UniCell: Universal Cell Nucleus Classification via Prompt Learning
This work addresses the problem of inconsistent annotations in histopathological diagnosis for medical researchers and clinicians, representing an incremental improvement by leveraging shared knowledge across datasets.
The authors tackled inconsistent annotations across multiple pathological datasets for cell nucleus classification by proposing UniCell, a universal framework using prompt learning, which achieved state-of-the-art results on four benchmarks.
The recognition of multi-class cell nuclei can significantly facilitate the process of histopathological diagnosis. Numerous pathological datasets are currently available, but their annotations are inconsistent. Most existing methods require individual training on each dataset to deduce the relevant labels and lack the use of common knowledge across datasets, consequently restricting the quality of recognition. In this paper, we propose a universal cell nucleus classification framework (UniCell), which employs a novel prompt learning mechanism to uniformly predict the corresponding categories of pathological images from different dataset domains. In particular, our framework adopts an end-to-end architecture for nuclei detection and classification, and utilizes flexible prediction heads for adapting various datasets. Moreover, we develop a Dynamic Prompt Module (DPM) that exploits the properties of multiple datasets to enhance features. The DPM first integrates the embeddings of datasets and semantic categories, and then employs the integrated prompts to refine image representations, efficiently harvesting the shared knowledge among the related cell types and data sources. Experimental results demonstrate that the proposed method effectively achieves the state-of-the-art results on four nucleus detection and classification benchmarks. Code and models are available at https://github.com/lhaof/UniCell