMs. This gives us a hint that relational knowledge might not be redundant to the stored knowledge of PLMs, but rather be complementary. To additionally inject relational knowledge into PLMs, we propose a simple-yet-effective approach to inject relational knowledge into PLMs, which is inspired by three observations (namely, polymorphism, synonymous substitution, and association). In particular, we switch entities in the training corpus to related entities (either hypernyms/hyponyms/synonyms, or arbitrarily-related concepts). Experimental results show that the proposed approach could not only better capture relational knowledge, but also improve the performance in various biomedical downstream tasks. Our model is available in \url{https://github.com/StevenZHB/BioPLM_InjectingKnowledge}.

Jianquan Li, Xidong Wang, Xiangbo Wu et al.

In this paper, we release a largest ever medical Question Answering (QA) dataset with 26 million QA pairs. We benchmark many existing approaches in our dataset in terms of both retrieval and generation. Experimental results show that the existing models perform far lower than expected and the released dataset is still challenging in the pre-trained language model era. Moreover, we also experimentally show the benefit of the proposed dataset in many aspects: (i) trained models for other QA datasets in a zero-shot fashion; and (ii) as external knowledge for retrieval-augmented generation (RAG); and (iii) improving existing pre-trained language models by using the QA pairs as a pre-training corpus in continued training manner. We believe that this dataset will not only contribute to medical research but also facilitate both the patients and clinical doctors. See \url{https://github.com/FreedomIntelligence/Huatuo-26M}.

Chunhui Zhang, Guanjie Huang, Li Liu et al.

Unmanned aerial vehicle (UAV) tracking is of great significance for a wide range of applications, such as delivery and agriculture. Previous benchmarks in this area mainly focused on small-scale tracking problems while ignoring the amounts of data, types of data modalities, diversities of target categories and scenarios, and evaluation protocols involved, greatly hiding the massive power of deep UAV tracking. In this work, we propose WebUAV-3M, the largest public UAV tracking benchmark to date, to facilitate both the development and evaluation of deep UAV trackers. WebUAV-3M contains over 3.3 million frames across 4,500 videos and offers 223 highly diverse target categories. Each video is densely annotated with bounding boxes by an efficient and scalable semiautomatic target annotation (SATA) pipeline. Importantly, to take advantage of the complementary superiority of language and audio, we enrich WebUAV-3M by innovatively providing both natural language specifications and audio descriptions. We believe that such additions will greatly boost future research in terms of exploring language features and audio cues for multimodal UAV tracking. In addition, a fine-grained UAV tracking-under-scenario constraint (UTUSC) evaluation protocol and seven challenging scenario subtest sets are constructed to enable the community to develop, adapt and evaluate various types of advanced trackers. We provide extensive evaluations and detailed analyses of 43 representative trackers and envision future research directions in the field of deep UAV tracking and beyond. The dataset, toolkits and baseline results are available at \url{https://github.com/983632847/WebUAV-3M}.

Yuhao Du, Zhuo Li, Pengyu Cheng et al.

Reinforcement Learning from Human Feedback (RLHF) is crucial for aligning Large Language Models (LLMs) with human values. However, RLHF has been continuously challenged by its high complexity in implementation and computation consumption. Even with recent simplifications, such as Direct Preference Optimization (DPO) and Advantage Leftover Lunch (A-LoL), the problems of over-fitting and training instability remain hindering the alignment process from the expected optimal performance. To address the existing challenges, we propose a novel simplification of RLHF from the perspective of variational inference, called $\textbf{V}$ariational $\textbf{A}$lignment with $\textbf{R}$e-weighting ($\textbf{VAR}$). More specifically, by directly minimizing the distribution gap between the learning LLM policy and the optimal solution of RLHF, we transform the alignment objective into a reward-driven re-weighted supervised fine-tuning (SFT) form, which only requires minor adjustment on the SFT loss to obtain noticeable improvement on training stability and effectiveness. On comprehensive alignment and generation benchmarks, our VAR method has numerically achieved competitive performance in LLM alignment helpfulness and harmlessness.

Zhuo Li, He Zhao, Zhen Li et al.

Real-world datasets usually are class-imbalanced and corrupted by label noise. To solve the joint issue of long-tailed distribution and label noise, most previous works usually aim to design a noise detector to distinguish the noisy and clean samples. Despite their effectiveness, they may be limited in handling the joint issue effectively in a unified way. In this work, we develop a novel pseudo labeling method using class prototypes from the perspective of distribution matching, which can be solved with optimal transport (OT). By setting a manually-specific probability measure and using a learned transport plan to pseudo-label the training samples, the proposed method can reduce the side-effects of noisy and long-tailed data simultaneously. Then we introduce a simple yet effective filter criteria by combining the observed labels and pseudo labels to obtain a more balanced and less noisy subset for a robust model training. Extensive experiments demonstrate that our method can extract this class-balanced subset with clean labels, which brings effective performance gains for long-tailed classification with label noise.

Yuxiang Ge, Jionghao Cheng, Ruiquan Ge et al.

Reconstructing 3D visual stimuli from Electroencephalography (EEG) data holds significant potential for applications in Brain-Computer Interfaces (BCIs) and aiding individuals with communication disorders. Traditionally, efforts have focused on converting brain activity into 2D images, neglecting the translation of EEG data into 3D objects. This limitation is noteworthy, as the human brain inherently processes three-dimensional spatial information regardless of whether observing 2D images or the real world. The neural activities captured by EEG contain rich spatial information that is inevitably lost when reconstructing only 2D images, thus limiting its practical applications in BCI. The transition from EEG data to 3D object reconstruction faces considerable obstacles. These include the presence of extensive noise within EEG signals and a scarcity of datasets that include both EEG and 3D information, which complicates the extraction process of 3D visual data. Addressing this challenging task, we propose an innovative EEG encoder architecture that integrates a dual self-attention mechanism. We use a hybrid training strategy to train the EEG Encoder, which includes cross-attention, contrastive learning, and self-supervised learning techniques. Additionally, by employing stable diffusion as a prior distribution and utilizing Variational Score Distillation to train a neural radiation field, we successfully generate 3D objects with similar content and structure from EEG data.

Ridong Han, Chaohao Yang, Tao Peng et al.

Human-like large language models (LLMs), especially the most powerful and popular ones in OpenAI's GPT family, have proven to be very helpful for many natural language processing (NLP) related tasks. Therefore, various attempts have been made to apply LLMs to information extraction (IE), which is a fundamental NLP task that involves extracting information from unstructured plain text. To demonstrate the latest representative progress in LLMs' information extraction ability, we assess the information extraction ability of GPT-4 (the latest version of GPT at the time of writing this paper) from four perspectives: Performance, Evaluation Criteria, Robustness, and Error Types. Our results suggest a visible performance gap between GPT-4 and state-of-the-art (SOTA) IE methods. To alleviate this problem, considering the LLMs' human-like characteristics, we propose and analyze the effects of a series of simple prompt-based methods, which can be generalized to other LLMs and NLP tasks. Rich experiments show our methods' effectiveness and some of their remaining issues in improving GPT-4's information extraction ability.