Towards Saner Deep Image Registration
This work addresses model reliability issues in medical image registration, offering an incremental improvement by enforcing sanity checks on existing deep learning methods.
The paper tackled the problem of undesirable behaviors in deep image registration, such as low inverse consistency and poor discrimination of identical pairs, and proposed a regularization-based method that improved these sanity metrics without sacrificing performance.
With recent advances in computing hardware and surges of deep-learning architectures, learning-based deep image registration methods have surpassed their traditional counterparts, in terms of metric performance and inference time. However, these methods focus on improving performance measurements such as Dice, resulting in less attention given to model behaviors that are equally desirable for registrations, especially for medical imaging. This paper investigates these behaviors for popular learning-based deep registrations under a sanity-checking microscope. We find that most existing registrations suffer from low inverse consistency and nondiscrimination of identical pairs due to overly optimized image similarities. To rectify these behaviors, we propose a novel regularization-based sanity-enforcer method that imposes two sanity checks on the deep model to reduce its inverse consistency errors and increase its discriminative power simultaneously. Moreover, we derive a set of theoretical guarantees for our sanity-checked image registration method, with experimental results supporting our theoretical findings and their effectiveness in increasing the sanity of models without sacrificing any performance. Our code and models are available at https://github.com/tuffr5/Saner-deep-registration.