Deep Learning for Identifying Metastatic Breast Cancer
This addresses the problem of improving diagnostic accuracy for metastatic breast cancer detection in pathology, representing a strong specific gain rather than incremental.
The paper tackled the problem of automated detection of metastatic breast cancer in whole slide images, achieving an AUC of 0.925 for classification and 0.7051 for localization, and combining with a pathologist's diagnoses reduced human error by approximately 85%.
The International Symposium on Biomedical Imaging (ISBI) held a grand challenge to evaluate computational systems for the automated detection of metastatic breast cancer in whole slide images of sentinel lymph node biopsies. Our team won both competitions in the grand challenge, obtaining an area under the receiver operating curve (AUC) of 0.925 for the task of whole slide image classification and a score of 0.7051 for the tumor localization task. A pathologist independently reviewed the same images, obtaining a whole slide image classification AUC of 0.966 and a tumor localization score of 0.733. Combining our deep learning system's predictions with the human pathologist's diagnoses increased the pathologist's AUC to 0.995, representing an approximately 85 percent reduction in human error rate. These results demonstrate the power of using deep learning to produce significant improvements in the accuracy of pathological diagnoses.