Modeling and simulation of Ran-mediated nuclear import
arXiv:0907.09741.2
Originality Synthesis-oriented
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For cell biology researchers, this model provides a more comprehensive understanding of nuclear transport mechanisms.
The paper presents a mathematical model of Ran-driven nuclear import that is the first to account for active transport along cytoplasmic microtubules, with simulations reproducing experimental behavior.
We present here a detailed description of the model of ran-driven nuclear transduction in living cells to be published elswere. The mathematical model presented is the first to account for the active transport of molecules along the cytoplasmic microtubules. All parameters entering the models are thoroughly discussed. The simulations reproduce the behavior observed experimentally.