Input-Output Non-Linear Dynamical Systems applied to Physiological Condition Monitoring
This addresses monitoring physiological conditions in ICU patients, offering an incremental improvement by reducing reliance on expert knowledge.
The paper tackled modeling the effect of Propofol drug infusions on patient vital signs in ICUs, showing that their non-linear dynamical system approach provides significant performance improvements compared to existing PK/PD methods without needing expert physiological knowledge.
We present a non-linear dynamical system for modelling the effect of drug infusions on the vital signs of patients admitted in Intensive Care Units (ICUs). More specifically we are interested in modelling the effect of a widely used anaesthetic drug (Propofol) on a patient's monitored depth of anaesthesia and haemodynamics. We compare our approach with one from the Pharmacokinetics/Pharmacodynamics (PK/PD) literature and show that we can provide significant improvements in performance without requiring the incorporation of expert physiological knowledge in our system.