Control Strategy for Anaesthetic Drug Dosage with Interaction Among Human Physiological Organs Using Optimal Fractional Order PID Controller
For anesthesiologists and biomedical engineers, it offers a more efficient and robust control strategy for drug delivery, though it is an incremental application of existing control methods.
This paper proposes an optimal fractional order PID controller for anaesthetic drug dosage in a multi-organ physiological model, achieving reduced drug infusion and high robustness to ±50% parametric uncertainty.
In this paper, an efficient control strategy for physiological interaction based anaesthetic drug infusion model is explored using the fractional order (FO) proportional integral derivative (PID) controllers. The dynamic model is composed of several human organs by considering the brain response to the anaesthetic drug as output and the drug infusion rate as the control input. Particle Swarm Optimisation (PSO) is employed to obtain the optimal set of parameters for PID/FOPID controller structures. With the proposed FOPID control scheme much less amount of drug-infusion system can be designed to attain a specific anaesthetic target and also shows high robustness for +/-50% parametric uncertainty in the patient's brain model.