CyTran: A Cycle-Consistent Transformer with Multi-Level Consistency for Non-Contrast to Contrast CT Translation
This addresses the need for generating contrast CT scans for patients who cannot receive contrast substance and enhancing image alignment in medical imaging, though it is incremental as it builds on existing style transfer and cycle-consistency techniques.
The paper tackled the problem of translating between contrast and non-contrast CT scans using a cycle-consistent transformer model, achieving superior results compared to state-of-the-art methods and improving medical image alignment.
We propose a novel approach to translate unpaired contrast computed tomography (CT) scans to non-contrast CT scans and the other way around. Solving this task has two important applications: (i) to automatically generate contrast CT scans for patients for whom injecting contrast substance is not an option, and (ii) to enhance the alignment between contrast and non-contrast CT by reducing the differences induced by the contrast substance before registration. Our approach is based on cycle-consistent generative adversarial convolutional transformers, for short, CyTran. Our neural model can be trained on unpaired images, due to the integration of a multi-level cycle-consistency loss. Aside from the standard cycle-consistency loss applied at the image level, we propose to apply additional cycle-consistency losses between intermediate feature representations, which enforces the model to be cycle-consistent at multiple representations levels, leading to superior results. To deal with high-resolution images, we design a hybrid architecture based on convolutional and multi-head attention layers. In addition, we introduce a novel data set, Coltea-Lung-CT-100W, containing 100 3D triphasic lung CT scans (with a total of 37,290 images) collected from 100 female patients (there is one examination per patient). Each scan contains three phases (non-contrast, early portal venous, and late arterial), allowing us to perform experiments to compare our novel approach with state-of-the-art methods for image style transfer. Our empirical results show that CyTran outperforms all competing methods. Moreover, we show that CyTran can be employed as a preliminary step to improve a state-of-the-art medical image alignment method. We release our novel model and data set as open source at https://github.com/ristea/cycle-transformer.