Yejin Choi

Shangbin Feng, Yike Wang, Weijia Shi et al. · berkeley

Humanity is a mosaic of multifaceted talents and needs, and any truly intelligent AI must reflect that richness. Yet the LLMs used by all are built by the few -- a centralized market of monolithic AI models structurally ill-suited to capture the diversity of human knowledge, reasoning, and values. Here we introduce scaling participation, a new paradigm in which modular AI systems are built from the bottom up through the contributions of diverse stakeholders. Participants contribute small models trained on their own interests and priorities; these models then collaborate in modular frameworks as compositional AI systems. Participatory AI systems outperform monolithic LLMs by up to 15.4% across 15 tasks, such as reasoning and factuality, surpassing models larger than all contributed components combined. Further experiments show that participatory AI systems benefit from contributor diversity, substantially improve on each contributor's original priorities, and exhibit emergent capabilities that allow them to solve over 15% of problems where all individual models fail. Scaling participation provides a technical foundation for transitioning from the monolithic status quo toward an open, bottom-up, and collaborative AI future.

Fang Wu, Shuting Jin, Xiangru Tang et al.

Protein function is largely determined by molecular surface geometry and physicochemical complementarity, yet most protein design methods condition only on backbone structure. We introduce SurfDesign, a surface-conditioned protein design framework that models molecular surfaces as continuous geometric manifolds and integrates them with pretrained protein language models. SurfDesign employs surface-based equivariant message passing to capture surface normals, curvature, and directional geometry, together with a parameter-efficient fine-tuning strategy. Focusing on functional protein design, we show that SurfDesign consistently outperforms prior surface-conditioned and backbone-only methods on de novo binder and enzyme design benchmarks. We also report strong performance on inverse-folding benchmarks as a diagnostic of structural compatibility. Our results highlight manifold-aware surface representations as a principled foundation for functional protein and enzyme design. Code is available at https://github.com/smiles724/SurfDesign.