Convergence of a Finite-Volume Scheme for a Degenerate Cross-Diffusion Model for Ion Transport
Provides rigorous convergence analysis for a challenging degenerate cross-diffusion system relevant to biological ion transport, but the method is an extension of existing techniques.
The paper analyzes a finite-volume scheme for a degenerate cross-diffusion ion transport model, proving existence, uniqueness, and convergence of discrete solutions, with numerical simulations indicating first-order accuracy.
An implicit Euler finite-volume scheme for a degenerate cross-diffusion system describing the ion transport through biological membranes is analyzed. The strongly coupled equations for the ion concentrations include drift terms involving the electric potential, which is coupled to the concentrations through the Poisson equation. The cross-diffusion system possesses a formal gradient-flow structure revealing nonstandard degen-eracies, which lead to considerable mathematical difficulties. The finite-volume scheme is based on two-point flux approximations with "double" upwind mobilities. It preserves the structure of the continuous model like nonnegativity, upper bounds, and entropy dis-sipation. The degeneracy is overcome by proving a new discrete Aubin-Lions lemma of "degenerate" type. Under suitable assumptions, the existence and uniqueness of bounded discrete solutions, a discrete entropy inequality, and the convergence of the scheme is proved. Numerical simulations of a calcium-selective ion channel in two space dimensions indicate that the numerical scheme is of first order.