URCDM: Ultra-Resolution Image Synthesis in Histopathology
This addresses the need for realistic synthetic histopathology images for medical diagnosis, representing a strong specific gain in the domain.
The paper tackles the problem of synthesizing whole slide images in histopathology by proposing URCDMs, which generate ultra-resolution images capturing hierarchical details across magnification levels, achieving state-of-the-art results on three datasets and fooling expert evaluators.
Diagnosing medical conditions from histopathology data requires a thorough analysis across the various resolutions of Whole Slide Images (WSI). However, existing generative methods fail to consistently represent the hierarchical structure of WSIs due to a focus on high-fidelity patches. To tackle this, we propose Ultra-Resolution Cascaded Diffusion Models (URCDMs) which are capable of synthesising entire histopathology images at high resolutions whilst authentically capturing the details of both the underlying anatomy and pathology at all magnification levels. We evaluate our method on three separate datasets, consisting of brain, breast and kidney tissue, and surpass existing state-of-the-art multi-resolution models. Furthermore, an expert evaluation study was conducted, demonstrating that URCDMs consistently generate outputs across various resolutions that trained evaluators cannot distinguish from real images. All code and additional examples can be found on GitHub.