Wing Yan Li

Zi Wang, Mingkai Huang, Zhang Shi et al.

Multimodal cardiovascular magnetic resonance (CMR) imaging provides comprehensive and non-invasive insights into cardiovascular disease (CVD) diagnosis and underlying mechanisms. Despite decades of advancements, its widespread clinical adoption remains constrained by prolonged scan times and heterogeneity across medical environments. This underscores the urgent need for a generalist reconstruction foundation model for ultra-fast CMR imaging, one capable of adapting across diverse imaging scenarios and serving as the essential substrate for all downstream analyses. To enable this goal, we curate MMCMR-427K, the largest and most comprehensive multimodal CMR k-space database to date, comprising 427,465 multi-coil k-space data paired with structured metadata across 13 international centers, 12 CMR modalities, 15 scanners, and 17 CVD categories in populations across three continents. Building on this unprecedented resource, we introduce CardioMM, a generalist reconstruction foundation model capable of dynamically adapting to heterogeneous fast CMR imaging scenarios. CardioMM unifies semantic contextual understanding with physics-informed data consistency to deliver robust reconstructions across varied scanners, protocols, and patient presentations. Comprehensive evaluations demonstrate that CardioMM achieves state-of-the-art performance in the internal centers and exhibits strong zero-shot generalization to unseen external settings. Even at imaging acceleration up to 24x, CardioMM reliably preserves key cardiac phenotypes, quantitative myocardial biomarkers, and diagnostic image quality, enabling a substantial increase in CMR examination throughput without compromising clinical integrity. Together, our open-access MMCMR-427K database and CardioMM framework establish a scalable pathway toward high-throughput, high-quality, and clinically accessible cardiovascular imaging.

Mingyu Sun, Xiao Zhang, Shen Qu et al.

Providing lossless inference services of LLMs on edge devices remains challenging, especially given the extremely tight memory budgets. The existing offloading techniques inevitably introduce numerous loading bubbles, which further inflate the end-to-end latency of the entire inference pipeline. Meanwhile, dynamically fluctuating network bandwidth and diverse user request patterns pose additional obstacles to efficient lossless inference on edge devices. To address this, we propose LOIP, a collaborative lossless LLM inference system that employs an offloading-based interleaved pipeline parallelism to better overlap model offloading with computing and communicating. Specifically, LOIP first constructs an offloading-aware cost model to characterize inference latency and memory overhead under heterogeneous device capabilities and limited bandwidth. Based on this cost model, LOIP develops a fine-grained allocation scheduler that determines latency-efficient layer partitions across devices while explicitly accounting for offloading overhead, along with a unified memory architecture (UMA)-aware loading optimization using customized CUDA operators to reduce runtime loading overhead. LOIP further designs an online memory adaptation strategy to handle the increasing KV cache pressure and dynamic bandwidth fluctuations during inference. We implement LOIP with 2500+ lines of Python and 500+ lines of C++/CUDA code, and deploy it on five heterogeneous NVIDIA Jetson edge devices for lossless collaborative inference of LLaMA3.3-70B-Instruct. Extensive experiments demonstrate that LOIP achieves 8.8$\times$$\sim$20.3$\times$ speedups over the SOTA baselines under different bandwidth conditions and request patterns without compromising model accuracy.