Detecting Pulmonary Coccidioidomycosis (Valley fever) with Deep Convolutional Neural Networks
This proof-of-concept study addresses the need for rapid and accurate diagnosis of Valley fever in dogs and potentially humans, with incremental application of existing methods to a new medical imaging dataset.
The paper tackled automated detection of pulmonary Coccidioidomycosis (Valley fever) in radiographic images using deep convolutional neural networks, achieving an AUC above 0.99 with 10-fold cross-validation and enabling disease localization via visual heatmaps.
Coccidioidomycosis is the most common systemic mycosis in dogs in the southwestern United States. With warming climates, affected areas and number of cases are expected to increase in the coming years, escalating also the chances of transmission to humans. As a result, developing methods for automating the detection of the disease is important, as this will help doctors and veterinarians more easily identify and diagnose positive cases. We apply machine learning models to provide accurate and interpretable predictions of Coccidioidomycosis. We assemble a set of radiographic images and use it to train and test state-of-the-art convolutional neural networks to detect Coccidioidomycosis. These methods are relatively inexpensive to train and very fast at inference time. We demonstrate the successful application of this approach to detect the disease with an Area Under the Curve (AUC) above 0.99 using 10-fold cross validation. We also use the classification model to identify regions of interest and localize the disease in the radiographic images, as illustrated through visual heatmaps. This proof-of-concept study establishes the feasibility of very accurate and rapid automated detection of Valley Fever in radiographic images.