Simulation of left ventricle fluid dynamics with mitral regurgitation from magnetic resonance images with fictitious elastic structure regularization
This work offers a new modeling framework for studying cardiac fluid dynamics, particularly mitral regurgitation, which could aid in clinical diagnosis and treatment planning for heart disease patients.
The paper introduces a novel image-driven computational model for left ventricle fluid dynamics that uses a fictitious elastic structure to impose ventricular motion and includes mitral valve models with regurgitation. The approach enables seamless simulation of isovolumic phases and provides quantitative insights into cardiac flow phenomena not visible with standard imaging.
Computer modeling can provide quantitative insight into cardiac fluid dynamics phenomena that are not evident from standard imaging tools. We propose a new approach to modeling left ventricle fluid dynamics based on an image-driven model-based description of ventricular motion. In this approach, the end-diastolic geometry and time-dependent deformation of the left ventricle cavity are obtained from cardiac magnetic resonance images and a fictitious elastic structure is used to impose the contractile behavior of the left ventricle. This allows seamless treatment of the isovolumic phases. Besides the ventricular motion, the intracavitary fluid dynamics is controlled by the mitral valve. Three different mitral valve models are included in the simulation: an idealized diode (with or without regurgitation) and a lumped parameter model accounting for the opening dynamics of the valve and including regurgitation.