Idea density for predicting Alzheimer's disease from transcribed speech
This work addresses Alzheimer's disease diagnosis using speech analysis, offering incremental improvements in automated classification.
The paper tackled predicting Alzheimer's disease from speech by developing DEPID, a dependency-based method for computing propositional idea density, and compared it with semantic idea density on two datasets. Results showed that adding PID improved F-score by 1.7 on a normative dataset, and combining features achieved an F-score of 84.8 on a free-topic dataset.
Idea Density (ID) measures the rate at which ideas or elementary predications are expressed in an utterance or in a text. Lower ID is found to be associated with an increased risk of developing Alzheimer's disease (AD) (Snowdon et al., 1996; Engelman et al., 2010). ID has been used in two different versions: propositional idea density (PID) counts the expressed ideas and can be applied to any text while semantic idea density (SID) counts pre-defined information content units and is naturally more applicable to normative domains, such as picture description tasks. In this paper, we develop DEPID, a novel dependency-based method for computing PID, and its version DEPID-R that enables to exclude repeating ideas---a feature characteristic to AD speech. We conduct the first comparison of automatically extracted PID and SID in the diagnostic classification task on two different AD datasets covering both closed-topic and free-recall domains. While SID performs better on the normative dataset, adding PID leads to a small but significant improvement (+1.7 F-score). On the free-topic dataset, PID performs better than SID as expected (77.6 vs 72.3 in F-score) but adding the features derived from the word embedding clustering underlying the automatic SID increases the results considerably, leading to an F-score of 84.8.