Tackling the Problem of Large Deformations in Deep Learning Based Medical Image Registration Using Displacement Embeddings
This addresses a key bottleneck in deep learning-based medical image registration for applications like interpatient MRI or lung CT, offering a novel solution to improve accuracy over conventional methods.
The paper tackles the problem of large deformations in medical image registration, such as in lung CT scans, by proposing a displacement embedding method that achieves errors below 2 mm in a single forward pass.
Though, deep learning based medical image registration is currently starting to show promising advances, often, it still fells behind conventional frameworks in terms of registration accuracy. This is especially true for applications where large deformations exist, such as registration of interpatient abdominal MRI or inhale-to-exhale CT lung registration. Most current works use U-Net-like architectures to predict dense displacement fields from the input images in different supervised and unsupervised settings. We believe that the U-Net architecture itself to some level limits the ability to predict large deformations (even when using multilevel strategies) and therefore propose a novel approach, where the input images are mapped into a displacement space and final registrations are reconstructed from this embedding. Experiments on inhale-to-exhale CT lung registration demonstrate the ability of our architecture to predict large deformations in a single forward path through our network (leading to errors below 2 mm).