Deep Learning Based Detection and Localization of Intracranial Aneurysms in Computed Tomography Angiography
This work addresses the detection of intracranial aneurysms in medical imaging, which is crucial for diagnosis and treatment planning, but it is incremental as it builds on existing deep learning methods with a specific enhancement.
The researchers tackled the problem of detecting and localizing intracranial aneurysms in CT angiography by developing CADIA, a deep learning model with a region proposal network and false-positive reduction module, achieving sensitivities of 63.9% at 0.25 FPPV and 77.5% at 1 FPPV, and outperforming a comparable model in accuracy and specificity.
Purpose: To develop CADIA, a supervised deep learning model based on a region proposal network coupled with a false-positive reduction module for the detection and localization of intracranial aneurysms (IA) from computed tomography angiography (CTA), and to assess our model's performance to a similar detection network. Methods: In this retrospective study, we evaluated 1,216 patients from two separate institutions who underwent CT for the presence of saccular IA>=2.5 mm. A two-step model was implemented: a 3D region proposal network for initial aneurysm detection and 3D DenseNetsfor false-positive reduction and further determination of suspicious IA. Free-response receiver operative characteristics (FROC) curve and lesion-/patient-level performance at established false positive per volume (FPPV) were also performed. Fisher's exact test was used to compare with a similar available model. Results: CADIA's sensitivities at 0.25 and 1 FPPV were 63.9% and 77.5%, respectively. Our model's performance varied with size and location, and the best performance was achieved in IA between 5-10 mm and in those at anterior communicating artery, with sensitivities at 1 FPPV of 95.8% and 94%, respectively. Our model showed statistically higher patient-level accuracy, sensitivity, and specificity when compared to the available model at 0.25 FPPV and the best F-1 score (P<=0.001). At 1 FPPV threshold, our model showed better accuracy and specificity (P<=0.001) and equivalent sensitivity. Conclusions: CADIA outperformed a comparable network in the detection task of IA. The addition of a false-positive reduction module is a feasible step to improve the IA detection models.