Zhuo Chen (135585)

Zhuo Chen, Shawn Young, Lijian Xu

The application of large vision-language models to computational pathology holds great promise for diagnostic assistants but faces a critical computational bottleneck: the gigapixel scale of Whole Slide Images (WSIs). A single WSI typically contains over 105 patches, creating sequence lengths that exceed the constraints of standard Transformer architectures. Existing solutions often resort to spatial sampling, which risks discarding diagnostically critical evidence. To address this, we propose TC-SSA (Token Compression via Semantic Slot Aggregation), a learnable token compression framework that aggregates patch features into a fixed number of semantic slots. A gated routing module assigns patches to slots using sparse Top-2 routing, followed by weighted aggregation, enabling global slide coverage under a strict token budget. The resulting representation retains diagnostically relevant information while reducing the number of visual tokens to 1.7% of the original sequence. On the SlideBench(TCGA), our model achieves 78.34% overall accuracy and 77.14% on the diagnosis subset, outperforming sampling-based baselines under comparable token budgets. The method also generalizes to MIL classification, reaching AUC of 95.83% on TCGA-BRCA, 98.27% on TCGA-NSCLC and 79.80% on PANDA. These results suggest that learnable semantic aggregation provides an effective trade-off between efficiency and diagnostic performance for gigapixel pathology reasoning.

Zhen Zhou, Jian Liu, Biwen Lei et al.

Reinforcement learning (RL) has demonstrated remarkable success in text and image generation, yet its potential in 3D generation remains largely unexplored. Existing attempts typically rely on offline direct preference optimization (DPO) method, which suffers from low training efficiency and limited generalization. In this work, we aim to enhance both the training efficiency and generation quality of RL in 3D mesh generation. Specifically, (1) we design the first asynchronous online RL framework tailored for 3D mesh generation post-training efficiency improvement, which is 3.75$\times$ faster than synchronous RL. (2) We propose Advantage-guided Ranking Preference Optimization (ARPO), a novel RL algorithm that achieves a better trade-off between training efficiency and generalization than current RL algorithms designed for 3D mesh generation, such as DPO and group relative policy optimization (GRPO). (3) Based on asynchronous ARPO, we propose Mesh-Pro, which additionally introduces a novel diagonal-aware mixed triangular-quadrilateral tokenization for mesh representation and a ray-based reward for geometric integrity. Mesh-Pro achieves state-of-the-art performance on artistic and dense meshes.