Improved Preterm Prediction Based on Optimized Synthetic Sampling of EHG Signal
This work addresses preterm labor prediction for healthcare applications, but it is incremental as it focuses on optimizing existing synthetic sampling methods.
The paper tackled the problem of bias in preterm labor prediction using electrohysterogram (EHG) signals by optimizing synthetic sampling to balance class representation, achieving substantial improvement in prediction precision as verified on a public database.
Preterm labor is the leading cause of neonatal morbidity and mortality and has attracted research efforts from many scientific areas. The inter-relationship between uterine contraction and the underlying electrical activities makes uterine electrohysterogram (EHG) a promising direction for preterm detection and prediction. Due the scarcity of EHG signals, especially those of preterm patients, synthetic algorithms are applied to create artificial samples of preterm type in order to remove prediction bias towards term, at the expense of a reduction of the feature effectiveness in machine-learning based automatic preterm detecting. To address such problem, we quantify the effect of synthetic samples (balance coefficient) on features' effectiveness, and form a general performance metric by utilizing multiple feature scores with relevant weights that describe their contributions to class separation. Combined with the activation/inactivation functions that characterizes the effect of the abundance of training samples in term and preterm prediction precision, we obtain an optimal sample balance coefficient that compromise the effect of synthetic samples in removing bias towards the majority and the side-effect of reducing features' importance. Substantial improvement in prediction precision has been achieved through a set of numerical tests on public available TPEHG database, and it verifies the effectiveness of the proposed method.