Jie Liu

Ping Chen, Xiangming Wang, Yongyong Chen et al.

Image demosaicing reconstructs a full-color image from incomplete color measurements produced by a sensor covered with a color filter array (CFA). Most existing methods formulate demosaicing as pixel-level reconstruction and mainly rely on local textures, cross-channel correlations, and low-level image statistics. Our core insight is that reconstruction and visual understanding can be viewed as complementary views of shared scene structure: both are grounded in the same underlying physical world, and therefore the structural and physical information inferred from an image should remain consistent across the two tasks. We instantiate this idea with instance segmentation and propose \emph{SegDem}, a cross-task decoder representation transfer framework for demosaicing. SegDem first learns region- and boundary-aware representations through instance-aware structural pretraining and then transfers the decoder to RAW-conditioned reconstruction. Segmentation- and demosaicing-conditioned features are further anchored to a shared frozen DINOv2 representation space to preserve structural organization across tasks. We instantiate SegDem with convolutional, Transformer-based, and state-space backbones for unified Single- and Quad-Bayer demosaicing. Extensive experiments on synthetic, external, and challenging datasets demonstrate consistent improvements across different architectures and CFA layouts.

Xin Luo, Yicheng Tao, Haoxuan Zeng et al.

Spatial transcriptomics can resolve gene expression at single-cell resolution, but it is costly, limited to targeted panels of a few hundred to a few thousand genes, and applicable to only a small number of samples. H&E imaging, by contrast, is cheap and collected routinely at scale. This makes predicting single-cell expression directly from morphology a practical way to bring molecular analysis to large tissue archives. We therefore present VOICE, a multimodal foundation model that predicts single-cell gene expression from H&E images using paired Xenium data. VOICE first aligns cell centered H&E morphology from a pathology foundation model with single-cell expression embeddings from a transcriptome foundation model, trained using contrastive learning over 23 million cells. Next it predicts expression through two branches. One branch directly regresses expression from morphology. The other branch retrieves measured expression from similar reference cells, recovering genes that do not have morphological signal. Because genes vary in morphological predictability, VOICE fuses the two branches with a per-gene weight. After training, VOICE generalizes to heldout patients, slides, and partially overlapping gene panels from Xenium, and it consistently outperforms prior single-cell expression prediction methods on seven metrics.