Classification of colorectal primer carcinoma from normal colon with mid-infrared spectra
This work addresses a domain-specific medical diagnosis problem, but it appears incremental as it applies existing methods to new data without clear breakthroughs.
The study tackled the problem of classifying colorectal primer carcinoma from normal colon tissue using mid-infrared spectra, achieving classification by comparing multiple machine learning and deep learning models with data manipulation techniques and filtering, but did not report specific performance numbers.
In this project, we used formalin-fixed paraffin-embedded (FFPE) tissue samples to measure thousands of spectra per tissue core with Fourier transform mid-infrared spectroscopy using an FT-IR imaging system. These cores varied between normal colon (NC) and colorectal primer carcinoma (CRC) tissues. We created a database to manage all the multivariate data obtained from the measurements. Then, we applied classifier algorithms to identify the tissue based on its yielded spectra. For classification, we used the random forest, a support vector machine, XGBoost, and linear discriminant analysis methods, as well as three deep neural networks. We compared two data manipulation techniques using these models and then applied filtering. In the end, we compared model performances via the sum of ranking differences (SRD).