M. Wolf

Md Abdul Kadir, Hasan Md Tusfiqur Alam, Pascale Maul et al.

Image annotation is one of the most essential tasks for guaranteeing proper treatment for patients and tracking progress over the course of therapy in the field of medical imaging and disease diagnosis. However, manually annotating a lot of 2D and 3D imaging data can be extremely tedious. Deep Learning (DL) based segmentation algorithms have completely transformed this process and made it possible to automate image segmentation. By accurately segmenting medical images, these algorithms can greatly minimize the time and effort necessary for manual annotation. Additionally, by incorporating Active Learning (AL) methods, these segmentation algorithms can perform far more effectively with a smaller amount of ground truth data. We introduce MedDeepCyleAL, an end-to-end framework implementing the complete AL cycle. It provides researchers with the flexibility to choose the type of deep learning model they wish to employ and includes an annotation tool that supports the classification and segmentation of medical images. The user-friendly interface allows for easy alteration of the AL and DL model settings through a configuration file, requiring no prior programming experience. While MedDeepCyleAL can be applied to any kind of image data, we have specifically applied it to ophthalmology data in this project.

F. Wick, U. Kerzel, M. Hahn et al.

Demand forecasting is a central component of the replenishment process for retailers, as it provides crucial input for subsequent decision making like ordering processes. In contrast to point estimates, such as the conditional mean of the underlying probability distribution, or confidence intervals, forecasting complete probability density functions allows to investigate the impact on operational metrics, which are important to define the business strategy, over the full range of the expected demand. Whereas metrics evaluating point estimates are widely used, methods for assessing the accuracy of predicted distributions are rare, and this work proposes new techniques for both qualitative and quantitative evaluation methods. Using the supervised machine learning method "Cyclic Boosting", complete individual probability density functions can be predicted such that each prediction is fully explainable. This is of particular importance for practitioners, as it allows to avoid "black-box" models and understand the contributing factors for each individual prediction. Another crucial aspect in terms of both explainability and generalizability of demand forecasting methods is the limitation of the influence of temporal confounding, which is prevalent in most state of the art approaches.