Utilising Graph Machine Learning within Drug Discovery and Development
This review paper is for researchers and practitioners in pharmaceutical and biotechnology industries interested in applying GML to drug discovery and development, providing an overview of current applications and future potential.
This paper reviews the application of Graph Machine Learning (GML) in drug discovery and development, covering target identification, small molecule and biologic design, and drug repurposing. It highlights that GML is an emerging field with milestones such as repurposed drugs entering in vivo studies.
Graph Machine Learning (GML) is receiving growing interest within the pharmaceutical and biotechnology industries for its ability to model biomolecular structures, the functional relationships between them, and integrate multi-omic datasets - amongst other data types. Herein, we present a multidisciplinary academic-industrial review of the topic within the context of drug discovery and development. After introducing key terms and modelling approaches, we move chronologically through the drug development pipeline to identify and summarise work incorporating: target identification, design of small molecules and biologics, and drug repurposing. Whilst the field is still emerging, key milestones including repurposed drugs entering in vivo studies, suggest graph machine learning will become a modelling framework of choice within biomedical machine learning.