A Two-Step Deep Learning Method for 3DCT-2DUS Kidney Registration During Breathing
It addresses difficulties in medical imaging registration for kidney procedures during breathing, which is an incremental improvement with specific domain application.
This work tackled the problem of registering 3D CT and 2D ultrasound kidney scans during free breathing by proposing a deep learning pipeline with a feature network and a 3D-2D CNN-based registration network, achieving a mean contour distance of 0.94 mm between kidneys on CT and ultrasound images.
This work proposed a novel deep registration pipeline for 3D CT and 2D U/S kidney scans of free breathing, which consists of a feature network, and a 3D-2D CNN-based registration network. The feature network has handcraft texture feature layers to reduce the semantic gap. The registration network is encoder-decoder structure with loss of feature-image-motion (FIM), which enables hierarchical regression at decoder layers and avoids multiple network concatenation. It was first pretrained with retrospective datasets cum training data generation strategy, then adapted to specific patient data under unsupervised one-cycle transfer learning in onsite application. The experiment was on 132 U/S sequences, 39 multiple phase CT and 210 public single phase CT images, and 25 pairs of CT and U/S sequences. It resulted in mean contour distance (MCD) of 0.94 mm between kidneys on CT and U/S images and MCD of 1.15 mm on CT and reference CT images. For datasets with small transformations, it resulted in MCD of 0.82 and 1.02 mm respectively. For large transformations, it resulted in MCD of 1.10 and 1.28 mm respectively. This work addressed difficulties in 3DCT-2DUS kidney registration during free breathing via novel network structures and training strategy.