Concept-Centric Visual Turing Tests for Method Validation
This addresses the need for thorough validation in clinical practice by providing a more interpretable evaluation method for medical imaging systems.
The paper tackles the problem of limited interpretability in medical imaging machine learning by introducing a framework that evaluates classification methods based on interpretable clinical concepts, using a probabilistic model and sequential querying to expose dataset and method biases and reduce the number of queries needed for confident evaluation.
Recent advances in machine learning for medical imaging have led to impressive increases in model complexity and overall capabilities. However, the ability to discern the precise information a machine learning method is using to make decisions has lagged behind and it is often unclear how these performances are in fact achieved. Conventional evaluation metrics that reduce method performance to a single number or a curve only provide limited insights. Yet, systems used in clinical practice demand thorough validation that such crude characterizations miss. To this end, we present a framework to evaluate classification methods based on a number of interpretable concepts that are crucial for a clinical task. Our approach is inspired by the Turing Test concept and how to devise a test that adaptively questions a method for its ability to interpret medical images. To do this, we make use of a Twenty Questions paradigm whereby we use a probabilistic model to characterize the method's capacity to grasp task-specific concepts, and we introduce a strategy to sequentially query the method according to its previous answers. The results show that the probabilistic model is able to expose both the dataset's and the method's biases, and can be used to reduced the number of queries needed for confident performance evaluation.