Kean Ming Tan

Kean Ming Tan, Heather Battey, Wen-Xin Zhou

We address the problem of how to achieve optimal inference in distributed quantile regression without stringent scaling conditions. This is challenging due to the non-smooth nature of the quantile regression (QR) loss function, which invalidates the use of existing methodology. The difficulties are resolved through a double-smoothing approach that is applied to the local (at each data source) and global objective functions. Despite the reliance on a delicate combination of local and global smoothing parameters, the quantile regression model is fully parametric, thereby facilitating interpretation. In the low-dimensional regime, we establish a finite-sample theoretical framework for the sequentially defined distributed QR estimators. This reveals a trade-off between the communication cost and statistical error. We further discuss and compare several alternative confidence set constructions, based on inversion of Wald and score-type tests and resampling techniques, detailing an improvement that is effective for more extreme quantile coefficients. In high dimensions, a sparse framework is adopted, where the proposed doubly-smoothed objective function is complemented with an $\ell_1$-penalty. We show that the corresponding distributed penalized QR estimator achieves the global convergence rate after a near-constant number of communication rounds. A thorough simulation study further elucidates our findings.

Kean Ming Tan, Junwei Lu, Tong Zhang et al.

Neuroscientists have enjoyed much success in understanding brain functions by constructing brain connectivity networks using data collected under highly controlled experimental settings. However, these experimental settings bear little resemblance to our real-life experience in day-to-day interactions with the surroundings. To address this issue, neuroscientists have been measuring brain activity under natural viewing experiments in which the subjects are given continuous stimuli, such as watching a movie or listening to a story. The main challenge with this approach is that the measured signal consists of both the stimulus-induced signal, as well as intrinsic-neural and non-neuronal signals. By exploiting the experimental design, we propose to estimate stimulus-locked brain network by treating non-stimulus-induced signals as nuisance parameters. In many neuroscience applications, it is often important to identify brain regions that are connected to many other brain regions during cognitive process. We propose an inferential method to test whether the maximum degree of the estimated network is larger than a pre-specific number. We prove that the type I error can be controlled and that the power increases to one asymptotically. Simulation studies are conducted to assess the performance of our method. Finally, we analyze a functional magnetic resonance imaging dataset obtained under the Sherlock Holmes movie stimuli.

Kean Ming Tan, Qiang Sun, Daniela Witten

We propose robust sparse reduced rank regression for analyzing large and complex high-dimensional data with heavy-tailed random noise. The proposed method is based on a convex relaxation of a rank- and sparsity-constrained non-convex optimization problem, which is then solved using the alternating direction method of multipliers algorithm. We establish non-asymptotic estimation error bounds under both Frobenius and nuclear norms in the high-dimensional setting. This is a major contribution over existing results in reduced rank regression, which mainly focus on rank selection and prediction consistency. Our theoretical results quantify the tradeoff between heavy-tailedness of the random noise and statistical bias. For random noise with bounded $(1+δ)$th moment with $δ\in (0,1)$, the rate of convergence is a function of $δ$, and is slower than the sub-Gaussian-type deviation bounds; for random noise with bounded second moment, we obtain a rate of convergence as if sub-Gaussian noise were assumed. Furthermore, the transition between the two regimes is smooth. We illustrate the performance of the proposed method via extensive numerical studies and a data application.

Kean Ming Tan, Zhaoran Wang, Tong Zhang et al.

Sliced inverse regression is a popular tool for sufficient dimension reduction, which replaces covariates with a minimal set of their linear combinations without loss of information on the conditional distribution of the response given the covariates. The estimated linear combinations include all covariates, making results difficult to interpret and perhaps unnecessarily variable, particularly when the number of covariates is large. In this paper, we propose a convex formulation for fitting sparse sliced inverse regression in high dimensions. Our proposal estimates the subspace of the linear combinations of the covariates directly and performs variable selection simultaneously. We solve the resulting convex optimization problem via the linearized alternating direction methods of multiplier algorithm, and establish an upper bound on the subspace distance between the estimated and the true subspaces. Through numerical studies, we show that our proposal is able to identify the correct covariates in the high-dimensional setting.

Qiang Sun, Kean Ming Tan, Han Liu et al.

We consider the problem of learning high-dimensional Gaussian graphical models. The graphical lasso is one of the most popular methods for estimating Gaussian graphical models. However, it does not achieve the oracle rate of convergence. In this paper, we propose the graphical nonconvex optimization for optimal estimation in Gaussian graphical models, which is then approximated by a sequence of convex programs. Our proposal is computationally tractable and produces an estimator that achieves the oracle rate of convergence. The statistical error introduced by the sequential approximation using the convex programs are clearly demonstrated via a contraction property. The rate of convergence can be further improved using the notion of sparsity pattern. The proposed methodology is then extended to semiparametric graphical models. We show through numerical studies that the proposed estimator outperforms other popular methods for estimating Gaussian graphical models.

Kean Ming Tan, Zhaoran Wang, Han Liu et al.

Sparse generalized eigenvalue problem (GEP) plays a pivotal role in a large family of high-dimensional statistical models, including sparse Fisher's discriminant analysis, canonical correlation analysis, and sufficient dimension reduction. Sparse GEP involves solving a non-convex optimization problem. Most existing methods and theory in the context of specific statistical models that are special cases of the sparse GEP require restrictive structural assumptions on the input matrices. In this paper, we propose a two-stage computational framework to solve the sparse GEP. At the first stage, we solve a convex relaxation of the sparse GEP. Taking the solution as an initial value, we then exploit a nonconvex optimization perspective and propose the truncated Rayleigh flow method (Rifle) to estimate the leading generalized eigenvector. We show that Rifle converges linearly to a solution with the optimal statistical rate of convergence for many statistical models. Theoretically, our method significantly improves upon the existing literature by eliminating structural assumptions on the input matrices for both stages. To achieve this, our analysis involves two key ingredients: (i) a new analysis of the gradient based method on nonconvex objective functions, and (ii) a fine-grained characterization of the evolution of sparsity patterns along the solution path. Thorough numerical studies are provided to validate the theoretical results.

Lei Han, Kean Ming Tan, Ting Yang et al.

A major challenge for building statistical models in the big data era is that the available data volume far exceeds the computational capability. A common approach for solving this problem is to employ a subsampled dataset that can be handled by available computational resources. In this paper, we propose a general subsampling scheme for large-scale multi-class logistic regression and examine the variance of the resulting estimator. We show that asymptotically, the proposed method always achieves a smaller variance than that of the uniform random sampling. Moreover, when the classes are conditionally imbalanced, significant improvement over uniform sampling can be achieved. Empirical performance of the proposed method is compared to other methods on both simulated and real-world datasets, and these results match and confirm our theoretical analysis.

Kean Ming Tan, Noah Simon, Daniela Witten

We consider large-scale studies in which it is of interest to test a very large number of hypotheses, and then to estimate the effect sizes corresponding to the rejected hypotheses. For instance, this setting arises in the analysis of gene expression or DNA sequencing data. However, naive estimates of the effect sizes suffer from selection bias, i.e., some of the largest naive estimates are large due to chance alone. Many authors have proposed methods to reduce the effects of selection bias under the assumption that the naive estimates of the effect sizes are independent. Unfortunately, when the effect size estimates are dependent, these existing techniques can have very poor performance, and in practice there will often be dependence. We propose an estimator that adjusts for selection bias under a recently-proposed frequentist framework, without the independence assumption. We study some properties of the proposed estimator, and illustrate that it outperforms past proposals in a simulation study and on two gene expression data sets.

Kean Ming Tan, Palma London, Karthik Mohan et al.

We consider the problem of learning a high-dimensional graphical model in which certain hub nodes are highly-connected to many other nodes. Many authors have studied the use of an l1 penalty in order to learn a sparse graph in high-dimensional setting. However, the l1 penalty implicitly assumes that each edge is equally likely and independent of all other edges. We propose a general framework to accommodate more realistic networks with hub nodes, using a convex formulation that involves a row-column overlap norm penalty. We apply this general framework to three widely-used probabilistic graphical models: the Gaussian graphical model, the covariance graph model, and the binary Ising model. An alternating direction method of multipliers algorithm is used to solve the corresponding convex optimization problems. On synthetic data, we demonstrate that our proposed framework outperforms competitors that do not explicitly model hub nodes. We illustrate our proposal on a webpage data set and a gene expression data set.

Kean Ming Tan, Daniela Witten, Ali Shojaie

We consider the task of estimating a Gaussian graphical model in the high-dimensional setting. The graphical lasso, which involves maximizing the Gaussian log likelihood subject to an l1 penalty, is a well-studied approach for this task. We begin by introducing a surprising connection between the graphical lasso and hierarchical clustering: the graphical lasso in effect performs a two-step procedure, in which (1) single linkage hierarchical clustering is performed on the variables in order to identify connected components, and then (2) an l1-penalized log likelihood is maximized on the subset of variables within each connected component. In other words, the graphical lasso determines the connected components of the estimated network via single linkage clustering. Unfortunately, single linkage clustering is known to perform poorly in certain settings. Therefore, we propose the cluster graphical lasso, which involves clustering the features using an alternative to single linkage clustering, and then performing the graphical lasso on the subset of variables within each cluster. We establish model selection consistency for this technique, and demonstrate its improved performance relative to the graphical lasso in a simulation study, as well as in applications to an equities data set, a university webpage data set, and a gene expression data set.