Ye Yuan

Liuyun Jiang, Yanchao Zhang, Jinyue Guo et al.

Establishing large-scale, high-resolution neural connectivity maps is fundamental to elucidating the structural basis of brain function. However, when processing terabyte- or petabyte-scale electron microscopy data, over-segmentation inherent in automated reconstruction algorithms remains a critical bottleneck, requiring extensive manual proofreading spanning person-years. To alleviate the heavy reliance on annotated data and the limited flexibility of conventional tracing methods, we propose a training-free, targeted neuron tracing framework. Specifically, we introduce a skeleton-guided Heuristic Spatial Search paradigm that leverages geometric priors to iteratively reconstruct neuronal morphologies through a probing-verification cycle. To achieve robust zero-shot semantic verification, we further develop a Dimension-Aware Semantic Verification strategy built upon the foundation model NeuroSAM 2. This strategy resolves intra-slice splits via Planar Ensemble Consensus and inter-slice splits via Axial Spatio-Temporal Propagation. Notably, we integrate the proposed workflow into the Neuroglancer visualization platform, enabling an interactive human-in-the-loop proofreading system. Experimental results demonstrate that the proposed method outperforms supervised baselines and reduces manual proofreading time by 33.4%. The source code is publicly available at https://github.com/HeadLiuYun/Probe-EM.

Yi Lan, Ye Yuan

Graph Neural Networks (GNNs) have achieved remarkable performance in graph representation learning, yet their inherent vulnerability to adversarial attacks poses severe security risks. Especially, black-box node injection attacks have become a major threat to GNNs since they inject malicious nodes without altering the original graph topology. However, they typically decouple the generation of malicious node features and edge connections, thereby resulting in suboptimal attack efficacy under stringent budgets. To address this critical issue, this study proposes a novel Target-aware Interaction-guided Reinforcement learning for Black-box node injection Attacks on GNNs (TIRBA), which formulates the attack as a Markov Decision Process and jointly optimizes node feature generation and edge construction in a heterogeneous action space. Firstly, TIRBA designs a target-aware interaction encoder to fuse information of node features and edges. Further, it introduces a class-center guidance mechanism to utilize prior class distribution information, thereby guiding efficient exploration of the high-dimensional feature space. Finally, a topology difference-aware state value evaluation is adopted to explicitly capture local structural anomalies caused by injected nodes, thereby stabilizing the reinforcement learning training process. Experimental results demonstrate that the proposed TIRBA significantly outperforms state-of-the-art black-box node injection attack methods.

Fuyan Ou, Yulin Hu, Ye Yuan

Heterogeneous Graph Neural Networks (HGNNs) have exhibited remarkable efficacy in modeling complex systems with multiple types of nodes and relations, yet their training on large-scale heterogeneous graphs remains computationally prohibitive. Although graph condensation methods can effectively improve learning efficiency on large-scale graphs, existing condensation processes are mainly designed for homogeneous graphs and typically rely on computationally expensive gradient matching or bilevel optimization paradigms, rendering them impractical for heterogeneous settings. To address these limitations, we propose HGC-RC, a simple yet effective role-aware heterogeneous graph condensation framework. Specifically, HGC-RC first extracts semantically enhanced node embeddings via lightweight propagation. It then introduces a role-aware hybrid clustering strategy consisting of class-partitioned clustering for labeled target nodes to preserve class distributions and unsupervised type-wise clustering for non-target nodes to retain critical cross-type connectivity. Finally, a compact heterogeneous graph is efficiently reconstructed based on the resulting cluster assignments. Extensive experiments demonstrate that HGC-RC outperforms state-of-the-art baselines, offering a practical pathway to accelerate HGNN training on large-scale heterogeneous graphs without sacrificing task performance