Characterization Multimodal Connectivity of Brain Network by Hypergraph GAN for Alzheimer's Disease Analysis
This work addresses a domain-specific challenge in neuroimaging for Alzheimer's disease research, offering an incremental improvement over existing multimodal fusion methods.
The paper tackled the problem of insufficiently leveraging complementary information from rs-fMRI and DTI in Alzheimer's disease analysis by proposing a Hypergraph GAN model, which improved classification performance and identified discriminative brain regions using ADNI data.
Using multimodal neuroimaging data to characterize brain network is currently an advanced technique for Alzheimer's disease(AD) Analysis. Over recent years the neuroimaging community has made tremendous progress in the study of resting-state functional magnetic resonance imaging (rs-fMRI) derived from blood-oxygen-level-dependent (BOLD) signals and Diffusion Tensor Imaging (DTI) derived from white matter fiber tractography. However, Due to the heterogeneity and complexity between BOLD signals and fiber tractography, Most existing multimodal data fusion algorithms can not sufficiently take advantage of the complementary information between rs-fMRI and DTI. To overcome this problem, a novel Hypergraph Generative Adversarial Networks(HGGAN) is proposed in this paper, which utilizes Interactive Hyperedge Neurons module (IHEN) and Optimal Hypergraph Homomorphism algorithm(OHGH) to generate multimodal connectivity of Brain Network from rs-fMRI combination with DTI. To evaluate the performance of this model, We use publicly available data from the ADNI database to demonstrate that the proposed model not only can identify discriminative brain regions of AD but also can effectively improve classification performance.