M M Hassan Mahmud

Ruth Amey, Muhammad Arifur Rahman, Taha Osman et al.

Federated learning has emerged as a potential solution to privacy concerns associated with using sensitive health data for training predictive models, particularly in personalised cancer care. This research investigates whether federated learning can support the development of robust models for predicting tumour progression in breast cancer patients while addressing four critical deployment pillars: transparency, scalability, security, and fairness. This study evaluates a federated learning framework using multimodal data, including clinical information, tumour characteristics, biomarker data, and patient demographics, alongside medical imaging data such as MRI scans, to model changes in tumour characteristics over time. The performance of the federated approach was compared with that of a centralised model trained on aggregated data. The report then further examines strategies to enhance secure model updates, maintain performance across patient subgroups, and support scalability across institutions. The findings assess whether federated learning can achieve predictive performance comparable to centralised learning while preserving data locality. These results contribute to understanding the feasibility of privacy-preserving, multimodal predictive modelling and support future applications such as digital twins to assist clinicians and patients in personalised treatment planning.

Akarsh K Nair, Muhammad Arifur Rahman, Nicholas Shopland et al.

Federated learning (FL) offers a promising approach to privacy-preserving clinical risk prediction, but its deployment remains limited by restricted data sharing, client heterogeneity, class imbalance, and the lack of realistic tabular electronic health record (EHR) benchmarks. Synthetic data generation may alleviate data scarcity, yet its integration with federated optimisation has received limited systematic study. We propose SynPre-FL, a unified framework combining high-fidelity synthetic EHR generation with synthetic-pretrained FL for robust prediction under non-IID conditions. A latent autoencoder-diffusion model generates privacy-preserving synthetic cohorts, which are used to warm-start federated training. This pretraining is followed by heterogeneity-aware optimisation using class-balanced local objectives, proximal regularisation, and adaptive server aggregation. Post-hoc calibration and federated-safe explainability support reliable and interpretable risk estimates. Experiments show that the synthetic generator preserves univariate, bivariate, and multivariate structure while protecting against membership-inference and reconstruction attacks. The generated data achieve strong downstream utility under TSTR, TRTS, and model-based evaluations. Across federated settings with 5, 10, and 15 heterogeneous clients, SynPre-FL consistently improves robustness and scalability over baseline methods, especially under severe non-IID fragmentation. Calibration improves probability reliability, while SHAP analysis produces stable and clinically coherent feature attributions across federation sizes. SynPre-FL therefore provides a practical and reproducible framework for combining synthetic data with FL to enable privacy-aware, interpretable, and robust clinical prediction from distributed tabular EHR data.

Daniel Goldsmith, M M Hassan Mahmud

Quantum machine learning (QML) is a promising early use case for quantum computing. There has been progress in the last five years from theoretical studies and numerical simulations to proof of concepts. Use cases demonstrated on contemporary quantum devices include classifying medical images and items from the Iris dataset, classifying and generating handwritten images, toxicity screening, and learning a probability distribution. Potential benefits of QML include faster training and identification of feature maps not found classically. Although, these examples lack the scale for commercial exploitation, and it may be several years before QML algorithms replace the classical solutions, QML is an exciting area. This article is written for those who already have a sound knowledge of quantum computing and now wish to gain a basic overview of the terminology and some applications of classical machine learning ready to study quantum machine learning. The reader will already understand the relevant relevant linear algebra, including Hilbert spaces, a vector space with an inner product.

Nguyen Kim Hai Bui, Md. Easin Arafat, Tamás Gábor Orosz et al.

Despite remarkable progress in machine translation, Vision Language Models (VLMs) struggle on historical manuscripts, a domain that stresses core Natural Language Processing (NLP) capabilities: low-resource transliteration, archaic vocabulary, and noisy input signals. We present a systematic framework for evaluating the full image-to-translation pipeline on medieval Latin manuscripts, a setting in which scribal shorthand, ligatures, and parchment degradation expose failure modes that are invisible in clean-text benchmarks. Benchmarking on the CATMuS Latin dataset reveals a specialization gap: domain-specific Optical Character Recognition (OCR) models reduce character error rate by up to 4.3$\times$ compared to general-purpose VLMs, despite operating at orders of magnitude fewer parameters. We introduce the Interpres-Parallel-Corpus (IPC), a novel dataset comprising 1,383 aligned manuscript image lines, transcriptions, and expert translations, the first of its kind for medieval Latin. Our experiments uncover a complexity paradox: the simplest pipeline, a specialized OCR model feeding directly into a VLM, outperforms all multi-component variants. Adding retrieval-augmented generation (RAG) or post-OCR correction introduces prompt saturation and error propagation that degrade aggregate translation quality. These findings offer both a new benchmark and practical guidance for deploying translation systems in low-resource historical settings.