A Novel Approach for Protein Structure Prediction
This work addresses protein structure prediction, a key problem in bioinformatics, but appears incremental as it builds on existing methods like HMMs and ANNs without introducing a new paradigm.
The study tackled protein structure prediction by comparing two hidden Markov models, one with secondary structures as hidden states and sequences as observed, and the other with sequences as hidden states and structures as observed, finding that the first model had higher efficiency, which was cross-validated using an artificial neural network.
The idea of this project is to study the protein structure and sequence relationship using the hidden markov model and artificial neural network. In this context we have assumed two hidden markov models. In first model we have taken protein secondary structures as hidden and protein sequences as observed. In second model we have taken protein sequences as hidden and protein structures as observed. The efficiencies for both the hidden markov models have been calculated. The results show that the efficiencies of first model is greater that the second one .These efficiencies are cross validated using artificial neural network. This signifies the importance of protein secondary structures as the main hidden controlling factors due to which we observe a particular amino acid sequence. This also signifies that protein secondary structure is more conserved in comparison to amino acid sequence.