A Domain Translation Framework with an Adversarial Denoising Diffusion Model to Generate Synthetic Datasets of Echocardiography Images
This provides a framework for creating clinically relevant synthetic echocardiography images to aid researchers and clinicians, though it is incremental as it builds on existing generative models.
The paper tackled the problem of generating synthetic echocardiography images for medical domain translation by proposing an adversarial Denoising Diffusion Model combined with a GAN, achieving high-quality results with MSE: 11.50 +/- 3.69, PSNR: 30.48 +/- 0.09 dB, and SSIM: 0.47 +/- 0.03.
Currently, medical image domain translation operations show a high demand from researchers and clinicians. Amongst other capabilities, this task allows the generation of new medical images with sufficiently high image quality, making them clinically relevant. Deep Learning (DL) architectures, most specifically deep generative models, are widely used to generate and translate images from one domain to another. The proposed framework relies on an adversarial Denoising Diffusion Model (DDM) to synthesize echocardiography images and perform domain translation. Contrary to Generative Adversarial Networks (GANs), DDMs are able to generate high quality image samples with a large diversity. If a DDM is combined with a GAN, this ability to generate new data is completed at an even faster sampling time. In this work we trained an adversarial DDM combined with a GAN to learn the reverse denoising process, relying on a guide image, making sure relevant anatomical structures of each echocardiography image were kept and represented on the generated image samples. For several domain translation operations, the results verified that such generative model was able to synthesize high quality image samples: MSE: 11.50 +/- 3.69, PSNR (dB): 30.48 +/- 0.09, SSIM: 0.47 +/- 0.03. The proposed method showed high generalization ability, introducing a framework to create echocardiography images suitable to be used for clinical research purposes.