Wenzhi Deng

Baochen Fu, Wenzhi Deng, Baihao Jin et al.

Optical coherence tomography (OCT) imaging is essential for the diagnosis and treatment of retinal diseases. Although multimodal large language models (MLLMs) have demonstrated considerable potential in medical image analysis, existing benchmarks largely reduce OCT understanding to coarse-grained disease classification or isolated visual question answering, leaving the complete cognitive process from visual perception to clinical reasoning insufficiently evaluated. To address this limitation, we introduce OCT-Bench, a comprehensive benchmark dedicated to OCT image understanding. OCT-Bench comprises 10,076 high-quality multiple-choice questions constructed from 4,137 OCT images across seven public datasets. Following the real-world clinical interpretation workflow, we establish a hierarchical capability taxonomy consisting of 20 fine-grained tasks across three dimensions: Perception, Cognition, and Reasoning. These tasks cover a broad range of capabilities, including imaging attributes, retinal anatomy, lesion characteristics, spatial relationships, disease assessment, therapeutic decision-making, and prognostic management. We systematically evaluate 20 representative MLLMs, including proprietary models, open-source general-purpose models, and medical-domain models. Experimental results demonstrate that current models remain substantially short of reliable OCT understanding. Moreover, neither medical-domain adaptation nor increased model scale consistently improves performance across capability levels. OCT-Bench enables comprehensive and fine-grained evaluation of MLLMs, providing a foundation for identifying capability bottlenecks and advancing clinically grounded OCT understanding.

Baochen Fu, Yuntao Du, Cheng Chang et al.

As real-world knowledge continues to evolve, the parametric knowledge acquired by multimodal models during pretraining becomes increasingly difficult to remain consistent with real-world knowledge. Existing research on multimodal knowledge updating focuses only on learning previously unknown knowledge, while overlooking the need to update knowledge that the model has already mastered but that later changes; moreover, evaluation is limited to the same modality, lacking a systematic analysis of cross-modal consistency. To address these issues, this paper proposes MMKU-Bench, a comprehensive evaluation benchmark for multimodal knowledge updating, which contains over 25k knowledge instances and more than 49k images, covering two scenarios, updated knowledge and unknown knowledge, thereby enabling comparative analysis of learning across different knowledge types. On this benchmark, we evaluate a variety of representative approaches, including supervised fine-tuning (SFT), reinforcement learning from human feedback (RLHF), and knowledge editing (KE). Experimental results show that SFT and RLHF are prone to catastrophic forgetting, while KE better preserve general capabilities but exhibit clear limitations in continual updating. Overall, MMKU-Bench provides a reliable and comprehensive evaluation benchmark for multimodal knowledge updating, advancing progress in this field.