Encoding the Local Connectivity Patterns of fMRI for Cognitive State Classification
This work addresses the challenge of interpreting brain activity for cognitive state classification, but it is incremental as it applies existing encoding techniques to fMRI data.
The authors tackled the problem of classifying cognitive states from fMRI data by encoding local connectivity patterns using Fisher Vectors, VLAD, and BoW methods, achieving improved classification performance with Fisher Vectors over other representations on the Human Connectome Project dataset.
In this work, we propose a novel framework to encode the local connectivity patterns of brain, using Fisher Vectors (FV), Vector of Locally Aggregated Descriptors (VLAD) and Bag-of-Words (BoW) methods. We first obtain local descriptors, called Mesh Arc Descriptors (MADs) from fMRI data, by forming local meshes around anatomical regions, and estimating their relationship within a neighborhood. Then, we extract a dictionary of relationships, called \textit{brain connectivity dictionary} by fitting a generative Gaussian mixture model (GMM) to a set of MADs, and selecting the codewords at the mean of each component of the mixture. Codewords represent the connectivity patterns among anatomical regions. We also encode MADs by VLAD and BoW methods using the k-Means clustering. We classify the cognitive states of Human Connectome Project (HCP) task fMRI dataset, where we train support vector machines (SVM) by the encoded MADs. Results demonstrate that, FV encoding of MADs can be successfully employed for classification of cognitive tasks, and outperform the VLAD and BoW representations. Moreover, we identify the significant Gaussians in mixture models by computing energy of their corresponding FV parts, and analyze their effect on classification accuracy. Finally, we suggest a new method to visualize the codewords of brain connectivity dictionary.