Temporal Gaussian Copula For Clinical Multivariate Time Series Data ImputationYe Su, Hezhe Qiao, Di Wu et al.
The imputation of the Multivariate time series (MTS) is particularly challenging since the MTS typically contains irregular patterns of missing values due to various factors such as instrument failures, interference from irrelevant data, and privacy regulations. Existing statistical methods and deep learning methods have shown promising results in time series imputation. In this paper, we propose a Temporal Gaussian Copula Model (TGC) for three-order MTS imputation. The key idea is to leverage the Gaussian Copula to explore the cross-variable and temporal relationships based on the latent Gaussian representation. Subsequently, we employ an Expectation-Maximization (EM) algorithm to improve robustness in managing data with varying missing rates. Comprehensive experiments were conducted on three real-world MTS datasets. The results demonstrate that our TGC substantially outperforms the state-of-the-art imputation methods. Additionally, the TGC model exhibits stronger robustness to the varying missing ratios in the test dataset. Our code is available at https://github.com/MVL-Lab/TGC-MTS.
4.1LGAug 12, 2025
Toward Generalist Semi-supervised Regression via Decoupled Representation DistillationYe Su, Hezhe Qiao, Wei Huang et al.
Semi-supervised regression (SSR), which aims to predict continuous scores of samples while reducing reliance on a large amount of labeled data, has recently received considerable attention across various applications, including computer vision, natural language processing, and audio and medical analysis. Existing semi-supervised methods typically apply consistency regularization on the general regression task by generating pseudo-labels. However, these methods heavily rely on the quality of pseudo-labels, and direct regression fails to learn the label distribution and can easily lead to overfitting. To address these challenges, we introduce an end-to-end Decoupled Representation distillation framework (DRILL) which is specially designed for the semi-supervised regression task where we transform the general regression task into a Discrete Distribution Estimation (DDE) task over multiple buckets to better capture the underlying label distribution and mitigate the risk of overfitting associated with direct regression. Then we employ the Decoupled Distribution Alignment (DDA) to align the target bucket and non-target bucket between teacher and student on the distribution of buckets, encouraging the student to learn more robust and generalized knowledge from the teacher. Extensive experiments conducted on datasets from diverse domains demonstrate that the proposed DRILL has strong generalization and outperforms the competing methods.
4.1LGApr 7, 2025
Sub-Clustering for Class Distance Recalculation in Long-Tailed Drug ClassificationYujia Su, Xinjie Li, Lionel Z. Wang
In the real world, long-tailed data distributions are prevalent, making it challenging for models to effectively learn and classify tail classes. However, we discover that in the field of drug chemistry, certain tail classes exhibit higher identifiability during training due to their unique molecular structural features, a finding that significantly contrasts with the conventional understanding that tail classes are generally difficult to identify. Existing imbalance learning methods, such as resampling and cost-sensitive reweighting, overly rely on sample quantity priors, causing models to excessively focus on tail classes at the expense of head class performance. To address this issue, we propose a novel method that breaks away from the traditional static evaluation paradigm based on sample size. Instead, we establish a dynamical inter-class separability metric using feature distances between different classes. Specifically, we employ a sub-clustering contrastive learning approach to thoroughly learn the embedding features of each class, and we dynamically compute the distances between class embeddings to capture the relative positional evolution of samples from different classes in the feature space, thereby rebalancing the weights of the classification loss function. We conducted experiments on multiple existing long-tailed drug datasets and achieved competitive results by improving the accuracy of tail classes without compromising the performance of dominant classes.